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MRPL37 mitochondrial ribosomal protein L37 [ Homo sapiens (human) ]

Gene ID: 51253, updated on 3-May-2020

Summary

Official Symbol
MRPL37provided by HGNC
Official Full Name
mitochondrial ribosomal protein L37provided by HGNC
Primary source
HGNC:HGNC:14034
See related
Ensembl:ENSG00000116221 MIM:611843
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L2mt; L37mt; MRPL2; RPML2; MRP-L2; MRP-L37
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in kidney (RPKM 24.2), colon (RPKM 21.9) and 25 other tissues See more
Orthologs

Genomic context

See MRPL37 in Genome Data Viewer
Location:
1p32.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (54200167..54225489)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (54665840..54691407)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene CUB domain containing protein 2 Neighboring gene cytochrome b5 reductase like Neighboring gene SSBP3 antisense RNA 1 Neighboring gene single stranded DNA binding protein 3 Neighboring gene VISTA enhancer hs1487

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study in the genetic analysis of idiopathic thrombophilia project suggests sex-specific regulation of mitochondrial DNA levels.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC878

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
structural constituent of ribosome NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
translation NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial ribosome NAS
Non-traceable Author Statement
more info
PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
39S ribosomal protein L37, mitochondrial
Names
39S ribosomal protein L2, mitochondrial
mitochondrial large ribosomal subunit protein mL37
ribosomal protein, mitochondrial, L2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330602.1NP_001317531.1  39S ribosomal protein L37, mitochondrial isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL161644, AL357673
    Consensus CDS
    CCDS81331.1
    UniProtKB/TrEMBL
    S4R369
    Related
    ENSP00000473980.1, ENST00000605337.5
    Conserved Domains (1) summary
    pfam07147
    Location:218385
    PDCD9; Mitochondrial 28S ribosomal protein S30 (PDCD9)
  2. NM_016491.4NP_057575.2  39S ribosomal protein L37, mitochondrial isoform 2

    See identical proteins and their annotated locations for NP_057575.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AI245012, AK024572
    Consensus CDS
    CCDS589.1
    UniProtKB/Swiss-Prot
    Q9BZE1
    Related
    ENSP00000354086.5, ENST00000360840.9
    Conserved Domains (1) summary
    pfam07147
    Location:271385
    PDCD9; Mitochondrial 28S ribosomal protein S30 (PDCD9)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    54200167..54225489
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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