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Cbx7 chromobox 7 [ Mus musculus (house mouse) ]

Gene ID: 52609, updated on 8-Dec-2022

Summary

Official Symbol
Cbx7provided by MGI
Official Full Name
chromobox 7provided by MGI
Primary source
MGI:MGI:1196439
See related
Ensembl:ENSMUSG00000053411 AllianceGenome:MGI:1196439
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D15Ertd417e; 1600014J01Rik
Summary
Enables chromatin binding activity; methylated histone binding activity; and single-stranded RNA binding activity. Acts upstream of or within sebaceous gland development. Located in heterochromatin and nucleus. Part of PRC1 complex. Is expressed in brain. Human ortholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX7 (chromobox 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in spleen adult (RPKM 23.7), placenta adult (RPKM 17.2) and 24 other tissues See more
Orthologs
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Genomic context

See Cbx7 in Genome Data Viewer
Location:
15 E1; 15 37.85 cM
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (79800005..79855344, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (79915804..79971143, complement)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene neuronal pentraxin chromo domain Neighboring gene chromobox 6 Neighboring gene RIKEN cDNA D730005E14 gene Neighboring gene apolipoprotein B mRNA editing enzyme, catalytic polypeptide 3 Neighboring gene VISTA enhancer mm570 Neighboring gene predicted gene, 53903 Neighboring gene microRNA 7213 Neighboring gene platelet derived growth factor, B polypeptide

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables single-stranded RNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of PRC1 complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of PcG protein complex ISO
Inferred from Sequence Orthology
more info
 
located_in chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in heterochromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
chromobox protein homolog 7
Names
chromobox homolog 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144811.3NP_659060.1  chromobox protein homolog 7

    See identical proteins and their annotated locations for NP_659060.1

    Status: VALIDATED

    Source sequence(s)
    AC113595, BC042657, BQ571764
    Consensus CDS
    CCDS37143.1
    UniProtKB/Swiss-Prot
    Q8VDS3
    Related
    ENSMUSP00000105245.3, ENSMUST00000109616.9
    Conserved Domains (1) summary
    pfam00385
    Location:1360
    Chromo; Chromo (CHRromatin Organization MOdifier) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    79800005..79855344 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011245690.3XP_011243992.1  chromobox protein homolog 7 isoform X2

    Conserved Domains (2) summary
    pfam17218
    Location:188219
    CBX7_C; CBX family C-terminal motif
    cl28914
    Location:1541
    CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
  2. XM_011245691.3XP_011243993.1  chromobox protein homolog 7 isoform X3

    See identical proteins and their annotated locations for XP_011243993.1

    Conserved Domains (1) summary
    pfam17218
    Location:155186
    CBX7_C; CBX family C-terminal motif
  3. XM_006521148.4XP_006521211.1  chromobox protein homolog 7 isoform X5

    Conserved Domains (1) summary
    pfam17218
    Location:96127
    CBX7_C; CBX family C-terminal motif
  4. XM_006521147.5XP_006521210.1  chromobox protein homolog 7 isoform X4

    Conserved Domains (2) summary
    cd18646
    Location:762
    CD_Cbx7; chromodomain of chromobox homolog 7
    pfam17218
    Location:150181
    CBX7_C; CBX family C-terminal motif
  5. XM_006521144.5XP_006521207.1  chromobox protein homolog 7 isoform X1

    UniProtKB/TrEMBL
    F8WHN2
    Related
    ENSMUSP00000086708.5, ENSMUST00000089293.11
    Conserved Domains (2) summary
    cd18646
    Location:762
    CD_Cbx7; chromodomain of chromobox homolog 7
    pfam17218
    Location:209240
    CBX7_C; CBX family C-terminal motif
  6. XM_011245692.4XP_011243994.1  chromobox protein homolog 7 isoform X3

    See identical proteins and their annotated locations for XP_011243994.1

    Conserved Domains (1) summary
    pfam17218
    Location:155186
    CBX7_C; CBX family C-terminal motif

RNA

  1. XR_003951404.2 RNA Sequence

  2. XR_384025.5 RNA Sequence