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TPPP3 tubulin polymerization promoting protein family member 3 [ Homo sapiens (human) ]

Gene ID: 51673, updated on 13-Jan-2020

Summary

Official Symbol
TPPP3provided by HGNC
Official Full Name
tubulin polymerization promoting protein family member 3provided by HGNC
Primary source
HGNC:HGNC:24162
See related
Ensembl:ENSG00000159713 MIM:616957
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p20; CGI-38; TPPP/p20; p25gamma
Expression
Broad expression in lung (RPKM 89.8), placenta (RPKM 51.0) and 18 other tissues See more
Orthologs

Genomic context

See TPPP3 in Genome Data Viewer
Location:
16q22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (67389807..67393498, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67423710..67427449, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 19 Neighboring gene RN7SK pseudogene 118 Neighboring gene leucine rich repeat containing 36 Neighboring gene RNA, U1 small nuclear 123, pseudogene Neighboring gene zinc finger DHHC-type containing 1 Neighboring gene hydroxysteroid 11-beta dehydrogenase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
tubulin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
microtubule bundle formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
microtubule bundle formation IDA
Inferred from Direct Assay
more info
PubMed 
microtubule polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein polymerization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
colocalizes_with microtubule bundle IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tubulin polymerization-promoting protein family member 3
Names
brain specific protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015964.4NP_057048.2  tubulin polymerization-promoting protein family member 3

    See identical proteins and their annotated locations for NP_057048.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC000691, BQ640401
    Consensus CDS
    CCDS10835.1
    UniProtKB/Swiss-Prot
    Q9BW30
    UniProtKB/TrEMBL
    A0A024R702
    Related
    ENSP00000377529.2, ENST00000393957.7
    Conserved Domains (1) summary
    pfam05517
    Location:11166
    p25-alpha; p25-alpha
  2. NM_016140.4NP_057224.2  tubulin polymerization-promoting protein family member 3

    See identical proteins and their annotated locations for NP_057224.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    BC000691, BI754230
    Consensus CDS
    CCDS10835.1
    UniProtKB/Swiss-Prot
    Q9BW30
    UniProtKB/TrEMBL
    A0A024R702
    Related
    ENSP00000290942.5, ENST00000290942.9
    Conserved Domains (1) summary
    pfam05517
    Location:11166
    p25-alpha; p25-alpha

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    67389807..67393498 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024450294.1XP_024306062.1  tubulin polymerization-promoting protein family member 3 isoform X1

    Related
    ENSP00000462435.1, ENST00000564104.5
    Conserved Domains (1) summary
    pfam05517
    Location:11166
    p25-alpha; p25-alpha
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