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ASCC1 activating signal cointegrator 1 complex subunit 1 [ Homo sapiens (human) ]

Gene ID: 51008, updated on 3-May-2020

Summary

Official Symbol
ASCC1provided by HGNC
Official Full Name
activating signal cointegrator 1 complex subunit 1provided by HGNC
Primary source
HGNC:HGNC:24268
See related
Ensembl:ENSG00000138303 MIM:614215
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p50; CGI-18; SMABF2; ASC1p50
Summary
This gene encodes a subunit of the activating signal cointegrator 1 (ASC-1) complex. The ASC-1 complex is a transcriptional coactivator that plays an important role in gene transactivation by multiple transcription factors including activating protein 1 (AP-1), nuclear factor kappa-B (NF-kB) and serum response factor (SRF). The encoded protein contains an N-terminal KH-type RNA-binding motif which is required for AP-1 transactivation by the ASC-1 complex. Mutations in this gene are associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
Expression
Ubiquitous expression in testis (RPKM 7.6), brain (RPKM 6.4) and 25 other tissues See more
Orthologs

Genomic context

See ASCC1 in Genome Data Viewer
Location:
10q22.1
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (72096032..72218777, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (73855790..73976892, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene carbohydrate sulfotransferase 3 Neighboring gene SPARC (osteonectin), cwcv and kazal like domains proteoglycan 2 Neighboring gene ribosomal protein L15 pseudogene 14 Neighboring gene anaphase promoting complex subunit 16 Neighboring gene DNA damage inducible transcript 4 Neighboring gene Sharpr-MPRA regulatory region 14427

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA dealkylation involved in DNA repair TAS
Traceable Author Statement
more info
 
regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
neuromuscular junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
nuclear speck IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
activating signal cointegrator 1 complex subunit 1
Names
ASC-1 complex subunit P50
trip4 complex subunit p50

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_031890.1 RefSeqGene

    Range
    5859..126103
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001198798.2NP_001185727.1  activating signal cointegrator 1 complex subunit 1 isoform b

    See identical proteins and their annotated locations for NP_001185727.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks three exons in the coding region, which results in a translational frameshift, compared to variant 1. Variants 2 and 4 encode the same isoform (b) which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC022392, BC012291, DA951859
    Consensus CDS
    CCDS31219.1
    UniProtKB/Swiss-Prot
    Q8N9N2
    UniProtKB/TrEMBL
    A0A024QZM0
    Related
    ENSP00000378377.1, ENST00000394919.5
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133356
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  2. NM_001198799.3NP_001185728.1  activating signal cointegrator 1 complex subunit 1 isoform a

    See identical proteins and their annotated locations for NP_001185728.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC022392, AK094170, DA942671
    Consensus CDS
    CCDS55713.1
    UniProtKB/Swiss-Prot
    Q8N9N2
    Related
    ENSP00000339404.4, ENST00000342444.8
    Conserved Domains (3) summary
    PLN00108
    Location:157370
    PLN00108; unknown protein; Provisional
    cd02394
    Location:99148
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:161349
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  3. NM_001198800.3NP_001185729.1  activating signal cointegrator 1 complex subunit 1 isoform b

    See identical proteins and their annotated locations for NP_001185729.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three exons in the coding region, which results in a translational frameshift, compared to variant 1. Variants 2 and 4 encode the same isoform (b) which is shorter and has a distinct C-terminus, compared to isoform a.
    Source sequence(s)
    AC022392, AK023436
    Consensus CDS
    CCDS31219.1
    UniProtKB/Swiss-Prot
    Q8N9N2
    UniProtKB/TrEMBL
    A0A024QZM0
    Related
    ENSP00000500935.1, ENST00000672957.1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133356
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  4. NM_001369085.1NP_001356014.1  activating signal cointegrator 1 complex subunit 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:84142
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:155354
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  5. NM_001369086.1NP_001356015.1  activating signal cointegrator 1 complex subunit 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:84142
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:155354
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  6. NM_001369087.1NP_001356016.1  activating signal cointegrator 1 complex subunit 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133332
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  7. NM_001369088.1NP_001356017.1  activating signal cointegrator 1 complex subunit 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133332
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  8. NM_001369089.1NP_001356018.1  activating signal cointegrator 1 complex subunit 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133332
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  9. NM_001369090.1NP_001356019.1  activating signal cointegrator 1 complex subunit 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133332
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  10. NM_001369091.1NP_001356020.1  activating signal cointegrator 1 complex subunit 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133332
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  11. NM_001369092.1NP_001356021.1  activating signal cointegrator 1 complex subunit 1 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133332
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  12. NM_001369093.1NP_001356022.1  activating signal cointegrator 1 complex subunit 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Related
    ENSP00000500488.1, ENST00000672774.1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133356
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  13. NM_001369094.1NP_001356023.1  activating signal cointegrator 1 complex subunit 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133356
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  14. NM_001369095.1NP_001356024.1  activating signal cointegrator 1 complex subunit 1 isoform b

