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A4GNT alpha-1,4-N-acetylglucosaminyltransferase [ Homo sapiens (human) ]

Gene ID: 51146, updated on 17-Jun-2024

Summary

Official Symbol
A4GNTprovided by HGNC
Official Full Name
alpha-1,4-N-acetylglucosaminyltransferaseprovided by HGNC
Primary source
HGNC:HGNC:17968
See related
Ensembl:ENSG00000118017 MIM:616709; AllianceGenome:HGNC:17968
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
alpha4GnT
Summary
This gene encodes a protein from the glycosyltransferase 32 family. The enzyme catalyzes the transfer of N-acetylglucosamine (GlcNAc) to core 2 branched O-glycans. It forms a unique glycan, GlcNAcalpha1-->4Galbeta-->R and is largely associated with the Golgi apparatus membrane. [provided by RefSeq, Jul 2008]
Expression
Biased expression in stomach (RPKM 9.5), duodenum (RPKM 0.9) and 1 other tissue See more
Orthologs
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Genomic context

See A4GNT in Genome Data Viewer
Location:
3q22.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (138123713..138133302, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (140864300..140873888, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (137842555..137851232, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374128 Neighboring gene NANOG hESC enhancer GRCh37_chr3:137765865-137766518 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20600 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:137789569-137790070 Neighboring gene DAZ interacting zinc finger protein 1 like Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:137833761-137834262 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:137834263-137834762 Neighboring gene keratin 8 pseudogene 36 Neighboring gene OCT4 hESC enhancer GRCh37_chr3:137879291-137879792 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20601 Neighboring gene debranching RNA lariats 1 Neighboring gene armadillo repeat containing 8 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14764 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20602 Neighboring gene NME/NM23 family member 9

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
alpha-1,4-N-acetylglucosaminyltransferase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016161.3NP_057245.1  alpha-1,4-N-acetylglucosaminyltransferase

    See identical proteins and their annotated locations for NP_057245.1

    Status: REVIEWED

    Source sequence(s)
    AC023049
    Consensus CDS
    CCDS3097.1
    UniProtKB/Swiss-Prot
    Q0VDK1, Q0VDK2, Q9UNA3
    Related
    ENSP00000236709.3, ENST00000236709.4
    Conserved Domains (2) summary
    pfam04488
    Location:64182
    Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
    pfam04572
    Location:201321
    Gb3_synth; Alpha 1,4-glycosyltransferase conserved region

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    138123713..138133302 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006544.2XP_016862033.1  alpha-1,4-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q0VDK1, Q0VDK2, Q9UNA3
    Conserved Domains (2) summary
    pfam04488
    Location:64182
    Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
    pfam04572
    Location:201321
    Gb3_synth; Alpha 1,4-glycosyltransferase conserved region
  2. XM_017006543.3XP_016862032.1  alpha-1,4-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q0VDK1, Q0VDK2, Q9UNA3
    Conserved Domains (2) summary
    pfam04488
    Location:64182
    Gly_transf_sug; Glycosyltransferase sugar-binding region containing DXD motif
    pfam04572
    Location:201321
    Gb3_synth; Alpha 1,4-glycosyltransferase conserved region

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    140864300..140873888 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054346723.1XP_054202698.1  alpha-1,4-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q0VDK1, Q0VDK2, Q9UNA3
  2. XM_054346722.1XP_054202697.1  alpha-1,4-N-acetylglucosaminyltransferase isoform X1

    UniProtKB/Swiss-Prot
    Q0VDK1, Q0VDK2, Q9UNA3