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SLC22A17 solute carrier family 22 member 17 [ Homo sapiens (human) ]

Gene ID: 51310, updated on 2-Nov-2024

Summary

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Official Symbol
SLC22A17provided by HGNC
Official Full Name
solute carrier family 22 member 17provided by HGNC
Primary source
HGNC:HGNC:23095
See related
Ensembl:ENSG00000092096 MIM:611461; AllianceGenome:HGNC:23095
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BOCT; BOIT; 24p3R; NGALR; hBOIT; NGALR2; NGALR3
Summary
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in siderophore transport. Located in organelle membrane and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in brain (RPKM 47.7), prostate (RPKM 11.1) and 10 other tissues See more
Orthologs
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Genomic context

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See SLC22A17 in Genome Data Viewer
Location:
14q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23346311..23352887, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17547327..17553903, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23815520..23822096, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene BCL2L2-PABPN1 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23776901-23777734 Neighboring gene BCL2 like 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:23789757-23790407 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:23790419-23791230 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:23791231-23792040 Neighboring gene poly(A) binding protein nuclear 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5608 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23832478-23832978 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23832979-23833479 Neighboring gene embryonal Fyn-associated substrate Neighboring gene interleukin 25

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The mRNA of solute carrier family 22, member 17 (SLC22A17) plays the potential diagnostic and prognostic role in advantage non-small cell lung cancer patients. Qin W, et al. Ann Biol Clin (Paris), 2024 Feb 24. PMID 38391165
  2. NGALR is overexpressed and regulated by hypomethylation in esophageal squamous cell carcinoma. Cui L, et al. Clin Cancer Res, 2008 Dec 1. PMID 19047093
  3. Lipocalin 2 decreases senescence of bone marrow-derived mesenchymal stem cells under sub-lethal doses of oxidative stress. Bahmani B, et al. Cell Stress Chaperones, 2014 Sep. PMID 24452457, Free PMC Article
  4. Increased expression of neutrophil gelatinase-associated lipocalin receptor by interleukin-1β in human mesangial cells via MAPK/ERK activation. Mao S, et al. Int J Mol Med, 2011 Apr. PMID 21305251
  5. Identification of immune cells and mRNA associated with prognosis of gastric cancer. Wang M, et al. BMC Cancer, 2020 Mar 12. PMID 32164594, Free PMC Article

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SLC22A17 as a Cell Death-Linked Regulator of Tight Junctions in Cerebral Ischemia.
    Title: SLC22A17 as a Cell Death-Linked Regulator of Tight Junctions in Cerebral Ischemia.
  2. The mRNA of solute carrier family 22, member 17 (SLC22A17) plays the potential diagnostic and prognostic role in advantage non-small cell lung cancer patients.
    Title: The mRNA of solute carrier family 22, member 17 (SLC22A17) plays the potential diagnostic and prognostic role in advantage non-small cell lung cancer patients.
  3. Identification of immune cells and mRNA associated with prognosis of gastric cancer.
    Title: Identification of immune cells and mRNA associated with prognosis of gastric cancer.
  4. Results showed the expression levels of NGAL and NGALR significantly downregulated in clear cell renal cell carcinoma samples.
    Title: The expression analysis of NGAL and NGALR in clear cell renal cell carcinoma.
  5. Biochemical and Structural Characterization of the Interaction between the Siderocalin NGAL/LCN2 (Neutrophil Gelatinase-associated Lipocalin/Lipocalin 2) and the N-terminal Domain of Its Endocytic Receptor SLC22A17.
    Title: Biochemical and Structural Characterization of the Interaction between the Siderocalin NGAL/LCN2 (Neutrophil Gelatinase-associated Lipocalin/Lipocalin 2) and the N-terminal Domain of Its Endocytic Receptor SLC22A17.
  6. Two novel variants in SLC22A17 and SLC22A7 were significantly associated with anthracycline-induced cardiotoxicity.
    Title: Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children.
  7. Lipocalin 2 might restore the health and regeneration potential of MSCs by decreasing senescence
    Title: Lipocalin 2 decreases senescence of bone marrow-derived mesenchymal stem cells under sub-lethal doses of oxidative stress.
  8. No significant difference was found in the expressions of NGALR mRNA in placenta among moderate preeclampsia group, severe preeclampsia group and control group.
    Title: [Correlation of lipocalin-2 and its receptor expressions with preeclampsia].
  9. NGAL and NGALR expression might be served as novel prognostic factors and potential therapeutic targets in Hepatocellular carcinoma.
    Title: NGAL and NGALR overexpression in human hepatocellular carcinoma toward a molecular prognostic classification.
  10. This study suggested that NGAL and NGALR expression are frequently up-regulated in gliomas, and are closely associated with poor clinical outcome.
    Title: NGAL and NGALR are frequently overexpressed in human gliomas and are associated with clinical prognosis.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transmembrane transporter activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in intracellular iron ion homeostasis TAS
Traceable Author Statement
more info
  
involved_in siderophore transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in organelle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 22 member 17
Names
24p3 receptor
NGAL receptor
brain-type organic cation transporter
lipocalin-2 receptor
neutrophil gelatinase-associated lipocalin receptor
potent brain type organic ion transporter
solute carrier family 22 (organic cation transporter), member 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289050.1 → NP_001275979.1  solute carrier family 22 member 17 isoform c

    See identical proteins and their annotated locations for NP_001275979.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of a coding exon and an alternate in-frame splice junction at the 3' end of another exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AK308661, BC020565, BF345519, DQ658848
    UniProtKB/Swiss-Prot
    Q8WUG5
    Conserved Domains (1) summary
    cl28910
    Location:88 → 258
    MFS; Major Facilitator Superfamily

  2. NM_016609.7 → NP_057693.4  solute carrier family 22 member 17 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL049829
    Consensus CDS
    CCDS9594.3
    Related
    ENSP00000346824.5, ENST00000354772.10
    Conserved Domains (1) summary
    cd17445
    Location:174 → 587
    MFS_SLC22A17; Solute carrier family 22, member 17 of the Major Facilitator Superfamily

  3. NM_020372.4 → NP_065105.3  solute carrier family 22 member 17 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL049829
    Consensus CDS
    CCDS9593.2
    UniProtKB/Swiss-Prot
    A0A1C7CYV9, A4UA13, A8MUT0, Q2TAB0, Q5BKY8, Q86U04, Q8WUG5, Q9H1D3, Q9NQD5
    Related
    ENSP00000380437.2, ENST00000397267.6
    Conserved Domains (1) summary
    cd17445
    Location:174 → 605
    MFS_SLC22A17; Solute carrier family 22, member 17 of the Major Facilitator Superfamily

RNA

  1. NR_110290.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate internal exons and uses two alternate splice junctions compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC030559, BI758221
    Related
    ENST00000474057.6

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    23346311..23352887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    17547327..17553903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WUG5.2 GenPept UniProtKB/Swiss-Prot:Q8WUG5

Gene LinkOut

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