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NSG2 neuronal vesicle trafficking associated 2 [ Homo sapiens (human) ]

Gene ID: 51617, updated on 23-Nov-2023

Summary

Official Symbol
NSG2provided by HGNC
Official Full Name
neuronal vesicle trafficking associated 2provided by HGNC
Primary source
HGNC:HGNC:24955
See related
Ensembl:ENSG00000170091 MIM:616752; AllianceGenome:HGNC:24955
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CALY3; HMP19
Summary
Predicted to enable clathrin light chain binding activity. Predicted to be involved in clathrin coat assembly and endosomal transport. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 115.2) and adrenal (RPKM 19.2) See more
Orthologs
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Genomic context

See NSG2 in Genome Data Viewer
Location:
5q35.2
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (174045706..174109179)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (174586043..174649463)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (173472709..173536182)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:173446513-173447102 Neighboring gene chromosome 5 open reading frame 47 Neighboring gene ribosomal protein L12 pseudogene 22 Neighboring gene uncharacterized LOC102724551 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:173517875-173518376 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:173518377-173518876 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:173571770-173572270 Neighboring gene MPRA-validated peak5582 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:173586113-173586614 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:173630390-173630890 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:173632590-173633351 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:173631827-173632589 Neighboring gene uncharacterized LOC124901139 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23674 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:173734378-173734878 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16642 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:173754289-173754790 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:173754791-173755290 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:173755250-173756449 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:173762765-173763964 Neighboring gene long intergenic non-protein coding RNA 1411 Neighboring gene cysteine rich transmembrane module containing 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables clathrin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in dopamine receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
located_in Golgi cis cisterna membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasmic vesicle membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in late endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in lysosomal lumen IEA
Inferred from Electronic Annotation
more info
 
located_in multivesicular body membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in trans-Golgi network membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
neuronal vesicle trafficking-associated protein 2
Names
calcyon family member 3
hypothalamus golgi apparatus expressed 19 kDa protein
neuron-specific protein family member 2
p19 protein
protein p19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015980.5NP_057064.1  neuronal vesicle trafficking-associated protein 2

    See identical proteins and their annotated locations for NP_057064.1

    Status: VALIDATED

    Source sequence(s)
    BC002619, CD627354, DC366641, EL950772
    Consensus CDS
    CCDS4391.1
    UniProtKB/Swiss-Prot
    B2R5Y0, D3DQN0, Q9UHX8, Q9Y328
    UniProtKB/TrEMBL
    Q6IAL2
    Related
    ENSP00000307722.3, ENST00000303177.8
    Conserved Domains (1) summary
    pfam06387
    Location:1166
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    174045706..174109179
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    174586043..174649463
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)