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ZDHHC2 zinc finger DHHC-type containing 2 [ Homo sapiens (human) ]

Gene ID: 51201, updated on 17-Jun-2019

Summary

Official Symbol
ZDHHC2provided by HGNC
Official Full Name
zinc finger DHHC-type containing 2provided by HGNC
Primary source
HGNC:HGNC:18469
See related
Ensembl:ENSG00000104219
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DHHC2; ZNF372
Expression
Ubiquitous expression in thyroid (RPKM 18.6), adrenal (RPKM 10.6) and 24 other tissues See more
Orthologs

Genomic context

See ZDHHC2 in Genome Data Viewer
Location:
8p22
Exon count:
17
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (17156000..17230706)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (17013836..17080241)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene mitochondrial calcium uptake family member 3 Neighboring gene uncharacterized LOC107986918 Neighboring gene ribosomal protein L9 pseudogene 20 Neighboring gene CCR4-NOT transcription complex subunit 7 Neighboring gene VPS37A subunit of ESCRT-I Neighboring gene myotubularin related protein 7 Neighboring gene uncharacterized LOC102724838

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Metabolism of proteins, organism-specific biosystem (from REACTOME)
    Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
  • Surfactant metabolism, organism-specific biosystem (from REACTOME)
    Surfactant metabolism, organism-specific biosystemThe alveolar region of the lung creates an extensive epithelial surface that mediates the transfer of oxygen and carbon dioxide required for respiration after birth. Type I epithelial cells form the ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
palmitoyltransferase activity TAS
Traceable Author Statement
more info
 
protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein palmitoylation IDA
Inferred from Direct Assay
more info
PubMed 
protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
palmitoyltransferase ZDHHC2
Names
DHHC-2
ream
rec
reduced expression associated with metastasis protein
reduced expression in cancer protein
testis tissue sperm-binding protein Li 56e
zinc finger DHHC domain-containing protein 2
zinc finger protein 372
zinc finger, DHHC domain containing 2
NP_001349917.1
NP_001349918.1
NP_057437.1
XP_011542846.1
XP_011542847.1
XP_011542848.1
XP_011542850.1
XP_011542851.1
XP_024302945.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362988.1NP_001349917.1  palmitoyltransferase ZDHHC2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AB023584, AC079193, AC091050
    Conserved Domains (1) summary
    pfam01529
    Location:99220
    zf-DHHC; DHHC palmitoyltransferase
  2. NM_001362989.1NP_001349918.1  palmitoyltransferase ZDHHC2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AB023584, AC079193, AC091050
    Conserved Domains (1) summary
    pfam01529
    Location:82203
    zf-DHHC; DHHC palmitoyltransferase
  3. NM_016353.5NP_057437.1  palmitoyltransferase ZDHHC2 isoform 1

    See identical proteins and their annotated locations for NP_057437.1

    Status: VALIDATED

    Source sequence(s)
    AB023584, AC091050
    Consensus CDS
    CCDS47810.1
    UniProtKB/Swiss-Prot
    Q9UIJ5
    UniProtKB/TrEMBL
    A0A140VKD9
    Related
    ENSP00000262096.8, ENST00000262096.13
    Conserved Domains (1) summary
    cl19890
    Location:13302
    zf-DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    17156000..17230706
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544549.3XP_011542851.1  palmitoyltransferase ZDHHC2 isoform X7

    Conserved Domains (1) summary
    cl19890
    Location:150203
    zf-DHHC; DHHC palmitoyltransferase
  2. XM_011544544.3XP_011542846.1  palmitoyltransferase ZDHHC2 isoform X1

    Conserved Domains (1) summary
    pfam01529
    Location:172293
    zf-DHHC; DHHC palmitoyltransferase
  3. XM_011544545.3XP_011542847.1  palmitoyltransferase ZDHHC2 isoform X2

    Conserved Domains (1) summary
    pfam01529
    Location:143264
    zf-DHHC; DHHC palmitoyltransferase
  4. XM_011544546.3XP_011542848.1  palmitoyltransferase ZDHHC2 isoform X3

    Conserved Domains (1) summary
    pfam01529
    Location:128249
    zf-DHHC; DHHC palmitoyltransferase
  5. XM_024447177.1XP_024302945.1  palmitoyltransferase ZDHHC2 isoform X5

    Conserved Domains (1) summary
    pfam01529
    Location:82203
    zf-DHHC; DHHC palmitoyltransferase
  6. XM_011544548.3XP_011542850.1  palmitoyltransferase ZDHHC2 isoform X6

    See identical proteins and their annotated locations for XP_011542850.1

    Conserved Domains (1) summary
    pfam01529
    Location:71192
    zf-DHHC; DHHC palmitoyltransferase
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