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PPIL1 peptidylprolyl isomerase like 1 [ Homo sapiens (human) ]

Gene ID: 51645, updated on 5-Dec-2021

Summary

Official Symbol
PPIL1provided by HGNC
Official Full Name
peptidylprolyl isomerase like 1provided by HGNC
Primary source
HGNC:HGNC:9260
See related
Ensembl:ENSG00000137168 MIM:601301
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CYPL1; PCH14; hCyPX; PPIase; CGI-124
Summary
This gene is a member of the cyclophilin family of peptidylprolyl isomerases (PPIases). The cyclophilins are a highly conserved, ubiquitous family, members of which play an important role in protein folding, immunosuppression by cyclosporin A, and infection of HIV-1 virions. Based on similarity to other PPIases, this protein could accelerate the folding of proteins and might catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 23.5), thyroid (RPKM 20.4) and 25 other tissues See more
Orthologs
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Genomic context

See PPIL1 in Genome Data Viewer
Location:
6p21.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (36854829..36874803, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (36822605..36842579, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor 166 pseudogene Neighboring gene copine 5 Neighboring gene chromosome 6 open reading frame 89 Neighboring gene peptidase inhibitor 16 Neighboring gene mitochondrial carrier 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
GeneReviews: Not available
Pontocerebellar hypoplasia, type 14
MedGen: CN301140 OMIM: 619301 GeneReviews: Not available
not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC678

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cyclosporin A binding IDA
Inferred from Direct Assay
more info
PubMed 
enables disordered domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peptidyl-prolyl cis-trans isomerase-like 1
Names
cyclophilin like 1
cyclophilin-related gene 1
peptidyl-prolyl cis-trans isomerase
peptidylprolyl isomerase (cyclophilin)-like 1
rotamase PPIL1
NP_057143.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016059.5NP_057143.1  peptidyl-prolyl cis-trans isomerase-like 1

    See identical proteins and their annotated locations for NP_057143.1

    Status: REVIEWED

    Source sequence(s)
    AK026636
    Consensus CDS
    CCDS4826.1
    UniProtKB/Swiss-Prot
    Q9Y3C6
    UniProtKB/TrEMBL
    A0A024RCX8
    Related
    ENSP00000362803.5, ENST00000373699.6
    Conserved Domains (1) summary
    cd01922
    Location:15161
    cyclophilin_SpCYP2_like; cyclophilin 2-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to Schizosaccharomyces pombe cyp-2. These proteins bind their respective SNW chromatin binding protein in autologous systems, in a CsA independent manner indicating ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    36854829..36874803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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