U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SF3B6 splicing factor 3b subunit 6 [ Homo sapiens (human) ]

Gene ID: 51639, updated on 6-Nov-2022

Summary

Official Symbol
SF3B6provided by HGNC
Official Full Name
splicing factor 3b subunit 6provided by HGNC
Primary source
HGNC:HGNC:30096
See related
Ensembl:ENSG00000115128 MIM:607835; AllianceGenome:HGNC:30096
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P14; Ht006; SAP14; SAP14a; SF3B14; CGI-110; HSPC175; SF3B14a
Summary
This gene encodes a 14 kDa protein subunit of the splicing factor 3b complex. Splicing factor 3b associates with both the U2 and U11/U12 small nuclear ribonucleoprotein complexes (U2 snRNP) of spliceosomes. This 14 kDa protein interacts directly with subunit 1 of the splicing factor 3b complex. This 14 kDa protein also interacts directly with the adenosine that carries out the first transesterification step of splicing at the pre-mRNA branch site. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 53.9), colon (RPKM 39.5) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See SF3B6 in Genome Data Viewer
Location:
2p23.3
Exon count:
4
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (24067586..24076326, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (24102271..24111005, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (24290456..24299196, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene WD repeat and coiled coil containing Neighboring gene FKBP prolyl isomerase 1B Neighboring gene RNA, U6 small nuclear 370, pseudogene Neighboring gene Sharpr-MPRA regulatory region 5215 Neighboring gene family with sequence similarity 228 member B Neighboring gene tumor protein p53 inducible protein 3 Neighboring gene profilin family member 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in U2-type prespliceosome assembly IC
Inferred by Curator
more info
PubMed 
involved_in blastocyst formation IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of U12-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U12-type spliceosomal complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of U2 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U2 snRNP IC
Inferred by Curator
more info
PubMed 
part_of U2-type spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U2-type spliceosomal complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IC
Inferred by Curator
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of spliceosomal complex IC
Inferred by Curator
more info
PubMed 

General protein information

Preferred Names
splicing factor 3B subunit 6
Names
SF3b 14 kDa subunit
pre-mRNA branch site protein p14
spliceosome-associated protein, 14 kDa subunit
spliceosome-associated protein, 14-kDa
splicing factor 3B, 14 kDa subunit
splicing factor 3b, subunit 6, 14kDa

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016047.4NP_057131.1  splicing factor 3B subunit 6

    See identical proteins and their annotated locations for NP_057131.1

    Status: REVIEWED

    Source sequence(s)
    BC015463, BG200650
    Consensus CDS
    CCDS1707.1
    UniProtKB/Swiss-Prot
    Q53TM1, Q9Y3B4
    Related
    ENSP00000233468.4, ENST00000233468.5
    Conserved Domains (1) summary
    cd12241
    Location:1793
    RRM_SF3B14; RNA recognition motif (RRM) found in pre-mRNA branch site protein p14 (SF3B14) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    24067586..24076326 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    24102271..24111005 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)