U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Olig2 oligodendrocyte transcription factor 2 [ Mus musculus (house mouse) ]

Gene ID: 50913, updated on 11-Jun-2024

Summary

Official Symbol
Olig2provided by MGI
Official Full Name
oligodendrocyte transcription factor 2provided by MGI
Primary source
MGI:MGI:1355331
See related
Ensembl:ENSMUSG00000039830 AllianceGenome:MGI:1355331
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RK17; Olg-2; Bhlhb1; Oligo2; bHLHe19
Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; HMG box domain binding activity; and identical protein binding activity. Acts upstream of or within negative regulation of neuron differentiation; negative regulation of transcription by RNA polymerase II; and nervous system development. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; epidermis; future brain; genitourinary system; and retina. Orthologous to human OLIG2 (oligodendrocyte transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 9.5), cortex adult (RPKM 8.7) and 5 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Olig2 in Genome Data Viewer
Location:
16 C3.3; 16 52.6 cM
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91016745..91025567)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91225550..91228677)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41492 Neighboring gene predicted gene 9881 Neighboring gene STARR-seq mESC enhancer starr_41474 Neighboring gene predicted gene, 53920 Neighboring gene predicted gene, 52261 Neighboring gene oligodendrocyte transcription factor 1 Neighboring gene STARR-seq mESC enhancer starr_41475 Neighboring gene STARR-seq mESC enhancer starr_41476 Neighboring gene STARR-positive B cell enhancer ABC_E5559 Neighboring gene predicted gene, 24695

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (9)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
PubMed 
enables E-box binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables HMG box domain binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in axon development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within nervous system development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within neuron fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oligodendrocyte cell fate specification IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in sensory organ development IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within spinal cord motor neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within spinal cord oligodendrocyte cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within spinal cord oligodendrocyte cell fate specification IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within thalamus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of transcription regulator complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
oligodendrocyte transcription factor 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016967.2NP_058663.2  oligodendrocyte transcription factor 2

    See identical proteins and their annotated locations for NP_058663.2

    Status: VALIDATED

    Source sequence(s)
    BC051967
    Consensus CDS
    CCDS28323.1
    UniProtKB/Swiss-Prot
    Q9EQW6, Q9JKN4
    UniProtKB/TrEMBL
    Q542S0
    Related
    ENSMUSP00000036797.9, ENSMUST00000035608.10
    Conserved Domains (1) summary
    cd18940
    Location:95179
    bHLH_TS_OLIG2; basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 2 (Oligo2) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    91016745..91025567
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036160000.1XP_036015893.1  oligodendrocyte transcription factor 2 isoform X1

    UniProtKB/Swiss-Prot
    Q9EQW6, Q9JKN4
    UniProtKB/TrEMBL
    Q542S0
    Conserved Domains (1) summary
    cd18940
    Location:95179
    bHLH_TS_OLIG2; basic helix-loop-helix (bHLH) domain found in oligodendrocyte transcription factor 2 (Oligo2) and similar proteins