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ASIC5 acid sensing ion channel subunit family member 5 [ Homo sapiens (human) ]

Gene ID: 51802, updated on 25-Jan-2022

Summary

Official Symbol
ASIC5provided by HGNC
Official Full Name
acid sensing ion channel subunit family member 5provided by HGNC
Primary source
HGNC:HGNC:17537
See related
Ensembl:ENSG00000256394 MIM:616693; AllianceGenome:HGNC:17537
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
INAC; ACCN5; HINAC
Summary
This gene belongs to the amiloride-sensitive Na+ channel and degenerin (NaC/DEG) family, members of which have been identified in many animal species ranging from the nematode to human. The amiloride-sensitive Na(+) channel encoded by this gene is primarily expressed in the small intestine, however, its exact function is not known. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See ASIC5 in Genome Data Viewer
Location:
4q32.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (155829699..155867303, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (156750881..156787429, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene guanylate cyclase 1 soluble subunit alpha 1 Neighboring gene uncharacterized LOC107984032 Neighboring gene uncharacterized LOC105377506 Neighboring gene guanylate cyclase 1 soluble subunit beta 1 Neighboring gene uncharacterized LOC105377507 Neighboring gene tryptophan 2,3-dioxygenase Neighboring gene cathepsin O

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ligand-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables proton channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
acid-sensing ion channel 5
Names
acid sensing (proton gated) ion channel family member 5
acid sensing ion channel family member 5
amiloride-sensitive cation channel 5, intestinal
amiloride-sensitive sodium channel
human intestine Na(+) channel

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017419.3NP_059115.1  acid-sensing ion channel 5

    See identical proteins and their annotated locations for NP_059115.1

    Status: REVIEWED

    Source sequence(s)
    AC093830, AJ252011
    Consensus CDS
    CCDS3793.1
    UniProtKB/Swiss-Prot
    Q9NY37
    Related
    ENSP00000442477.2, ENST00000537611.3
    Conserved Domains (1) summary
    pfam00858
    Location:41466
    ASC; Amiloride-sensitive sodium channel

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    155829699..155867303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017008291.1XP_016863780.1  acid-sensing ion channel 5 isoform X1

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003315914.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1271..30900 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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