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SYT17 synaptotagmin 17 [ Homo sapiens (human) ]

Gene ID: 51760, updated on 17-Nov-2020

Summary

Official Symbol
SYT17provided by HGNC
Official Full Name
synaptotagmin 17provided by HGNC
Primary source
HGNC:HGNC:24119
See related
Ensembl:ENSG00000103528
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Syt-17; sytXVII
Expression
Broad expression in brain (RPKM 8.9), prostate (RPKM 3.0) and 15 other tissues See more
Orthologs

Genomic context

See SYT17 in Genome Data Viewer
Location:
16p12.3
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (19167834..19268334)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (19179541..19279656)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene COQ7 divergent transcript Neighboring gene coenzyme Q7, hydroxylase Neighboring gene ITPRIP like 2 Neighboring gene uncharacterized LOC105371114 Neighboring gene C-type lectin domain containing 19A Neighboring gene long intergenic non-protein coding RNA 2858

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
syntaxin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
calcium-ion regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of dendrite extension IDA
Inferred from Direct Assay
more info
PubMed 
regulation of calcium ion-dependent exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of dopamine secretion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
presynapse IEA
Inferred from Electronic Annotation
more info
 
trans-Golgi network IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
synaptotagmin-17
Names
B/K protein
synaptotagmin XVII

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308157.2NP_001295086.1  synaptotagmin-17 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon which results in the use of an alternate start codon compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AA705977, AC003003, AC010494, AK098747
    Consensus CDS
    CCDS76835.1
    UniProtKB/TrEMBL
    H3BN78
    Related
    ENSP00000454721.2, ENST00000562711.6
    Conserved Domains (2) summary
    cd08390
    Location:182310
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08410
    Location:319453
    C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
  2. NM_001330509.2NP_001317438.1  synaptotagmin-17 isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate 5' terminal exon which results in the use of a downstream start codon compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA705977, AC003003, AC010494
    Consensus CDS
    CCDS81952.1
    UniProtKB/TrEMBL
    H3BRH9
    Conserved Domains (2) summary
    cd08390
    Location:125253
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08410
    Location:262396
    C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
  3. NM_016524.4NP_057608.2  synaptotagmin-17 isoform 1

    See identical proteins and their annotated locations for NP_057608.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AA705977, AC003003, AC010494, BC004518
    Consensus CDS
    CCDS10575.1
    UniProtKB/Swiss-Prot
    Q9BSW7
    Related
    ENSP00000347538.2, ENST00000355377.7
    Conserved Domains (2) summary
    cd08390
    Location:186314
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08410
    Location:323457
    C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    19167834..19268334
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450297.1XP_024306065.1  synaptotagmin-17 isoform X4

    Conserved Domains (2) summary
    cd08390
    Location:125253
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08410
    Location:262396
    C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
  2. XM_017023280.1XP_016878769.1  synaptotagmin-17 isoform X3

  3. XM_011545869.2XP_011544171.1  synaptotagmin-17 isoform X4

    See identical proteins and their annotated locations for XP_011544171.1

    UniProtKB/TrEMBL
    H3BRH9
    Conserved Domains (2) summary
    cd08390
    Location:125253
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08410
    Location:262396
    C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
  4. XM_011545871.2XP_011544173.1  synaptotagmin-17 isoform X4

    See identical proteins and their annotated locations for XP_011544173.1

    UniProtKB/TrEMBL
    H3BRH9
    Conserved Domains (2) summary
    cd08390
    Location:125253
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08410
    Location:262396
    C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
  5. XM_005255362.3XP_005255419.1  synaptotagmin-17 isoform X4

    See identical proteins and their annotated locations for XP_005255419.1

    UniProtKB/TrEMBL
    H3BRH9
    Conserved Domains (2) summary
    cd08390
    Location:125253
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08410
    Location:262396
    C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
  6. XM_011545872.2XP_011544174.1  synaptotagmin-17 isoform X4

    See identical proteins and their annotated locations for XP_011544174.1

    UniProtKB/TrEMBL
    H3BRH9
    Conserved Domains (2) summary
    cd08390
    Location:125253
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08410
    Location:262396
    C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
  7. XM_011545868.1XP_011544170.1  synaptotagmin-17 isoform X2

    Conserved Domains (2) summary
    cd08390
    Location:180308
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08410
    Location:317451
    C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
  8. XM_011545866.3XP_011544168.1  synaptotagmin-17 isoform X1

    Conserved Domains (2) summary
    cd08390
    Location:193321
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08410
    Location:330464
    C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
  9. XM_017023281.1XP_016878770.1  synaptotagmin-17 isoform X4

    UniProtKB/TrEMBL
    H3BRH9
    Related
    ENSP00000456252.1, ENST00000562034.5
    Conserved Domains (2) summary
    cd08390
    Location:125253
    C2A_Synaptotagmin-15-17; C2A domain first repeat present in Synaptotagmins 15 and 17
    cd08410
    Location:262396
    C2B_Synaptotagmin-17; C2 domain second repeat present in Synaptotagmin 17
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