Format

Send to:

Choose Destination

HPCAL4 hippocalcin like 4 [ Homo sapiens (human) ]

Gene ID: 51440, updated on 1-Jun-2020

Summary

Official Symbol
HPCAL4provided by HGNC
Official Full Name
hippocalcin like 4provided by HGNC
Primary source
HGNC:HGNC:18212
See related
Ensembl:ENSG00000116983
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HLP4
Summary
The protein encoded by this gene is highly similar to human hippocalcin protein and hippocalcin like-1 protein. It also has similarity to rat neural visinin-like Ca2+-binding protein-type 1 and 2 proteins. This encoded protein may be involved in the calcium-dependent regulation of rhodopsin phosphorylation. The transcript of this gene has multiple polyadenylation sites. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Expression
Biased expression in brain (RPKM 58.2), adrenal (RPKM 5.9) and 2 other tissues See more
Orthologs

Genomic context

See HPCAL4 in Genome Data Viewer
Location:
1p34.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (39678648..39691485, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40144320..40157382, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 4263 Neighboring gene 5'-nucleotidase, cytosolic IA Neighboring gene coiled-coil domain containing 25 pseudogene Neighboring gene RNA, U7 small nuclear 121 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp761G122

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium channel regulator activity IEA
Inferred from Electronic Annotation
more info
 
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
central nervous system development TAS
Traceable Author Statement
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
intracellular IDA
Inferred from Direct Assay
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001282396.1NP_001269325.1  hippocalcin-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_001269325.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AL035404, AL136591, BC030827, BM669991, DA107675, DA220121, HY156854
    Consensus CDS
    CCDS441.1
    UniProtKB/Swiss-Prot
    Q9UM19
    Related
    ENSP00000481834.1, ENST00000617690.2
    Conserved Domains (1) summary
    COG5126
    Location:13181
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  2. NM_001282397.1NP_001269326.1  hippocalcin-like protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001269326.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon, compared to variant 1. The resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AL035404, BM669991, DC333158, HY156854
    Consensus CDS
    CCDS72761.1
    UniProtKB/TrEMBL
    B4DGW9
    Related
    ENSP00000484070.1, ENST00000612703.3
    Conserved Domains (1) summary
    COG5126
    Location:13109
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
  3. NM_016257.4NP_057341.1  hippocalcin-like protein 4 isoform 1

    See identical proteins and their annotated locations for NP_057341.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same isoform (1).
    Source sequence(s)
    AL035404, BC030827, BM669991
    Consensus CDS
    CCDS441.1
    UniProtKB/Swiss-Prot
    Q9UM19
    Related
    ENSP00000361935.3, ENST00000372844.8
    Conserved Domains (1) summary
    COG5126
    Location:13181
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    39678648..39691485 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017001447.1XP_016856936.1  hippocalcin-like protein 4 isoform X1

    UniProtKB/Swiss-Prot
    Q9UM19
    Conserved Domains (1) summary
    COG5126
    Location:13181
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
Support Center