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COA4 cytochrome c oxidase assembly factor 4 homolog [ Homo sapiens (human) ]

Gene ID: 51287, updated on 23-Nov-2021

Summary

Official Symbol
COA4provided by HGNC
Official Full Name
cytochrome c oxidase assembly factor 4 homologprovided by HGNC
Primary source
HGNC:HGNC:24604
See related
Ensembl:ENSG00000181924 MIM:608016
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CMC3; E2IG2; CHCHD8
Expression
Ubiquitous expression in adrenal (RPKM 9.0), thyroid (RPKM 7.6) and 25 other tissues See more
Orthologs
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Genomic context

See COA4 in Genome Data Viewer
Location:
11q13.4
Exon count:
4
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (73870258..73876901, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (73583712..73587891, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L48 Neighboring gene RN7SK pseudogene 243 Neighboring gene MIX23 pseudogene 5 Neighboring gene proteasomal ATPase associated factor 1 Neighboring gene actin related protein 2/3 complex subunit 3 pseudogene 4 Neighboring gene DnaJ heat shock protein family (Hsp40) member B13

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC117206, DKFZp762H1711

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in mitochondrial cytochrome c oxidase assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in mitochondrial intermembrane space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cytochrome c oxidase assembly factor 4 homolog, mitochondrial
Names
E2-induced gene 2 protein
coiled-coil-helix-coiled-coil-helix domain containing 8
coiled-coil-helix-coiled-coil-helix domain-containing protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016565.3NP_057649.2  cytochrome c oxidase assembly factor 4 homolog, mitochondrial

    See identical proteins and their annotated locations for NP_057649.2

    Status: VALIDATED

    Source sequence(s)
    AK000434, AP002770
    Consensus CDS
    CCDS8225.1
    UniProtKB/Swiss-Prot
    Q9NYJ1
    UniProtKB/TrEMBL
    A0A024R5J6
    Related
    ENSP00000347919.4, ENST00000355693.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    73870258..73876901 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017884.1XP_016873373.1  cytochrome c oxidase assembly factor 4 homolog, mitochondrial isoform X2

    UniProtKB/Swiss-Prot
    Q9NYJ1
    UniProtKB/TrEMBL
    A0A024R5J6
    Related
    ENSP00000437772.1, ENST00000537289.1
  2. XM_017017883.1XP_016873372.1  cytochrome c oxidase assembly factor 4 homolog, mitochondrial isoform X1

    UniProtKB/Swiss-Prot
    Q9NYJ1
    Related
    ENSP00000440756.1, ENST00000541455.1
    Conserved Domains (1) summary
    pfam06747
    Location:4376
    CHCH; CHCH domain
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