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PFDN1 prefoldin subunit 1 [ Homo sapiens (human) ]

Gene ID: 5201, updated on 5-Aug-2018

Summary

Official Symbol
PFDN1provided by HGNC
Official Full Name
prefoldin subunit 1provided by HGNC
Primary source
HGNC:HGNC:8866
See related
Ensembl:ENSG00000113068 MIM:604897; Vega:OTTHUMG00000129249
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDF; PFD1
Summary
This gene encodes a member of the prefoldin beta subunit family. The encoded protein is one of six subunits of prefoldin, a molecular chaperone complex that binds and stabilizes newly synthesized polypeptides, thereby allowing them to fold correctly. The complex, consisting of two alpha and four beta subunits, forms a double beta barrel assembly with six protruding coiled-coils. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 19.4), fat (RPKM 19.3) and 25 other tissues See more
Orthologs

Genomic context

See PFDN1 in Genome Data Viewer
Location:
5q31.3
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (140245050..140303104, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (139624635..139682689, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101929719 Neighboring gene cysteine rich transmembrane module containing 1 Neighboring gene heparin binding EGF like growth factor Neighboring gene solute carrier family 4 member 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
protein binding involved in protein folding IPI
Inferred from Physical Interaction
more info
PubMed 
unfolded protein binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
protein folding IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
prefoldin complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
prefoldin subunit 1
Names
prefoldin 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002622.4NP_002613.2  prefoldin subunit 1

    See identical proteins and their annotated locations for NP_002613.2

    Status: REVIEWED

    Source sequence(s)
    AA910992, AC011380, BG707314
    Consensus CDS
    CCDS4222.1
    UniProtKB/Swiss-Prot
    O60925
    Related
    ENSP00000261813.4, OTTHUMP00000159560, ENST00000261813.8, OTTHUMT00000251354
    Conserved Domains (1) summary
    pfam01920
    Location:14117
    Prefoldin_2; Prefoldin subunit

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    140245050..140303104 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268465.4XP_005268522.1  prefoldin subunit 1 isoform X1

    Conserved Domains (1) summary
    pfam01920
    Location:14100
    Prefoldin_2; Prefoldin subunit
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