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Preb prolactin regulatory element binding [ Mus musculus (house mouse) ]

Gene ID: 50907, updated on 1-Mar-2024

Summary

Official Symbol
Prebprovided by MGI
Official Full Name
prolactin regulatory element bindingprovided by MGI
Primary source
MGI:MGI:1355326
See related
Ensembl:ENSMUSG00000045302 AllianceGenome:MGI:1355326
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables GTPase binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in several processes, including COPII vesicle coating; protein transport; and regulation of COPII vesicle coating. Predicted to act upstream of or within protein transport and vesicle-mediated transport. Predicted to be located in endoplasmic reticulum exit site and nucleus. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in several structures, including central nervous system; embryo mesenchyme; jaw; metanephros; and surface ectoderm. Orthologous to human PREB (prolactin regulatory element binding). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 35.0), large intestine adult (RPKM 34.4) and 28 other tissues See more
Orthologs
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Genomic context

See Preb in Genome Data Viewer
Location:
5 B1; 5 16.9 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31109011..31117700, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30951667..30960356, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E4749 Neighboring gene ketohexokinase Neighboring gene cell growth regulator with EF hand domain 1 Neighboring gene STARR-positive B cell enhancer ABC_E1679 Neighboring gene abhydrolase domain containing 1 Neighboring gene transcription factor 23 Neighboring gene STARR-seq mESC enhancer starr_12765 Neighboring gene solute carrier family 5 (sodium-dependent vitamin transporter), member 6 Neighboring gene STARR-positive B cell enhancer ABC_E2741 Neighboring gene all-trans retinoic acid induced differentiation factor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables GTPase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
NOT enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 
located_in endoplasmic reticulum exit site ISO
Inferred from Sequence Orthology
more info
 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
prolactin regulatory element-binding protein
Names
mammalian guanine nucleotide exchange factor mSec12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001294302.1NP_001281231.1  prolactin regulatory element-binding protein isoform 2

    See identical proteins and their annotated locations for NP_001281231.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 3' coding region, resulting in a frameshift and an early stop codon, compared to variant 1. It encodes isoform 2, which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK013330, AK029838, AK151288, BP765513, CJ145010
    Consensus CDS
    CCDS80244.1
    UniProtKB/TrEMBL
    D3Z3S1
    Related
    ENSMUSP00000144263.2, ENSMUST00000202567.2
    Conserved Domains (3) summary
    COG2319
    Location:140327
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:160194
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:159327
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. NM_001422185.1NP_001409114.1  prolactin regulatory element-binding protein isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC109606
  3. NM_016703.3NP_057912.2  prolactin regulatory element-binding protein isoform 1

    See identical proteins and their annotated locations for NP_057912.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encode the longer isoform (1).
    Source sequence(s)
    AK013330, AK029838, AK151288, BP765513, CJ145010
    Consensus CDS
    CCDS39051.1
    UniProtKB/Swiss-Prot
    Q9QZ99, Q9WUQ2
    UniProtKB/TrEMBL
    Q3UAP1
    Related
    ENSMUSP00000074387.6, ENSMUST00000074840.12
    Conserved Domains (2) summary
    sd00039
    Location:160194
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:159353
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. NR_185490.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC109606
  2. NR_185491.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC109606

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    31109011..31117700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504015.2XP_006504078.1  prolactin regulatory element-binding protein isoform X3

    Conserved Domains (2) summary
    sd00039
    Location:153193
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:159231
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  2. XM_036165264.1XP_036021157.1  prolactin regulatory element-binding protein isoform X1

    Conserved Domains (2) summary
    sd00039
    Location:153193
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:159231
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
  3. XM_006504017.4XP_006504080.1  prolactin regulatory element-binding protein isoform X4

    Conserved Domains (2) summary
    sd00039
    Location:153193
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:159231
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RNA

  1. XR_004942534.1 RNA Sequence

  2. XR_004942536.1 RNA Sequence