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Ech1 enoyl coenzyme A hydratase 1, peroxisomal [ Mus musculus (house mouse) ]

Gene ID: 51798, updated on 10-Feb-2024

Summary

Official Symbol
Ech1provided by MGI
Official Full Name
enoyl coenzyme A hydratase 1, peroxisomalprovided by MGI
Primary source
MGI:MGI:1858208
See related
Ensembl:ENSMUSG00000053898 AllianceGenome:MGI:1858208
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable delta3,5-delta2,4-dienoyl-CoA isomerase activity. Predicted to act upstream of or within fatty acid metabolic process. Located in mitochondrion. Is expressed in several structures, including adrenal gland; alimentary system; liver; and nervous system. Orthologous to human ECH1 (enoyl-CoA hydratase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in heart adult (RPKM 764.2), kidney adult (RPKM 330.1) and 19 other tissues See more
Orthologs
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Genomic context

See Ech1 in Genome Data Viewer
Location:
7 B1; 7 16.94 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (28524763..28531664)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (28825338..28832239)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene nuclear encoded tRNA lysine 24 (anticodon TTT) Neighboring gene Ras and Rab interactor-like Neighboring gene STARR-seq mESC enhancer starr_18438 Neighboring gene STARR-positive B cell enhancer ABC_E156 Neighboring gene STARR-positive B cell enhancer ABC_E8158 Neighboring gene heterogeneous nuclear ribonucleoprotein L Neighboring gene STARR-seq mESC enhancer starr_18440 Neighboring gene lectin, galactose binding, soluble 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:29650992-29651179 Neighboring gene lectin, galactose binding, soluble 7

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC107274

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables isomerase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
Names
dienoyl-CoA isomerase
peroxisomal/mitochondrial dienoyl-CoA isomerase
NP_058052.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016772.1NP_058052.1  delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial precursor

    See identical proteins and their annotated locations for NP_058052.1

    Status: PROVISIONAL

    Source sequence(s)
    AF030343
    Consensus CDS
    CCDS21057.1
    UniProtKB/Swiss-Prot
    O35459, Q5M8P6
    Related
    ENSMUSP00000066092.7, ENSMUST00000066264.13
    Conserved Domains (1) summary
    cl23717
    Location:53317
    crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    28524763..28531664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)