ZDHHC2 zinc finger DHHC-type palmitoyltransferase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ZDHHC2provided by HGNC
Official Full Name: zinc finger DHHC-type palmitoyltransferase 2provided by HGNC
Primary source: HGNC:HGNC:18469
See related: Ensembl:ENSG00000104219 MIM:618621; AllianceGenome:HGNC:18469
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DHHC2; ZNF372
Summary: Enables protein homodimerization activity and protein-cysteine S-palmitoyltransferase activity. Involved in several processes, including peptidyl-L-cysteine S-palmitoylation; protein localization to membrane raft; and synapse assembly. Located in Golgi apparatus and endoplasmic reticulum membrane. Is active in postsynaptic recycling endosome. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in thyroid (RPKM 18.6), adrenal (RPKM 10.6) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p22

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (17156482..17224799)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (17424063..17492390)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (17013991..17082308)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis.
Title: Zdhhc2 Is Essential for Plasmacytoid Dendritic Cells Mediated Inflammatory Response in Psoriasis.
Fine-mapping of ZDHHC2 identifies risk variants for schizophrenia in the Han Chinese population.
Title: Fine-mapping of ZDHHC2 identifies risk variants for schizophrenia in the Han Chinese population.
These results suggest an important role for ZDHHC2 as a tumor suppressor in metastasis and recurrence of HCC.
Title: A critical role for ZDHHC2 in metastasis and recurrence in human hepatocellular carcinoma.
reduced ZDHHC2 expression is associated with lymph node metastasis and independently predicts an unfavorable prognosis in gastric adenocarcinoma patients
Title: Reduced expression of ZDHHC2 is associated with lymph node metastasis and poor prognosis in gastric adenocarcinoma.
DHHC2 localizes primarily to the endoplasmic reticulum and Golgi apparatus suggesting that it is involved in S-acylation of newly-synthesized or recycling Lck involved in T cell signalling.
Title: DHHC2 is a protein S-acyltransferase for Lck.
The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain
Title: The palmitoyl transferase DHHC2 targets a dynamic membrane cycling pathway: regulation by a C-terminal domain.
Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.
Title: Gi/o signaling and the palmitoyltransferase DHHC2 regulate palmitate cycling and shuttling of RGS7 family-binding protein.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
DHHC2-mediated palmitoylation of CKAP4 has a role in opposing cancer-related cellular behaviors.
Title: Palmitoylation of cytoskeleton associated protein 4 by DHHC2 regulates antiproliferative factor-mediated signaling.
DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151
Title: DHHC2 affects palmitoylation, stability, and functions of tetraspanins CD9 and CD151.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH103479 (e-PCR)
- UniSTS:97804

G32164 (e-PCR)
- UniSTS:16925

SHGC-170023 (e-PCR)
- UniSTS:173700

GDB:386001 (e-PCR)
- UniSTS:157140

RH36493 (e-PCR)
- UniSTS:4085

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables palmitoyltransferase activity	TAS Traceable Author Statement more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-cysteine S-myristoyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein-cysteine S-palmitoyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-cysteine S-palmitoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein-cysteine S-stearoyltransferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in peptidyl-L-cysteine S-palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in peptidyl-L-cysteine S-palmitoylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of AMPA glutamate receptor clustering	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of endosome to plasma membrane protein transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of long-term synaptic potentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to membrane raft	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein palmitoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein targeting to membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neuronal synaptic plasticity	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of postsynaptic neurotransmitter receptor diffusion trapping	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in synapse assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in synapse assembly	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi membrane	TAS Traceable Author Statement more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynaptic density	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic recycling endosome	IMP Inferred from Mutant Phenotype more info	PubMed
located_in postsynaptic recycling endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in postsynaptic recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: palmitoyltransferase ZDHHC2

Names: DHHC-2; acyltransferase ZDHHC2; ream; rec; reduced expression associated with metastasis protein; reduced expression in cancer protein; testis tissue sperm-binding protein Li 56e; zinc finger DHHC domain-containing protein 2; zinc finger DHHC-type containing 2; zinc finger protein 372; zinc finger, DHHC domain containing 2

NP_001349917.1

EC 2.3.1.225

NP_001349918.1

EC 2.3.1.225

NP_057437.1

EC 2.3.1.225

XP_011542846.1

EC 2.3.1.225

XP_011542847.1

EC 2.3.1.225

XP_011542848.1

EC 2.3.1.225

XP_011542850.1

EC 2.3.1.225

XP_011542851.1

EC 2.3.1.225

XP_024302945.1

EC 2.3.1.225

XP_054216590.1

EC 2.3.1.225

XP_054216591.1

EC 2.3.1.225

XP_054216592.1

EC 2.3.1.225

XP_054216593.1

EC 2.3.1.225

XP_054216594.1

EC 2.3.1.225

XP_054216595.1

EC 2.3.1.225

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001362988.2 → NP_001349917.1 palmitoyltransferase ZDHHC2 isoform 2

Status: VALIDATED

Source sequence(s)

AB023584, AC079193, AC091050

Conserved Domains (1) summary

pfam01529
Location:99 → 220

zf-DHHC; DHHC palmitoyltransferase
NM_001362989.2 → NP_001349918.1 palmitoyltransferase ZDHHC2 isoform 3

Status: VALIDATED

Source sequence(s)

AB023584, AC079193, AC091050

Conserved Domains (1) summary

pfam01529
Location:82 → 203

DHHC; DHHC palmitoyltransferase
NM_016353.5 → NP_057437.1 palmitoyltransferase ZDHHC2 isoform 1

See identical proteins and their annotated locations for NP_057437.1

Status: VALIDATED

Source sequence(s)

AB023584, AC091050

Consensus CDS

CCDS47810.1

UniProtKB/Swiss-Prot

D3DSP5, Q9UIJ5

UniProtKB/TrEMBL

A0A140VKD9

Related

ENSP00000262096.8, ENST00000262096.13

Conserved Domains (1) summary

cl19890
Location:13 → 302

DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

17156482..17224799

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011544544.4 → XP_011542846.1 palmitoyltransferase ZDHHC2 isoform X1

Conserved Domains (1) summary

pfam01529
Location:172 → 293

zf-DHHC; DHHC palmitoyltransferase
XM_011544545.4 → XP_011542847.1 palmitoyltransferase ZDHHC2 isoform X2

Conserved Domains (1) summary

pfam01529
Location:143 → 264

zf-DHHC; DHHC palmitoyltransferase
XM_011544549.4 → XP_011542851.1 palmitoyltransferase ZDHHC2 isoform X6

Conserved Domains (1) summary

cl19890
Location:150 → 203

zf-DHHC; DHHC palmitoyltransferase
XM_011544546.4 → XP_011542848.1 palmitoyltransferase ZDHHC2 isoform X3

Conserved Domains (1) summary

pfam01529
Location:128 → 249

zf-DHHC; DHHC palmitoyltransferase
XM_024447177.2 → XP_024302945.1 palmitoyltransferase ZDHHC2 isoform X4

Conserved Domains (1) summary

pfam01529
Location:82 → 203

DHHC; DHHC palmitoyltransferase
XM_011544548.4 → XP_011542850.1 palmitoyltransferase ZDHHC2 isoform X5

See identical proteins and their annotated locations for XP_011542850.1

Conserved Domains (1) summary

pfam01529
Location:71 → 192

zf-DHHC; DHHC palmitoyltransferase