Format

Send to:

Choose Destination

GAL galanin and GMAP prepropeptide [ Homo sapiens (human) ]

Gene ID: 51083, updated on 18-Aug-2020

Summary

Official Symbol
GALprovided by HGNC
Official Full Name
galanin and GMAP prepropeptideprovided by HGNC
Primary source
HGNC:HGNC:4114
See related
Ensembl:ENSG00000069482 MIM:137035
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ETL8; GALN; GLNN; GMAP; GAL-GMAP
Summary
This gene encodes a neuroendocrine peptide that is widely expressed in the central and peripheral nervous systems and also the gastrointestinal tract, pancreas, adrenal gland and urogenital tract. The encoded protein is a precursor that is proteolytically processed to generate two mature peptides: galanin and galanin message-associated peptide (GMAP). Galanin has diverse physiological functions including nociception, feeding and energy homeostasis, osmotic regulation and water balance. GMAP has been demonstrated to possess antifungal activity and hypothesized to be part of the innate immune system. [provided by RefSeq, Jul 2015]
Expression
Biased expression in appendix (RPKM 6.0), colon (RPKM 2.3) and 5 other tissues See more
Orthologs

Genomic context

See GAL in Genome Data Viewer
Location:
11q13.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (68684544..68691175)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (68451983..68458643)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene LDL receptor related protein 5 Neighboring gene protein phosphatase 6 regulatory subunit 3 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 2 Neighboring gene uncharacterized LOC107984343 Neighboring gene Sharpr-MPRA regulatory region 1260 Neighboring gene testis expressed metallothionein like protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC40167

Gene Ontology Provided by GOA

Function Evidence Code Pubs
galanin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
galanin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide hormone activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuropeptide hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
neuropeptide hormone activity NAS
Non-traceable Author Statement
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
type 1 galanin receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
type 2 galanin receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
type 3 galanin receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
feeding behavior IEA
Inferred from Electronic Annotation
more info
 
inflammatory response IEA
Inferred from Electronic Annotation
more info
 
insulin secretion NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of lymphocyte proliferation IEA
Inferred from Electronic Annotation
more info
 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
neuropeptide signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cortisol secretion IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of large conductance calcium-activated potassium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of timing of catagen IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase A signaling IDA
Inferred from Direct Assay
more info
PubMed 
regulation of glucocorticoid metabolic process IEA
Inferred from Electronic Annotation
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to estrogen IEA
Inferred from Electronic Annotation
more info
 
response to immobilization stress IEA
Inferred from Electronic Annotation
more info
 
response to insulin IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
neuronal cell body IDA
Inferred from Direct Assay
more info
PubMed 
secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
galanin peptides
Names
galanin prepropeptide
galanin-message-associated peptide
galanin-related peptide
galanin/GMAP prepropeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_052785.1 RefSeqGene

    Range
    5070..11701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_015973.5NP_057057.2  galanin peptides preproprotein

    See identical proteins and their annotated locations for NP_057057.2

    Status: REVIEWED

    Source sequence(s)
    BC030241, BM846531
    Consensus CDS
    CCDS8183.1
    UniProtKB/Swiss-Prot
    P22466
    Related
    ENSP00000265643.3, ENST00000265643.4
    Conserved Domains (1) summary
    smart00071
    Location:23123
    Galanin; Galanin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    68684544..68691175
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center