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LSM7 LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated [ Homo sapiens (human) ]

Gene ID: 51690, updated on 7-Jun-2020

Summary

Official Symbol
LSM7provided by HGNC
Official Full Name
LSM7 homolog, U6 small nuclear RNA and mRNA degradation associatedprovided by HGNC
Primary source
HGNC:HGNC:20470
See related
Ensembl:ENSG00000130332 MIM:607287
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
YNL147W
Summary
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of 2 regions separated by a linker of variable length that folds as a loop. The Sm-like proteins are thought to form a stable heteromer present in tri-snRNP particles, which are important for pre-mRNA splicing.[supplied by OMIM, Apr 2004]
Expression
Ubiquitous expression in colon (RPKM 29.6), bone marrow (RPKM 20.9) and 25 other tissues See more
Orthologs

Genomic context

See LSM7 in Genome Data Viewer
Location:
19p13.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (2321521..2328630, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (2321520..2328614, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene PEAK family member 3 Neighboring gene uncharacterized LOC101928572 Neighboring gene leucine rich repeat and Ig domain containing 3 Neighboring gene signal peptide peptidase like 2B Neighboring gene transmembrane serine protease 9 Neighboring gene origin of replication adjacent to lamin B2 Neighboring gene translocase of inner mitochondrial membrane 13 Neighboring gene lamin B2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
U6 snRNA binding NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
Lsm1-7-Pat1 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Lsm2-8 complex IDA
Inferred from Direct Assay
more info
PubMed 
U12-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U2-type precatalytic spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
U2-type prespliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
U4/U6 x U5 tri-snRNP complex IDA
Inferred from Direct Assay
more info
PubMed 
U6 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
ribonucleoprotein complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spliceosomal tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
U6 snRNA-associated Sm-like protein LSm7
Names
LSM7 U6 small nuclear RNA and mRNA degradation associated
LSM7 homolog, U6 small nuclear RNA associated

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016199.3NP_057283.1  U6 snRNA-associated Sm-like protein LSm7

    See identical proteins and their annotated locations for NP_057283.1

    Status: VALIDATED

    Source sequence(s)
    AF182293, BC018621, BI553911
    Consensus CDS
    CCDS45907.1
    UniProtKB/Swiss-Prot
    Q9UK45
    Related
    ENSP00000252622.8, ENST00000252622.15
    Conserved Domains (1) summary
    cd01729
    Location:997
    LSm7; Like-Sm protein 7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    2321521..2328630 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017026869.2XP_016882358.1  U6 snRNA-associated Sm-like protein LSm7 isoform X1

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