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Srpx sushi-repeat-containing protein [ Mus musculus (house mouse) ]

Gene ID: 51795, updated on 26-Sep-2022

Summary

Official Symbol
Srpxprovided by MGI
Official Full Name
sushi-repeat-containing proteinprovided by MGI
Primary source
MGI:MGI:1858306
See related
Ensembl:ENSMUSG00000090084 AllianceGenome:MGI:1858306
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
drs; DRS-1; DRS-2; drs-1; drs-2
Summary
Acts upstream of or within several processes, including negative regulation of cell proliferation involved in contact inhibition; phagolysosome assembly; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in autophagosome and endoplasmic reticulum. Is expressed in several structures, including otic capsule and skeleton. Orthologous to human SRPX (sushi repeat containing protein X-linked). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in mammary gland adult (RPKM 23.2), bladder adult (RPKM 15.6) and 16 other tissues See more
Orthologs
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Genomic context

See Srpx in Genome Data Viewer
Location:
X; X A1.1
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) X NC_000086.8 (9904216..9983879, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (10037977..10117640, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene synaptotagmin-like 5 Neighboring gene H2A histone family member L3 Neighboring gene predicted gene 5754 Neighboring gene predicted gene, 33844 Neighboring gene retinitis pigmentosa GTPase regulator

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (2) 

General gene information

Markers

Potential readthrough

Included gene: Rpgr

Homology

General protein information

Preferred Names
sushi-repeat-containing protein SRPX
Names
sushi-repeat-containing protein, X-chromosome

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365087.1NP_001352016.1  sushi-repeat-containing protein SRPX isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    BX005236
    Consensus CDS
    CCDS90696.1
    Related
    ENSMUSP00000111205.3, ENSMUST00000115543.3
    Conserved Domains (3) summary
    cd00033
    Location:178233
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam02494
    Location:91173
    HYR; HYR domain
    pfam13778
    Location:248367
    DUF4174; Domain of unknown function (DUF4174)
  2. NM_016911.5NP_058607.1  sushi-repeat-containing protein SRPX isoform 1 precursor

    See identical proteins and their annotated locations for NP_058607.1

    Status: VALIDATED

    Source sequence(s)
    BX005236
    Consensus CDS
    CCDS30013.1
    UniProtKB/Swiss-Prot
    Q9R0M2, Q9R0M3
    Related
    ENSMUSP00000047926.4, ENSMUST00000044789.10
    Conserved Domains (3) summary
    cd00033
    Location:262317
    CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
    pfam02494
    Location:175257
    HYR; HYR domain
    pfam13778
    Location:332449
    DUF4174; Domain of unknown function (DUF4174)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    9904216..9983879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)