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MRPL51 mitochondrial ribosomal protein L51 [ Homo sapiens (human) ]

Gene ID: 51258, updated on 9-Feb-2020

Summary

Official Symbol
MRPL51provided by HGNC
Official Full Name
mitochondrial ribosomal protein L51provided by HGNC
Primary source
HGNC:HGNC:14044
See related
Ensembl:ENSG00000111639 MIM:611855
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDA09; MRP64; bMRP64; HSPC241
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Pseudogenes corresponding to this gene are found on chromosomes 4p and 21q. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 75.3), colon (RPKM 52.6) and 25 other tissues See more
Orthologs

Genomic context

See MRPL51 in Genome Data Viewer
Location:
12p13.31
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6491886..6493262, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6601316..6602471, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene TAP binding protein like Neighboring gene vesicle associated membrane protein 1 Neighboring gene plakophilin 2 pseudogene 1 Neighboring gene non-SMC condensin I complex subunit D2 Neighboring gene small Cajal body-specific RNA 10 Neighboring gene uncharacterized LOC112268089

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial large ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial ribosome IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L51, mitochondrial
Names
L51mt
MRP-L51
bMRP-64
mitochondrial large ribosomal subunit protein mL51
mitochondrial ribosomal protein 64
mitochondrial ribosomal protein bMRP64
NP_057581.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016497.4NP_057581.2  39S ribosomal protein L51, mitochondrial

    See identical proteins and their annotated locations for NP_057581.2

    Status: REVIEWED

    Source sequence(s)
    AC006064, AF212248, BC014329
    Consensus CDS
    CCDS8547.1
    UniProtKB/Swiss-Prot
    Q4U2R6
    Related
    ENSP00000229238.3, ENST00000229238.5
    Conserved Domains (1) summary
    pfam10244
    Location:38126
    MRP-L51; Mitochondrial ribosomal subunit

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    6491886..6493262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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