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SERPINI2 serpin family I member 2 [ Homo sapiens (human) ]

Gene ID: 5276, updated on 9-Jun-2025
Official Symbol
SERPINI2provided by HGNC
Official Full Name
serpin family I member 2provided by HGNC
Primary source
HGNC:HGNC:8945
See related
Ensembl:ENSG00000114204 MIM:605587; AllianceGenome:HGNC:8945
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEPI; PI14; PANCPIN; TSA2004
Summary
The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Expression
Restricted expression toward pancreas (RPKM 124.3) See more
Orthologs
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See SERPINI2 in Genome Data Viewer
Location:
3q26.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (167441933..167476963, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (170225816..170260848, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (167159721..167194751, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374196 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:166832178-166832678 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:166832679-166833179 Neighboring gene zinc finger B-box domain containing Neighboring gene long intergenic non-protein coding RNA 1327 Neighboring gene uncharacterized LOC105374197 Neighboring gene WD repeat domain 49 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_66573 Neighboring gene NANOG hESC enhancer GRCh37_chr3:167370944-167371467 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:167371468-167371990 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14866 Neighboring gene programmed cell death 10 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 8

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018
Products Interactant Other Gene Complex Source Pubs Description

Markers

Potential readthrough

Included gene: WDR49

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 
enables serine-type endopeptidase inhibitor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
serpin I2
Names
myoepithelium-derived serine protease inhibitor
myoepithelium-derived serine proteinase inhibitor
pancreas-specific protein TSA2004
peptidase inhibitor 14
protease inhibitor 14
serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2
serine (or cysteine) proteinase inhibitor, clade I (pancpin), member 2
serpin peptidase inhibitor, clade I (pancpin), member 2

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012303.3NP_001012303.2  serpin I2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC107311
    Consensus CDS
    CCDS3200.1
    UniProtKB/Swiss-Prot
    O75830
    UniProtKB/TrEMBL
    B4DDY9
    Related
    ENSP00000417692.1, ENST00000461846.5
    Conserved Domains (1) summary
    cd19576
    Location:23392
    serpinI2_pancpin; serpin family I member 2, pancpin
  2. NM_001394327.1NP_001381256.1  serpin I2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC107311
    Consensus CDS
    CCDS3200.1
    UniProtKB/Swiss-Prot
    O75830
    UniProtKB/TrEMBL
    B4DDY9
    Conserved Domains (1) summary
    cd19576
    Location:23392
    serpinI2_pancpin; serpin family I member 2, pancpin
  3. NM_006217.6NP_006208.1  serpin I2 precursor

    See identical proteins and their annotated locations for NP_006208.1

    Status: REVIEWED

    Source sequence(s)
    AC107311
    Consensus CDS
    CCDS3200.1
    UniProtKB/Swiss-Prot
    O75830
    UniProtKB/TrEMBL
    B4DDY9
    Related
    ENSP00000264677.4, ENST00000264677.9
    Conserved Domains (1) summary
    cd19576
    Location:23392
    serpinI2_pancpin; serpin family I member 2, pancpin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    167441933..167476963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    170225816..170260848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)