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C3orf18 chromosome 3 open reading frame 18 [ Homo sapiens (human) ]

Gene ID: 51161, updated on 23-Nov-2021

Summary

Official Symbol
C3orf18provided by HGNC
Official Full Name
chromosome 3 open reading frame 18provided by HGNC
Primary source
HGNC:HGNC:24837
See related
Ensembl:ENSG00000088543
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
G20
Expression
Broad expression in heart (RPKM 6.2), testis (RPKM 4.7) and 24 other tissues See more
Orthologs
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Genomic context

See C3orf18 in Genome Data Viewer
Location:
3p21.31
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (50558025..50574835, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (50595456..50608458, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene calcium voltage-gated channel auxiliary subunit alpha2delta 2 Neighboring gene uncharacterized LOC105377082 Neighboring gene uncharacterized LOC105377083 Neighboring gene HemK methyltransferase family member 1 Neighboring gene VISTA enhancer hs1747 Neighboring gene cytokine inducible SH2 containing protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
uncharacterized protein C3orf18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171740.3NP_001165211.1  uncharacterized protein C3orf18 isoform 1

    See identical proteins and their annotated locations for NP_001165211.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AA716515, BC034766, DA535127, DB166816
    Consensus CDS
    CCDS2829.1
    UniProtKB/Swiss-Prot
    Q9UK00
    Related
    ENSP00000387606.1, ENST00000426034.5
    Conserved Domains (1) summary
    TIGR04216
    Location:1384
    halo_surf_glyco; major cell surface glycoprotein
  2. NM_001171741.3NP_001165212.1  uncharacterized protein C3orf18 isoform 1

    See identical proteins and their annotated locations for NP_001165212.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AA716515, AF188706, DA535127, DB027651
    Consensus CDS
    CCDS2829.1
    UniProtKB/Swiss-Prot
    Q9UK00
    Related
    ENSP00000404913.1, ENST00000449241.5
    Conserved Domains (1) summary
    TIGR04216
    Location:1384
    halo_surf_glyco; major cell surface glycoprotein
  3. NM_001171743.3NP_001165214.2  uncharacterized protein C3orf18 isoform 2

    See identical proteins and their annotated locations for NP_001165214.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. This results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AA716515, AK308074, AL833938, DA535127, DB166816
    Consensus CDS
    CCDS54589.1
    UniProtKB/Swiss-Prot
    Q9UK00
    Related
    ENSP00000414124.1, ENST00000441239.5
  4. NM_016210.5NP_057294.2  uncharacterized protein C3orf18 isoform 1

    See identical proteins and their annotated locations for NP_057294.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1). Variants 1, 2 and 3 encode the same isoform (1).
    Source sequence(s)
    AA716515, AL833938, DA535127
    Consensus CDS
    CCDS2829.1
    UniProtKB/Swiss-Prot
    Q9UK00
    Related
    ENSP00000349732.3, ENST00000357203.8
    Conserved Domains (1) summary
    TIGR04216
    Location:1384
    halo_surf_glyco; major cell surface glycoprotein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    50558025..50574835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533781.2XP_011532083.1  uncharacterized protein C3orf18 isoform X1

  2. XM_011533788.1XP_011532090.1  uncharacterized protein C3orf18 isoform X3

    See identical proteins and their annotated locations for XP_011532090.1

    UniProtKB/TrEMBL
    Q6ZP18
  3. XM_011533785.2XP_011532087.1  uncharacterized protein C3orf18 isoform X2

    See identical proteins and their annotated locations for XP_011532087.1

  4. XM_011533784.2XP_011532086.1  uncharacterized protein C3orf18 isoform X2

    See identical proteins and their annotated locations for XP_011532086.1

  5. XM_017006547.1XP_016862036.1  uncharacterized protein C3orf18 isoform X4

    UniProtKB/Swiss-Prot
    Q9UK00
  6. XM_011533790.1XP_011532092.1  uncharacterized protein C3orf18 isoform X4

    See identical proteins and their annotated locations for XP_011532092.1

    UniProtKB/Swiss-Prot
    Q9UK00
  7. XM_017006545.1XP_016862034.1  uncharacterized protein C3orf18 isoform X3

    UniProtKB/TrEMBL
    Q6ZP18
  8. XM_011533782.2XP_011532084.1  uncharacterized protein C3orf18 isoform X2

    See identical proteins and their annotated locations for XP_011532084.1

  9. XM_011533789.1XP_011532091.1  uncharacterized protein C3orf18 isoform X3

    See identical proteins and their annotated locations for XP_011532091.1

    UniProtKB/TrEMBL
    Q6ZP18
  10. XM_024453548.1XP_024309316.1  uncharacterized protein C3orf18 isoform X3

  11. XM_011533783.2XP_011532085.1  uncharacterized protein C3orf18 isoform X2

    See identical proteins and their annotated locations for XP_011532085.1

  12. XM_024453549.1XP_024309317.1  uncharacterized protein C3orf18 isoform X3

  13. XM_017006546.1XP_016862035.1  uncharacterized protein C3orf18 isoform X3

    UniProtKB/TrEMBL
    Q6ZP18
  14. XM_024453550.1XP_024309318.1  uncharacterized protein C3orf18 isoform X3

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