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MRPS7 mitochondrial ribosomal protein S7 [ Homo sapiens (human) ]

Gene ID: 51081, updated on 21-Dec-2019

Summary

Official Symbol
MRPS7provided by HGNC
Official Full Name
mitochondrial ribosomal protein S7provided by HGNC
Primary source
HGNC:HGNC:14499
See related
Ensembl:ENSG00000125445 MIM:611974
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
S7mt; MRP-S; RP-S7; RPMS7; MRP-S7; COXPD34; bMRP27a
Summary
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein. In the prokaryotic ribosome, the comparable protein is thought to play an essential role in organizing the 3' domain of the 16 S rRNA in the vicinity of the P- and A-sites. Pseudogenes corresponding to this gene are found on chromosomes 8p and 12p. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in heart (RPKM 37.2), kidney (RPKM 29.1) and 25 other tissues See more
Orthologs

Genomic context

See MRPS7 in Genome Data Viewer
Location:
17q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (75261879..75266376)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73257749..73262457)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene small ubiquitin like modifier 2 Neighboring gene nucleoporin 85 Neighboring gene golgi associated, gamma adaptin ear containing, ARF binding protein 3 Neighboring gene uncharacterized LOC100287042 Neighboring gene MIF4G domain containing Neighboring gene solute carrier family 25 member 19 Neighboring gene growth factor receptor bound protein 2 Neighboring gene ribosomal protein L36a pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
rRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
mitochondrial translation ISS
Inferred from Sequence or Structural Similarity
more info
 
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
ribosomal small subunit assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
translation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial small ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial small ribosomal subunit ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
28S ribosomal protein S7, mitochondrial
Names
30S ribosomal protein S7 homolog
bMRP-27a
mitochondrial small ribosomal subunit protein uS7m
NP_057055.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015971.4NP_057055.2  28S ribosomal protein S7, mitochondrial

    See identical proteins and their annotated locations for NP_057055.2

    Status: REVIEWED

    Source sequence(s)
    AC022211
    Consensus CDS
    CCDS11718.1
    UniProtKB/Swiss-Prot
    Q9Y2R9
    UniProtKB/TrEMBL
    A0A024R8L0
    Related
    ENSP00000245539.6, ENST00000245539.11
    Conserved Domains (1) summary
    cd14870
    Location:35240
    uS7_Mitochondria_Mammalian; Mammalian Mitochondrial homolog of Ribosomal Protein S7

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    75261879..75266376
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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