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ASCC1 activating signal cointegrator 1 complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 51008, updated on 2-Nov-2024

Summary

Official Symbol
ASCC1provided by HGNC
Official Full Name
activating signal cointegrator 1 complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:24268
See related
Ensembl:ENSG00000138303 MIM:614215; AllianceGenome:HGNC:24268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p50; CGI-18; SMABF2; ASC1p50
Summary
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in testis (RPKM 7.6), brain (RPKM 6.4) and 25 other tissues See more
Orthologs
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Genomic context

See ASCC1 in Genome Data Viewer
Location:
10q22.1
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (72096032..72217134, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (72966865..73088203, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (73855790..73976892, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902448 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73828839-73829346 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73829527-73830028 Neighboring gene SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73840535-73841319 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene ReSE screen-validated silencer GRCh37_chr10:73950125-73950295 Neighboring gene ribosomal protein L15 pseudogene 14 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:73973271-73973772 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:73973773-73974272 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73975455-73976450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73977030-73977571 Neighboring gene anaphase promoting complex subunit 16 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3529 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74007658-74008225 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74008226-74008794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74008795-74009361 Neighboring gene Sharpr-MPRA regulatory region 8691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3533 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74020023-74020666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3535 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:74030210-74030710 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:74030711-74031211 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74032179-74032702 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74032703-74033226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:74035325-74035848 Neighboring gene DDIT4 antisense RNA 1 Neighboring gene DNA damage inducible transcript 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in DNA alkylation repair NAS
Non-traceable Author Statement
more info
PubMed 
involved_in DNA duplex unwinding NAS
Non-traceable Author Statement
more info
PubMed 
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of DNA repair complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
activating signal cointegrator 1 complex subunit 1
Names
ASC-1 complex subunit P50
trip4 complex subunit p50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031890.1 RefSeqGene

    Range
    5859..126103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198798.2NP_001185727.1  activating signal cointegrator 1 complex subunit 1 isoform b

    See identical proteins and their annotated locations for NP_001185727.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks three exons in the coding region, which results in a translational frameshift, compared to variant 1. Variants 2 and 4 encode the same isoform (b) which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC022392, BC012291, DA951859
    Consensus CDS
    CCDS31219.1
    UniProtKB/TrEMBL
    A0A5F9ZHP1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133356
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  2. NM_001198799.3NP_001185728.1  activating signal cointegrator 1 complex subunit 1 isoform a

    See identical proteins and their annotated locations for NP_001185728.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC022392, AK094170, DA942671
    Consensus CDS
    CCDS55713.1
    UniProtKB/Swiss-Prot
    Q5SW06, Q5SW07, Q8N9N2, Q96EI8, Q9Y307
    UniProtKB/TrEMBL
    A0A5F9ZHP1
    Related
    ENSP00000339404.4, ENST00000342444.8
    Conserved Domains (3) summary
    PLN00108
    Location:157370
    PLN00108; unknown protein; Provisional
    cd02394
    Location:99148
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:161349
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  3. NM_001198800.3NP_001185729.1  activating signal cointegrator 1 complex subunit 1 isoform b

