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ANAPC5 anaphase promoting complex subunit 5 [ Homo sapiens (human) ]

Gene ID: 51433, updated on 9-Feb-2020

Summary

Official Symbol
ANAPC5provided by HGNC
Official Full Name
anaphase promoting complex subunit 5provided by HGNC
Primary source
HGNC:HGNC:15713
See related
Ensembl:ENSG00000089053 MIM:606948
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
APC5
Summary
This gene encodes a tetratricopeptide repeat-containing component of the anaphase promoting complex/cyclosome (APC/C), a large E3 ubiquitin ligase that controls cell cycle progression by targeting a number of cell cycle regulators such as B-type cyclins for 26S proteasome-mediated degradation through ubiquitination. The encoded protein is required for the proper ubiquitination function of APC/C and for the interaction of APC/C with transcription coactivators. It also interacts with polyA binding protein and represses internal ribosome entry site-mediated translation. Multiple transcript variants encoding different isoforms have been found for this gene. These differences cause translation initiation at a downstream AUG and result in a shorter protein (isoform b), compared to isoform a. [provided by RefSeq, Nov 2008]
Expression
Ubiquitous expression in lymph node (RPKM 32.0), bone marrow (RPKM 28.9) and 25 other tissues See more
Orthologs

Genomic context

See ANAPC5 in Genome Data Viewer
Location:
12q24.31
Exon count:
18
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (121308245..121354209, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (121746048..121792012, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2X 4 Neighboring gene calcium/calmodulin dependent protein kinase kinase 2 Neighboring gene ring finger protein 34 Neighboring gene lysine demethylase 2B Neighboring gene microRNA 7107

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein phosphatase binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
cell cycle IEA
Inferred from Electronic Annotation
more info
 
cell division IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic metaphase/anaphase transition IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein K11-linked ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of mitotic cell cycle phase transition TAS
Traceable Author Statement
more info
 
ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
anaphase-promoting complex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
anaphase-promoting complex subunit 5
Names
cyclosome subunit 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001137559.1NP_001131031.1  anaphase-promoting complex subunit 5 isoform b

    See identical proteins and their annotated locations for NP_001131031.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and lacks an in-frame portion of the internal coding region, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in a shorter isoform (b) compared to isoform a.
    Source sequence(s)
    AA349724, AK025614, BX381618
    Consensus CDS
    CCDS45000.1
    UniProtKB/Swiss-Prot
    Q9UJX4
    Related
    ENSP00000415061.2, ENST00000441917.6
    Conserved Domains (3) summary
    sd00016
    Location:149183
    Apc5; TPR repeat [structural motif]
    cd16270
    Location:166
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
    pfam12862
    Location:155255
    ANAPC5; Anaphase-promoting complex subunit 5
  2. NM_001330489.2NP_001317418.1  anaphase-promoting complex subunit 5 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (c) is shorter but has the same N- and C-termini as isoform a.
    Source sequence(s)
    AA349724, AI879332, BC001950, BX381618, CR980654
    Consensus CDS
    CCDS81749.1
    UniProtKB/Swiss-Prot
    Q9UJX4
    UniProtKB/TrEMBL
    F5H0F9
    Related
    ENSP00000439875.1, ENST00000541887.5
    Conserved Domains (4) summary
    sd00016
    Location:248282
    Apc5; TPR repeat [structural motif]
    sd00006
    Location:454482
    TPR; TPR repeat [structural motif]
    cd16270
    Location:32165
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
    pfam12862
    Location:254354
    ANAPC5; Anaphase-promoting complex subunit 5
  3. NM_016237.5NP_057321.2  anaphase-promoting complex subunit 5 isoform a

    See identical proteins and their annotated locations for NP_057321.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA349724, AI879332, BC001950, BX381618
    Consensus CDS
    CCDS9220.1
    UniProtKB/Swiss-Prot
    Q9UJX4
    Related
    ENSP00000261819.3, ENST00000261819.8
    Conserved Domains (3) summary
    sd00016
    Location:248282
    Apc5; TPR repeat [structural motif]
    cd16270
    Location:32165
    Apc5_N; N-terminal domain of the anaphase-promoting complex subunit Apc5 (or Anapc5)
    pfam12862
    Location:254354
    ANAPC5; Anaphase-promoting complex subunit 5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    121308245..121354209 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019424.2XP_016874913.1  anaphase-promoting complex subunit 5 isoform X1

    UniProtKB/TrEMBL
    B4DFK4
  2. XM_017019423.2XP_016874912.1  anaphase-promoting complex subunit 5 isoform X1

    UniProtKB/TrEMBL
    B4DFK4
    Related
    ENSP00000438754.1, ENST00000535482.1
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