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133356
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  15. NM_001369096.1NP_001356025.1  activating signal cointegrator 1 complex subunit 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133313
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  16. NM_001369097.1NP_001356026.1  activating signal cointegrator 1 complex subunit 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133313
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  17. NM_001369098.1NP_001356027.1  activating signal cointegrator 1 complex subunit 1 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133313
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  18. NM_001369099.1NP_001356028.1  activating signal cointegrator 1 complex subunit 1 isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:84142
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:155338
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  19. NM_001369100.1NP_001356029.1  activating signal cointegrator 1 complex subunit 1 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133292
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  20. NM_001369101.1NP_001356030.1  activating signal cointegrator 1 complex subunit 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:2381
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:94293
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  21. NM_001369102.1NP_001356031.1  activating signal cointegrator 1 complex subunit 1 isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Related
    ENSP00000431299.1, ENST00000486689.6
    Conserved Domains (2) summary
    cd02394
    Location:2381
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:94293
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  22. NM_001369103.1NP_001356032.1  activating signal cointegrator 1 complex subunit 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133292
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  23. NM_001369104.1NP_001356033.1  activating signal cointegrator 1 complex subunit 1 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133292
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  24. NM_001369105.1NP_001356034.1  activating signal cointegrator 1 complex subunit 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:2381
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:94317
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  25. NM_001369106.1NP_001356035.1  activating signal cointegrator 1 complex subunit 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:2381
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:94317
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  26. NM_001369107.1NP_001356036.1  activating signal cointegrator 1 complex subunit 1 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:2381
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:94317
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  27. NM_001369108.1NP_001356037.1  activating signal cointegrator 1 complex subunit 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Related
    ENSP00000500074.1, ENST00000672940.1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133316
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  28. NM_001369109.1NP_001356038.1  activating signal cointegrator 1 complex subunit 1 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133316
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  29. NM_001369110.1NP_001356039.1  activating signal cointegrator 1 complex subunit 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133287
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  30. NM_001369111.1NP_001356040.1  activating signal cointegrator 1 complex subunit 1 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Related
    ENSP00000500906.1, ENST00000671788.1
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:133287
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain
  31. NM_001369112.1NP_001356041.1  activating signal cointegrator 1 complex subunit 1 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AC022392, AL607035
    Related
    ENSP00000320810.7, ENST00000317168.11
    Conserved Domains (2) summary
    cd02394
    Location:62120
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    cl26521
    Location:133247
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

RNA

  1. NR_045564.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 5'-most exon and lacks three internal exons, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC022392, AK298302, CD706699, DC361917

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    72096032..72218777 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448032.1XP_024303800.1  activating signal cointegrator 1 complex subunit 1 isoform X4

    Conserved Domains (2) summary
    cd02394
    Location:84142
    vigilin_like_KH; K homology RNA-binding domain_vigilin_like. The vigilin family is a large and extended family of multiple KH-domain proteins, including vigilin, also called high density lipoprotein binding protien (HBP), fungal Scp160 and bicaudal-C. Yeast Scp160p has ...
    pfam10469
    Location:155335
    AKAP7_NLS; AKAP7 2'5' RNA ligase-like domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_015947.3: Suppressed sequence

    Description
    NM_015947.3: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
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