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MSRB1 methionine sulfoxide reductase B1 [ Homo sapiens (human) ]

Gene ID: 51734, updated on 26-Apr-2020

Summary

Official Symbol
MSRB1provided by HGNC
Official Full Name
methionine sulfoxide reductase B1provided by HGNC
Primary source
HGNC:HGNC:14133
See related
Ensembl:ENSG00000198736 MIM:606216
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SELR; SELX; SepR; SEPX1; HSPC270
Summary
The protein encoded by this gene belongs to the methionine-R-sulfoxide reductase B (MsrB) family. Members of this family function as repair enzymes that protect proteins from oxidative stress by catalyzing the reduction of methionine-R-sulfoxides to methionines. This protein is highly expressed in liver and kidney, and is localized to the nucleus and cytosol. It is the only member of the MsrB family that is a selenoprotein, containing a selenocysteine (Sec) residue at its active site. It also has the highest methionine-R-sulfoxide reductase activity compared to other members containing cysteine in place of Sec. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. A pseudogene of this locus has been identified on chromosome 19. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in kidney (RPKM 37.2), liver (RPKM 35.6) and 25 other tissues See more
Orthologs

Genomic context

See MSRB1 in Genome Data Viewer
Location:
16p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (1938229..1943326, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1988234..1993294, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2124 Neighboring gene heparan sulfate-glucosamine 3-sulfotransferase 6 Neighboring gene ribosomal protein L3 like Neighboring gene NADH:ubiquinone oxidoreductase subunit B10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3344

Gene Ontology Provided by GOA

Function Evidence Code Pubs
L-methionine-(R)-S-oxide reductase activity IEA
Inferred from Electronic Annotation
more info
 
actin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
methionine-R-sulfoxide reductase activity IEA
Inferred from Electronic Annotation
more info
 
peptide-methionine (R)-S-oxide reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
actin filament polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
 
oxidation-reduction process IEA
Inferred from Electronic Annotation
more info
 
protein repair ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein repair TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
colocalizes_with actin cytoskeleton ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular_component ND
No biological Data available
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
methionine-R-sulfoxide reductase B1
Names
selenoprotein R
selenoprotein X, 1
NP_057416.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001382264.1NP_001369193.1  methionine-R-sulfoxide reductase B1 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC005363
  2. NM_001382265.1NP_001369194.1  methionine-R-sulfoxide reductase B1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC005363
  3. NM_016332.4NP_057416.1  methionine-R-sulfoxide reductase B1 isoform 1

    See identical proteins and their annotated locations for NP_057416.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC005363
    Consensus CDS
    CCDS42100.1
    UniProtKB/Swiss-Prot
    Q9NZV6
    Related
    ENSP00000355084.3, ENST00000361871.7
    Conserved Domains (1) summary
    cl15841
    Location:7116
    SelR; SelR domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    1938229..1943326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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