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MRPL37 mitochondrial ribosomal protein L37 [ Homo sapiens (human) ]

Gene ID: 51253, updated on 7-Apr-2024

Summary

Official Symbol
MRPL37provided by HGNC
Official Full Name
mitochondrial ribosomal protein L37provided by HGNC
Primary source
HGNC:HGNC:14034
See related
Ensembl:ENSG00000116221 MIM:611843; AllianceGenome:HGNC:14034
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L2mt; mL37; L37mt; MRPL2; RPML2; MRP-L2; MRP-L37
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 24.2), colon (RPKM 21.9) and 25 other tissues See more
Orthologs
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Genomic context

See MRPL37 in Genome Data Viewer
Location:
1p32.3
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (54200167..54225489)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (54083041..54108374)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (54665840..54691162)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54603591-54604217 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54630713-54631214 Neighboring gene CUB domain containing protein 2 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:54646436-54646936 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:54652758-54652971 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1056 Neighboring gene cytochrome b5 reductase like Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54689121-54689841 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54704367-54704867 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:54712147-54712309 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54714101-54714600 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54715268-54715931 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54716595-54717257 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54717258-54717919 Neighboring gene SSBP3 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54728759-54729751 Neighboring gene single stranded DNA binding protein 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54738457-54739025 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54740736-54741304 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54746851-54747658 Neighboring gene Sharpr-MPRA regulatory region 4453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54755897-54756569 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54763406-54763906 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54763907-54764407 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54777293-54777798 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54777799-54778302 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54794077-54794739 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54797494-54798031 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54802703-54803326 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54808704-54809225 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:54816098-54816645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54818040-54818718 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54820753-54821430 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1057 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1058 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54838933-54839482 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54841683-54842232 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1061 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1062 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54842784-54843333 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54843885-54844433 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54844434-54844984 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1063 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54857123-54857644 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54857645-54858164 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:54870662-54871573 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 917 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:54873396-54874305 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54876715-54877490 Neighboring gene VISTA enhancer hs1487 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:54929901-54930736 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1064 Neighboring gene Sharpr-MPRA regulatory region 12771 Neighboring gene Sharpr-MPRA regulatory region 12692 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54933797-54934298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54937369-54937869 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54940477-54941110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54941111-54941744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54941745-54942377 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54945522-54946108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54953393-54953911 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 918 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:54954958-54955168 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54965271-54965822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:54965823-54966374 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:54973259-54973431 Neighboring gene uncharacterized LOC105378735 Neighboring gene long intergenic non-protein coding RNA 2784

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
EBI GWAS Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
large ribosomal subunit protein mL37
Names
39S ribosomal protein L2, mitochondrial
39S ribosomal protein L37, mitochondrial
mitochondrial large ribosomal subunit protein mL37
ribosomal protein, mitochondrial, L2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330602.1NP_001317531.1  large ribosomal subunit protein mL37 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL161644, AL357673
    Consensus CDS
    CCDS81331.1
    UniProtKB/TrEMBL
    S4R369
    Related
    ENSP00000473980.1, ENST00000605337.5
    Conserved Domains (1) summary
    pfam07147
    Location:218385
    PDCD9; Mitochondrial 28S ribosomal protein S30 (PDCD9)
  2. NM_016491.4NP_057575.2  large ribosomal subunit protein mL37 isoform 2

    See identical proteins and their annotated locations for NP_057575.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AI245012, AK024572
    Consensus CDS
    CCDS589.1
    UniProtKB/Swiss-Prot
    Q96Q67, Q9BWR1, Q9BZE1, Q9P0P3
    Related
    ENSP00000354086.5, ENST00000360840.9
    Conserved Domains (1) summary
    pfam07147
    Location:271385
    PDCD9; Mitochondrial 28S ribosomal protein S30 (PDCD9)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    54200167..54225489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    54083041..54108374
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)