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TMED5 transmembrane p24 trafficking protein 5 [ Homo sapiens (human) ]

Gene ID: 50999, updated on 21-Dec-2019

Summary

Official Symbol
TMED5provided by HGNC
Official Full Name
transmembrane p24 trafficking protein 5provided by HGNC
Primary source
HGNC:HGNC:24251
See related
Ensembl:ENSG00000117500 MIM:616876
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p28; p24g2; CGI-100
Expression
Ubiquitous expression in kidney (RPKM 22.0), thyroid (RPKM 21.2) and 25 other tissues See more
Orthologs

Genomic context

See TMED5 in Genome Data Viewer
Location:
1p22.1
Exon count:
6
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (93149742..93180413, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (93615299..93646246, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RN7SK pseudogene 123 Neighboring gene Sharpr-MPRA regulatory region 13810 Neighboring gene metal response element binding transcription factor 2 Neighboring gene coiled-coil domain containing 18 Neighboring gene ribosomal protein L36a pseudogene 11 Neighboring gene uncharacterized LOC107985521

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp781B2248

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
ER to Golgi vesicle-mediated transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi ribbon formation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi ribbon formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
COPII-coated ER to Golgi transport vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cis-Golgi network IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum exit site IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
endoplasmic reticulum-Golgi intermediate compartment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum-Golgi intermediate compartment membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
transmembrane emp24 domain-containing protein 5
Names
p24 family protein gamma-2
p24gamma2
transmembrane emp24 protein transport domain containing 5

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167830.2NP_001161302.1  transmembrane emp24 domain-containing protein 5 isoform 2 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) includes an alternate exon that causes a frameshift in the 3' coding region, compared to variant 1. The resulting isoform (2) has a distinct and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AC126124, AL117354, CA314982
    Consensus CDS
    CCDS53342.1
    UniProtKB/Swiss-Prot
    Q9Y3A6
    Related
    ENSP00000418992.1, ENST00000479918.5
    Conserved Domains (1) summary
    pfam01105
    Location:35162
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD
  2. NM_016040.5NP_057124.3  transmembrane emp24 domain-containing protein 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_057124.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AI436590, AL117354, BC070051, CA314982
    Consensus CDS
    CCDS743.1
    UniProtKB/Swiss-Prot
    Q9Y3A6
    Related
    ENSP00000359305.3, ENST00000370282.8
    Conserved Domains (1) summary
    pfam01105
    Location:35222
    EMP24_GP25L; emp24/gp25L/p24 family/GOLD

RNA

  1. NR_030761.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) includes an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC126124, AL117354, BX642274, CA314982

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    93149742..93180413 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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