    See identical proteins and their annotated locations for NP_001185729.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three exons in the coding region, which results in a translational frameshift, compared to variant 1. Variants 2 and 4 encode the same isoform (b) which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC022392, AK023436
    Consensus CDS
    CCDS31219.1
    UniProtKB/TrEMBL
    A0A5F9ZHP1
    Related
    ENSP00000500935.1, ENST00000672957.1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133356
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  4. NM_001369085.1NP_001356014.1  activating signal cointegrator 1 complex subunit 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    B7Z518
    Conserved Domains (2) summary
    cd02394
    Location:84142
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:155354
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  5. NM_001369086.1NP_001356015.1  activating signal cointegrator 1 complex subunit 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    B7Z518
    Conserved Domains (2) summary
    cd02394
    Location:84142
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:155354
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  6. NM_001369087.1NP_001356016.1  activating signal cointegrator 1 complex subunit 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    A0A5F9ZHP1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133332
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  7. NM_001369088.1NP_001356017.1  activating signal cointegrator 1 complex subunit 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    A0A5F9ZHP1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133332
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  8. NM_001369089.1NP_001356018.1  activating signal cointegrator 1 complex subunit 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    A0A5F9ZHP1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133332
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  9. NM_001369090.1NP_001356019.1  activating signal cointegrator 1 complex subunit 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    H0YCB3
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133332
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  10. NM_001369091.1NP_001356020.1  activating signal cointegrator 1 complex subunit 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    H0YCB3
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133332
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  11. NM_001369092.1NP_001356021.1  activating signal cointegrator 1 complex subunit 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    H0YCB3
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133332
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  12. NM_001369093.1NP_001356022.1  activating signal cointegrator 1 complex subunit 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Consensus CDS
    CCDS31219.1
    UniProtKB/TrEMBL
    A0A5F9ZHP1
    Related
    ENSP00000500488.1, ENST00000672774.1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133356
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  13. NM_001369094.1NP_001356023.1  activating signal cointegrator 1 complex subunit 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Consensus CDS
    CCDS31219.1
    UniProtKB/TrEMBL
    A0A5F9ZHP1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133356
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  14. NM_001369095.1NP_001356024.1  activating signal cointegrator 1 complex subunit 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Consensus CDS
    CCDS31219.1
    UniProtKB/TrEMBL
    A0A5F9ZHP1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133356
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  15. NM_001369096.1NP_001356025.1  activating signal cointegrator 1 complex subunit 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    A0A5F9ZHP1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133313
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  16. NM_001369097.1NP_001356026.1  activating signal cointegrator 1 complex subunit 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    A0A5F9ZHP1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133313
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  17. NM_001369098.1NP_001356027.1  activating signal cointegrator 1 complex subunit 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    A0A5F9ZHP1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133313
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  18. NM_001369099.1NP_001356028.1  activating signal cointegrator 1 complex subunit 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    B7Z518
    Conserved Domains (2) summary
    cd02394
    Location:84142
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:155338
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  19. NM_001369100.1NP_001356029.1  activating signal cointegrator 1 complex subunit 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133292
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  20. NM_001369101.1NP_001356030.1  activating signal cointegrator 1 complex subunit 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    H0YCB3
    Conserved Domains (2) summary
    cd02394
    Location:2381
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:94293
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  21. NM_001369102.1NP_001356031.1  activating signal cointegrator 1 complex subunit 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    H0YCB3
    Related
    ENSP00000431299.1, ENST00000486689.6
    Conserved Domains (2) summary
    cd02394
    Location:2381
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:94293
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  22. NM_001369103.1NP_001356032.1  activating signal cointegrator 1 complex subunit 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133292
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  23. NM_001369104.1NP_001356033.1  activating signal cointegrator 1 complex subunit 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133292
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  24. NM_001369105.1NP_001356034.1  activating signal cointegrator 1 complex subunit 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    A0A5F9ZHP1
    Conserved Domains (2) summary
    cd02394
    Location:2381
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:94317
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  25. NM_001369106.1NP_001356035.1  activating signal cointegrator 1 complex subunit 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    A0A5F9ZHP1
    Conserved Domains (2) summary
    cd02394
    Location:2381
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:94317
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  26. NM_001369107.1NP_001356036.1  activating signal cointegrator 1 complex subunit 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    A0A5F9ZHP1
    Conserved Domains (2) summary
    cd02394
    Location:2381
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:94317
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  27. NM_001369108.1NP_001356037.1  activating signal cointegrator 1 complex subunit 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Consensus CDS
    CCDS91260.1
    UniProtKB/TrEMBL
    A0A5F9ZH79, A0A5F9ZHP1
    Related
    ENSP00000500074.1, ENST00000672940.1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133316
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  28. NM_001369109.1NP_001356038.1  activating signal cointegrator 1 complex subunit 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Consensus CDS
    CCDS91260.1
    UniProtKB/TrEMBL
    A0A5F9ZH79, A0A5F9ZHP1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133316
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  29. NM_001369110.1NP_001356039.1  activating signal cointegrator 1 complex subunit 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    A0A5F9ZI37
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133287
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  30. NM_001369111.1NP_001356040.1  activating signal cointegrator 1 complex subunit 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    UniProtKB/TrEMBL
    A0A5F9ZI37
    Related
    ENSP00000500906.1, ENST00000671788.1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133287
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  31. NM_001369112.1NP_001356041.1  activating signal cointegrator 1 complex subunit 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Consensus CDS
    CCDS91259.1
    UniProtKB/TrEMBL
    A0A5K1VW55
    Related
    ENSP00000320810.7, ENST00000317168.11
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    cl26521
    Location:133247
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

RNA

  1. NR_045564.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5'-most exon and lacks three internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC022392, AK298302, CD706699, DC361917

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    72096032..72217134 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425261.1XP_047281217.1  activating signal cointegrator 1 complex subunit 1 isoform X6

  2. XM_047425258.1XP_047281214.1  activating signal cointegrator 1 complex subunit 1 isoform X4

  3. XM_047425257.1XP_047281213.1  activating signal cointegrator 1 complex subunit 1 isoform X3

  4. XM_047425259.1XP_047281215.1  activating signal cointegrator 1 complex subunit 1 isoform X5

  5. XM_024448032.2XP_024303800.1  activating signal cointegrator 1 complex subunit 1 isoform X1

    UniProtKB/TrEMBL
    B7Z518
    Conserved Domains (2) summary
    cd02394
    Location:84142
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:155335
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  6. XM_047425256.1XP_047281212.1  activating signal cointegrator 1 complex subunit 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    72966865..73088203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054365974.1XP_054221949.1  activating signal cointegrator 1 complex subunit 1 isoform X6

  2. XM_054365972.1XP_054221947.1  activating signal cointegrator 1 complex subunit 1 isoform X4

  3. XM_054365971.1XP_054221946.1  activating signal cointegrator 1 complex subunit 1 isoform X3

  4. XM_054365973.1XP_054221948.1  activating signal cointegrator 1 complex subunit 1 isoform X5

  5. XM_054365969.1XP_054221944.1  activating signal cointegrator 1 complex subunit 1 isoform X1

  6. XM_054365970.1XP_054221945.1  activating signal cointegrator 1 complex subunit 1 isoform X2

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_015947.3: Suppressed sequence

    Description
    NM_015947.3: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.