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Dhrs1 dehydrogenase/reductase 1 [ Mus musculus (house mouse) ]

Gene ID: 52585, updated on 2-Nov-2024

Summary

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Official Symbol
Dhrs1provided by MGI
Official Full Name
dehydrogenase/reductase 1provided by MGI
Primary source
MGI:MGI:1196314
See related
Ensembl:ENSMUSG00000002332 AllianceGenome:MGI:1196314
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D14Ertd484e; 1110029G07Rik
Summary
Predicted to enable carbonyl reductase (NADPH) activity. Located in mitochondrial inner membrane. Is expressed in dorsal root ganglion; glossopharyngeal ganglion; and trigeminal ganglion. Orthologous to human DHRS1 (dehydrogenase/reductase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 54.6), testis adult (RPKM 52.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Dhrs1 in Genome Data Viewer
Location:
14 C3; 14 28.19 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55976477..55983147, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55739020..55745684, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene transglutaminase 1, K polypeptide Neighboring gene STARR-seq mESC enhancer starr_36777 Neighboring gene Rab geranylgeranyl transferase, a subunit Neighboring gene STARR-positive B cell enhancer ABC_E7317 Neighboring gene STARR-positive B cell enhancer ABC_E2425 Neighboring gene NOP9 nucleolar protein Neighboring gene STARR-seq mESC enhancer starr_36778 Neighboring gene cell death-inducing DNA fragmentation factor, alpha subunit-like effector B Neighboring gene leukotriene B4 receptor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Proteomic analysis of the mouse liver mitochondrial inner membrane. Da Cruz S, et al. J Biol Chem, 2003 Oct 17. PMID 12865426
  2. Identification of new ciliary signaling pathways in the brain and insights into neurological disorders. Loukil A, et al. bioRxiv, 2023 Dec 21. PMID 38187761, Free PMC Article
  3. New roles for the de-ubiquitylating enzyme OTUD4 in an RNA-protein network and RNA granules. Das R, et al. J Cell Sci, 2019 Jun 17. PMID 31138677, Free PMC Article
  4. Network organization of the huntingtin proteomic interactome in mammalian brain. Shirasaki DI, et al. Neuron, 2012 Jul 12. PMID 22794259, Free PMC Article
  5. Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies. Murtaza N, et al. Cell Rep, 2022 Nov 22. PMID 36417873

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables carbonyl reductase (NADPH) activity ISO
Inferred from Sequence Orthology
more info
  
enables carbonyl reductase (NADPH) activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables estradiol 17-alpha-dehydrogenase [NAD(P)+] activity IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor ISS
Inferred from Sequence or Structural Similarity
more info
  
enables testosterone 17-beta-dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
dehydrogenase/reductase SDR family member 1
Names
dehydrogenase/reductase (SDR family) member 1
short chain dehydrogenase/reductase family 19C member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_026819.3 → NP_081095.2  dehydrogenase/reductase SDR family member 1

    See identical proteins and their annotated locations for NP_081095.2

    Status: VALIDATED

    Source sequence(s)
    AI845580, AK003958, AK159964, BU963142
    Consensus CDS
    CCDS36934.1
    UniProtKB/Swiss-Prot
    Q3THW0, Q99L04, Q9D148
    UniProtKB/TrEMBL
    Q3TVU9
    Related
    ENSMUSP00000002403.9, ENSMUST00000002403.10
    Conserved Domains (1) summary
    cd09763
    Location:5 → 271
    DHRS1-like_SDR_c; human dehydrogenase/reductase (SDR family) member 1 (DHRS1) -like, classical (c) SDRs

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55976477..55983147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158752.1 → XP_036014645.1  dehydrogenase/reductase SDR family member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3THW0, Q99L04, Q9D148
    UniProtKB/TrEMBL
    Q3TVU9
    Conserved Domains (1) summary
    cd09763
    Location:5 → 271
    DHRS1-like_SDR_c; human dehydrogenase/reductase (SDR family) member 1 (DHRS1) -like, classical (c) SDRs

  2. XM_030247886.1 → XP_030103746.1  dehydrogenase/reductase SDR family member 1 isoform X1

    UniProtKB/Swiss-Prot
    Q3THW0, Q99L04, Q9D148
    UniProtKB/TrEMBL
    Q3TVU9
    Conserved Domains (1) summary
    cd09763
    Location:5 → 271
    DHRS1-like_SDR_c; human dehydrogenase/reductase (SDR family) member 1 (DHRS1) -like, classical (c) SDRs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99L04.1 GenPept UniProtKB/Swiss-Prot:Q99L04

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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