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SERPINA10 serpin family A member 10 [ Homo sapiens (human) ]

Gene ID: 51156, updated on 8-Jul-2019

Summary

Official Symbol
SERPINA10provided by HGNC
Official Full Name
serpin family A member 10provided by HGNC
Primary source
HGNC:HGNC:15996
See related
Ensembl:ENSG00000140093 MIM:605271
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PZI; ZPI
Summary
The protein encoded by this gene belongs to the serpin family. It is predominantly expressed in the liver and secreted in plasma. It inhibits the activity of coagulation factors Xa and XIa in the presence of protein Z, calcium and phospholipid. Mutations in this gene are associated with venous thrombosis. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, May 2010]
Expression
Restricted expression toward liver (RPKM 44.6) See more
Orthologs

Genomic context

See SERPINA10 in Genome Data Viewer
Location:
14q32.13
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (94280460..94293353, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (94749648..94759608, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370634 Neighboring gene protein phosphatase 4 regulatory subunit 4 Neighboring gene serpin family A member 6 Neighboring gene serpin family A member 2 (gene/pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heparin binding IEA
Inferred from Electronic Annotation
more info
 
serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
blood coagulation IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
negative regulation of endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
NOT regulation of acrosome reaction IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
protein Z-dependent protease inhibitor
Names
PZ-dependent protease inhibitor
serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
serpin A10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_021202.2 RefSeqGene

    Range
    4989..14947
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001100607.3NP_001094077.1  protein Z-dependent protease inhibitor precursor

    See identical proteins and their annotated locations for NP_001094077.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF181467, AL117259, BC022261
    Consensus CDS
    CCDS9923.1
    UniProtKB/Swiss-Prot
    Q9UK55
    UniProtKB/TrEMBL
    A0A024R6I6
    Related
    ENSP00000261994.4, ENST00000261994.9
    Conserved Domains (1) summary
    cd02055
    Location:74438
    PZI; Protein Z-dependent protease inhibitor (ZPI) is a member of the serpin superfamily of proteinase inhibitors (clade A10). ZPI inhibits coagulation factor Xa , dependent on protein Z (PZ), a vitamin K-dependent plasma protein. ZPI also inhibits factor XIa ...
  2. NM_016186.2NP_057270.1  protein Z-dependent protease inhibitor precursor

    See identical proteins and their annotated locations for NP_057270.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AF181467, AI174900
    Consensus CDS
    CCDS9923.1
    UniProtKB/Swiss-Prot
    Q9UK55
    UniProtKB/TrEMBL
    A0A024R6I6
    Related
    ENSP00000376809.1, ENST00000393096.5
    Conserved Domains (1) summary
    cd02055
    Location:74438
    PZI; Protein Z-dependent protease inhibitor (ZPI) is a member of the serpin superfamily of proteinase inhibitors (clade A10). ZPI inhibits coagulation factor Xa , dependent on protein Z (PZ), a vitamin K-dependent plasma protein. ZPI also inhibits factor XIa ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    94280460..94293353 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017021353.1XP_016876842.1  protein Z-dependent protease inhibitor isoform X1

    UniProtKB/TrEMBL
    G3V2W1
    Related
    ENSP00000450896.1, ENST00000554723.5
    Conserved Domains (1) summary
    cd02055
    Location:114478
    PZI; Protein Z-dependent protease inhibitor (ZPI) is a member of the serpin superfamily of proteinase inhibitors (clade A10). ZPI inhibits coagulation factor Xa , dependent on protein Z (PZ), a vitamin K-dependent plasma protein. ZPI also inhibits factor XIa ...
  2. XM_005267733.5XP_005267790.1  protein Z-dependent protease inhibitor isoform X2

    See identical proteins and their annotated locations for XP_005267790.1

    UniProtKB/Swiss-Prot
    Q9UK55
    UniProtKB/TrEMBL
    A0A024R6I6
    Related
    ENSP00000450971.1, ENST00000554173.1
    Conserved Domains (1) summary
    cd02055
    Location:74438
    PZI; Protein Z-dependent protease inhibitor (ZPI) is a member of the serpin superfamily of proteinase inhibitors (clade A10). ZPI inhibits coagulation factor Xa , dependent on protein Z (PZ), a vitamin K-dependent plasma protein. ZPI also inhibits factor XIa ...

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187601.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1395022..1407830 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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