Nudcd2 NudC domain containing 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Nudcd2provided by MGI
Official Full Name: NudC domain containing 2provided by MGI
Primary source: MGI:MGI:1277103
See related: Ensembl:ENSMUSG00000020328 AllianceGenome:MGI:1277103
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary: Predicted to enable unfolded protein binding activity. Predicted to be involved in protein folding. Predicted to be located in cytosol; intercellular bridge; and mitotic spindle. Predicted to be active in cytoplasm. Is expressed in embryo. Orthologous to human NUDCD2 (NudC domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E11.5 (RPKM 31.9), liver E14 (RPKM 19.0) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A5; 11 24.41 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (40624473..40630873)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (40733645..40740046)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

18.MMHAP76FRF9.seq (e-PCR)
- UniSTS:123397

RH138187 (e-PCR)
- UniSTS:220274

D11Ertd603e (e-PCR), detects polymorphism
- UniSTS:167065

Homology

Homologs of the Nudcd2 gene: The Nudcd2 gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 496 organisms have orthologs with human gene Nudcd2
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Process	Evidence Code	Pubs
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info	PubMed

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in chromosome, centromeric region	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nudC domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290697.1 → NP_001277626.1 nudC domain-containing protein 2 isoform 2

See identical proteins and their annotated locations for NP_001277626.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AK005909, AK010850, BE949482, CD776540, CJ083042

Consensus CDS

CCDS70162.1

UniProtKB/Swiss-Prot

Q9CQ48

UniProtKB/TrEMBL

A0A6P5QNW6, E0CYQ2

Related

ENSMUSP00000123991.2, ENSMUST00000127382.2

Conserved Domains (1) summary

cl00175
Location:12 → 80

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
NM_026023.5 → NP_080299.4 nudC domain-containing protein 2 isoform 1

See identical proteins and their annotated locations for NP_080299.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK005909, AK010850, CD776540, CJ083042

Consensus CDS

CCDS24549.1

UniProtKB/Swiss-Prot

Q9CQ48, Q9D0V4

UniProtKB/TrEMBL

A0A6P5QQE5, A0A8C6HLK6

Related

ENSMUSP00000020578.5, ENSMUST00000020578.11

Conserved Domains (1) summary

cd06494
Location:12 → 104

p23_NUDCD2_like; p23-like NUD (nuclear distribution) C-like found in human NUDC domain-containing protein 2 (NUDCD2) and similar proteins. Little is known about the function of the proteins in this subgroup.

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

40624473..40630873

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_030246122.2 → XP_030101982.1 nudC domain-containing protein 2 isoform X1

Conserved Domains (1) summary

cl00175
Location:7 → 48

alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.