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ZMYND10 zinc finger MYND-type containing 10 [ Homo sapiens (human) ]

Gene ID: 51364, updated on 7-Dec-2018

Summary

Official Symbol
ZMYND10provided by HGNC
Official Full Name
zinc finger MYND-type containing 10provided by HGNC
Primary source
HGNC:HGNC:19412
See related
Ensembl:ENSG00000004838 MIM:607070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BLU; FLU; CILD22; DNAAF7
Summary
This gene encodes a protein containing a MYND-type zinc finger domain that likely functions in assembly of the dynein motor. Mutations in this gene can cause primary ciliary dyskinesia. This gene is also considered a tumor suppressor gene and is often mutated, deleted, or hypermethylated and silenced in cancer cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]
Expression
Restricted expression toward testis (RPKM 91.8) See more
Orthologs

Genomic context

See ZMYND10 in Genome Data Viewer
Location:
3p21.31
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (50341106..50345746, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50378537..50383459, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene tumor suppressor 2, mitochondrial calcium regulator Neighboring gene Ras association domain family member 1 Neighboring gene RASSF1 antisense RNA 1 Neighboring gene NPR2 like, GATOR1 complex subunit Neighboring gene cytochrome b561 family member D2 Neighboring gene transmembrane protein 115

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
inner dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
inner dynein arm assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
inner dynein arm assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
motile cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
motile cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
outer dynein arm assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
outer dynein arm assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
outer dynein arm assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of motile cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
apical plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
centriolar satellite ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger MYND domain-containing protein 10
Names
dynein axonemal assembly factor 7
protein BLu

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_042828.1 RefSeqGene

    Range
    5001..9641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001308379.1NP_001295308.1  zinc finger MYND domain-containing protein 10 isoform 2

    See identical proteins and their annotated locations for NP_001295308.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon and uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    BE500984, DB036846, U70880
    Consensus CDS
    CCDS77747.1
    UniProtKB/Swiss-Prot
    O75800
    Related
    ENSP00000353289.3, ENST00000360165.7
    Conserved Domains (1) summary
    pfam01753
    Location:389425
    zf-MYND; MYND finger
  2. NM_015896.4NP_056980.2  zinc finger MYND domain-containing protein 10 isoform 1

    See identical proteins and their annotated locations for NP_056980.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK315123, BC022186, DB036846
    Consensus CDS
    CCDS2825.1
    UniProtKB/Swiss-Prot
    O75800
    Related
    ENSP00000231749.3, ENST00000231749.7
    Conserved Domains (1) summary
    pfam01753
    Location:394430
    zf-MYND; MYND finger

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    50341106..50345746 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005265216.3XP_005265273.1  zinc finger MYND domain-containing protein 10 isoform X1

    Conserved Domains (1) summary
    pfam01753
    Location:315351
    zf-MYND; MYND finger
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