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SERPINI2 serpin family I member 2 [ Homo sapiens (human) ]

Gene ID: 5276, updated on 5-Jan-2022

Summary

Official Symbol
SERPINI2provided by HGNC
Official Full Name
serpin family I member 2provided by HGNC
Primary source
HGNC:HGNC:8945
See related
Ensembl:ENSG00000114204 MIM:605587
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MEPI; PI14; PANCPIN; TSA2004
Summary
The gene encodes a member of a family of proteins that acts as inhibitors of serine proteases. These proteins function in the regulation of a variety of physiological processes, including coagulation, fibrinolysis, development, malignancy, and inflammation. Expression of the encoded protein may be downregulated during pancreatic carcinogenesis. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]
Expression
Restricted expression toward pancreas (RPKM 124.3) See more
Orthologs
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Genomic context

See SERPINI2 in Genome Data Viewer
Location:
3q26.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (167441933..167476963, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (167159577..167191830, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374196 Neighboring gene zinc finger B-box domain containing Neighboring gene long intergenic non-protein coding RNA 1327 Neighboring gene uncharacterized LOC105374197 Neighboring gene WD repeat domain 49 Neighboring gene programmed cell death 10 Neighboring gene high mobility group nucleosome binding domain 1 pseudogene 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: WDR49

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular exosome HDA PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serpin I2
Names
myoepithelium-derived serine protease inhibitor
myoepithelium-derived serine proteinase inhibitor
pancreas-specific protein TSA2004
peptidase inhibitor 14
protease inhibitor 14
serine (or cysteine) proteinase inhibitor, clade I (neuroserpin), member 2
serine (or cysteine) proteinase inhibitor, clade I (pancpin), member 2
serpin peptidase inhibitor, clade I (pancpin), member 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012303.3NP_001012303.2  serpin I2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC107311
    Consensus CDS
    CCDS75047.1
    Related
    ENSP00000417692.1, ENST00000461846.5
    Conserved Domains (1) summary
    cd19576
    Location:23392
    serpinI2_pancpin; serpin family I member 2, pancpin
  2. NM_001394327.1NP_001381256.1  serpin I2 precursor

    Status: REVIEWED

    Source sequence(s)
    AC107311
    Conserved Domains (1) summary
    cd19576
    Location:23392
    serpinI2_pancpin; serpin family I member 2, pancpin
  3. NM_006217.6NP_006208.1  serpin I2 precursor

    See identical proteins and their annotated locations for NP_006208.1

    Status: REVIEWED

    Source sequence(s)
    AC107311
    Consensus CDS
    CCDS3200.1
    UniProtKB/Swiss-Prot
    O75830
    UniProtKB/TrEMBL
    B4DDY9
    Related
    ENSP00000264677.4, ENST00000264677.8
    Conserved Domains (1) summary
    cd19576
    Location:23392
    serpinI2_pancpin; serpin family I member 2, pancpin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    167441933..167476963 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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