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MRPS23 mitochondrial ribosomal protein S23 [ Homo sapiens (human) ]

Gene ID: 51649, updated on 5-Sep-2021


Official Symbol
MRPS23provided by HGNC
Official Full Name
mitochondrial ribosomal protein S23provided by HGNC
Primary source
See related
Ensembl:ENSG00000181610 MIM:611985
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-138; COXPD46; HSPC329; MRP-S23
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. A pseudogene corresponding to this gene is found on chromosome 7p. [provided by RefSeq, Jul 2008]
Ubiquitous expression in heart (RPKM 19.2), prostate (RPKM 17.3) and 25 other tissues See more
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Genomic context

See MRPS23 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (57834781..57850044, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (55912142..55927405, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 182 Neighboring gene RN7SK pseudogene 94 Neighboring gene CUE domain containing 1 Neighboring gene uncharacterized LOC107985065 Neighboring gene uncharacterized LOC101929185 Neighboring gene vascular endothelial zinc finger 1

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
enables structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
Process Evidence Code Pubs
involved_in translation IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
located_in mitochondrion IDA
Inferred from Direct Assay
more info
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
located_in ribosome IEA
Inferred from Electronic Annotation
more info

General protein information

Preferred Names
28S ribosomal protein S23, mitochondrial
mitochondrial small ribosomal subunit protein mS23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016070.4NP_057154.2  28S ribosomal protein S23, mitochondrial

    See identical proteins and their annotated locations for NP_057154.2

    Status: REVIEWED

    Source sequence(s)
    AC015845, AF151896, AW299554, BC000242, BI962985, BX479815
    Consensus CDS
    ENSP00000320184.8, ENST00000313608.13
    Conserved Domains (1) summary
    MRP-S23; Mitochondrial ribosomal protein S23

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly


  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    57834781..57850044 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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