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IGF2-AS IGF2 antisense RNA [ Homo sapiens (human) ]

Gene ID: 51214, updated on 24-May-2020

Summary

Official Symbol
IGF2-ASprovided by HGNC
Official Full Name
IGF2 antisense RNAprovided by HGNC
Primary source
HGNC:HGNC:14062
See related
Ensembl:ENSG00000099869 MIM:610146
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PEG8; IGF2AS; IGF2-AS1
Summary
This gene is expressed in antisense to the insulin-like growth factor 2 (IGF2) gene and is imprinted and paternally expressed. It is thought to be non-coding because the putative protein is not conserved and translation is predicted to trigger nonsense mediated decay (NMD). Transcripts from this gene are produced in tumors and may function to suppress cell growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
Expression
Biased expression in placenta (RPKM 5.4), liver (RPKM 4.4) and 3 other tissues See more
Orthologs

Genomic context

See IGF2-AS in Genome Data Viewer
Location:
11p15.5
Exon count:
3
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (2140512..2148666)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (2161758..2169896)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L23 Neighboring gene H19/IGF2 imprinting control region Neighboring gene H19 imprinted maternally expressed transcript Neighboring gene INS-IGF2 readthrough Neighboring gene microRNA 483 Neighboring gene insulin like growth factor 2 Neighboring gene insulin repeat instability region Neighboring gene insulin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene.
NHGRI GWA Catalog
Genome-wide association analysis of autoantibody positivity in type 1 diabetes cases.
NHGRI GWA Catalog
Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes.
NHGRI GWA Catalog

General gene information

Markers

Homology

Other Names

  • IGF2 antisense RNA 1 (non-protein coding)
  • PEG8/IGF2AS, imprinting
  • insulin-like growth factor 2 antisense 1 (non-protein coding)
  • insulin-like growth factor II, antisense

Clone Names

  • MGC168198

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_028043.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript.
    Source sequence(s)
    AC132217, AL530868, BC136585, BC142634
    Related
    ENST00000381361.4
  2. NR_133657.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate splice site resulting in a shorter transcript compared to variant 2.
    Source sequence(s)
    AC132217, AL530868, BC136585, BC142634
    Related
    ENST00000445504.3

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    2140512..2148666
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_016412.2: Suppressed sequence

    Description
    NM_016412.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
  2. NR_028044.1: Suppressed sequence

    Description
    NR_028044.1: This RefSeq was removed because currently there is insufficient support for the transcript.
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