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Ramp1 receptor (calcitonin) activity modifying protein 1 [ Mus musculus (house mouse) ]

Gene ID: 51801, updated on 8-Feb-2024

Summary

Official Symbol
Ramp1provided by MGI
Official Full Name
receptor (calcitonin) activity modifying protein 1provided by MGI
Primary source
MGI:MGI:1858418
See related
Ensembl:ENSMUSG00000034353 AllianceGenome:MGI:1858418
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
9130218E19Rik
Summary
Enables coreceptor activity. Acts upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in extracellular space. Predicted to be part of CGRP receptor complex and amylin receptor complex 1. Predicted to be active in cell surface. Predicted to colocalize with plasma membrane. Is expressed in several structures, including adrenal gland; alimentary system; bone; brain; and reproductive system. Orthologous to human RAMP1 (receptor activity modifying protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 23.9), colon adult (RPKM 15.0) and 16 other tissues See more
Orthologs
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Genomic context

See Ramp1 in Genome Data Viewer
Location:
1 D; 1 46.08 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (91107544..91152918)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (91179822..91225196)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35443 Neighboring gene RNA binding motif protein 44 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93080001-93080198 Neighboring gene proteasome (prosome, macropain) 28 subunit, alpha pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:93089975-93090287 Neighboring gene STARR-positive B cell enhancer ABC_E9471 Neighboring gene STARR-positive B cell enhancer ABC_E498 Neighboring gene ubiquitin-conjugating enzyme E2F (putative) Neighboring gene zinc finger protein 330 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (7)  1 citation
  • Endonuclease-mediated (3) 

Pathways from PubChem

General gene information

Clone Names

  • MGC38240

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables amylin receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables calcitonin gene-related peptide binding ISO
Inferred from Sequence Orthology
more info
 
enables calcitonin gene-related peptide receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables coreceptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables coreceptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables coreceptor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IPI
Inferred from Physical Interaction
more info
PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in amylin receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in calcitonin gene-related peptide receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in calcium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in calcium ion transport ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to hormone stimulus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of protein glycosylation ISO
Inferred from Sequence Orthology
more info
 
involved_in protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in protein transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein transport ISO
Inferred from Sequence Orthology
more info
 
involved_in receptor internalization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in receptor internalization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of CGRP receptor complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in cell surface IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
receptor activity-modifying protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168392.1NP_001161864.1  receptor activity-modifying protein 1 isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and coding region compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AC102874, BY707433, CB522711
    Consensus CDS
    CCDS48321.1
    UniProtKB/TrEMBL
    A0A087WPC6
    Related
    ENSMUSP00000139720.2, ENSMUST00000188475.7
    Conserved Domains (1) summary
    pfam04901
    Location:3763
    RAMP; Receptor activity modifying family
  2. NM_016894.3NP_058590.1  receptor activity-modifying protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_058590.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC102874, AK165238, BY733497
    Consensus CDS
    CCDS15158.1
    UniProtKB/Swiss-Prot
    Q9WTJ5
    UniProtKB/TrEMBL
    Q3TNJ3
    Related
    ENSMUSP00000095253.5, ENSMUST00000097648.6
    Conserved Domains (1) summary
    pfam04901
    Location:38145
    RAMP; Receptor activity modifying family
  3. NM_178401.3NP_848488.2  receptor activity-modifying protein 1 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 3' exon, as compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, as compared to isoform 1.
    Source sequence(s)
    BY733497, CB522711
    Consensus CDS
    CCDS78648.1
    UniProtKB/TrEMBL
    E9Q915
    Related
    ENSMUSP00000128679.3, ENSMUST00000165855.8
    Conserved Domains (1) summary
    pfam04901
    Location:3763
    RAMP; Receptor activity modifying family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    91107544..91152918
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321671.1XP_017177160.1  receptor activity-modifying protein 1 isoform X1

    Conserved Domains (1) summary
    pfam04901
    Location:15123
    RAMP; Receptor activity modifying family