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SLC22A17 solute carrier family 22 member 17 [ Homo sapiens (human) ]

Gene ID: 51310, updated on 26-Oct-2022

Summary

Official Symbol
SLC22A17provided by HGNC
Official Full Name
solute carrier family 22 member 17provided by HGNC
Primary source
HGNC:HGNC:23095
See related
Ensembl:ENSG00000092096 MIM:611461; AllianceGenome:HGNC:23095
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BOCT; BOIT; 24p3R; NGALR; hBOIT; NGALR2; NGALR3
Summary
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in siderophore transport. Is integral component of organelle membrane and integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 47.7), prostate (RPKM 11.1) and 10 other tissues See more
Orthologs
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Genomic context

See SLC22A17 in Genome Data Viewer
Location:
14q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23346311..23352887, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17547327..17553903, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23815520..23822096, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene BCL2L2-PABPN1 readthrough Neighboring gene BCL2 like 2 Neighboring gene poly(A) binding protein nuclear 1 Neighboring gene embryonal Fyn-associated substrate Neighboring gene interleukin 25

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transmembrane signaling receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transmembrane transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
involved_in cellular iron ion homeostasis TAS
Traceable Author Statement
more info
 
involved_in siderophore transport ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in organelle membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
solute carrier family 22 member 17
Names
24p3 receptor
NGAL receptor
brain-type organic cation transporter
lipocalin-2 receptor
neutrophil gelatinase-associated lipocalin receptor
potent brain type organic ion transporter
solute carrier family 22 (organic cation transporter), member 17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289050.1NP_001275979.1  solute carrier family 22 member 17 isoform c

    See identical proteins and their annotated locations for NP_001275979.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 5' end of a coding exon and an alternate in-frame splice junction at the 3' end of another exon compared to variant 1. The resulting isoform (c) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AK308661, BC020565, BF345519, DQ658848
    UniProtKB/Swiss-Prot
    Q8WUG5
    Conserved Domains (1) summary
    cl28910
    Location:88258
    MFS; Major Facilitator Superfamily
  2. NM_016609.7NP_057693.4  solute carrier family 22 member 17 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL049829
    Consensus CDS
    CCDS9594.3
    UniProtKB/TrEMBL
    A0A1C7CYV9
    Related
    ENSP00000346824.5, ENST00000354772.10
    Conserved Domains (1) summary
    cd17445
    Location:174587
    MFS_SLC22A17; Solute carrier family 22, member 17 of the Major Facilitator Superfamily
  3. NM_020372.4NP_065105.3  solute carrier family 22 member 17 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AL049829
    Consensus CDS
    CCDS9593.2
    Related
    ENSP00000380437.2, ENST00000397267.6
    Conserved Domains (1) summary
    cd17445
    Location:174605
    MFS_SLC22A17; Solute carrier family 22, member 17 of the Major Facilitator Superfamily

RNA

  1. NR_110290.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks two alternate internal exons and uses two alternate splice junctions compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC030559, BI758221
    Related
    ENST00000474057.6

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    23346311..23352887 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    17547327..17553903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)