Format

Send to:

Choose Destination

Nckap1 NCK-associated protein 1 [ Mus musculus (house mouse) ]

Gene ID: 50884, updated on 9-Sep-2018

Summary

Official Symbol
Nckap1provided by MGI
Official Full Name
NCK-associated protein 1provided by MGI
Primary source
MGI:MGI:1355333
See related
Ensembl:ENSMUSG00000027002 Vega:OTTMUSG00000013373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H19; Hem2; Nap1; mh19; Hem-2; C79304; p125Nap1; mKIAA0587
Expression
Ubiquitous expression in cortex adult (RPKM 59.6), frontal lobe adult (RPKM 57.9) and 26 other tissues See more
Orthologs

Genomic context

See Nckap1 in Genome Data Viewer
Location:
2 C3; 2 48.21 cM
Exon count:
32
Annotation release Status Assembly Chr Location
106 current GRCm38.p4 (GCF_000001635.24) 2 NC_000068.7 (80500512..80581299, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (80341452..80421122, complement)

Chromosome 2 - NC_000068.7Genomic Context describing neighboring genes Neighboring gene frizzled-related protein Neighboring gene mitochondrial ribosomal protein S36 pseudogene Neighboring gene N-glycanase 1 pseudogene Neighboring gene predicted gene 13688 Neighboring gene dual specificity phosphatase 19 Neighboring gene microRNA 684-1 Neighboring gene SMT3 suppressor of mif two 3 homolog 2 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to Rac GTPase binding ISO
Inferred from Sequence Orthology
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
Rac protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
apical protein localization IDA
Inferred from Direct Assay
more info
PubMed 
basal protein localization IDA
Inferred from Direct Assay
more info
PubMed 
cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell migration involved in gastrulation IMP
Inferred from Mutant Phenotype
more info
PubMed 
cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell projection assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cortical actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic foregut morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
embryonic heart tube development IMP
Inferred from Mutant Phenotype
more info
PubMed 
endoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment or maintenance of actin cytoskeleton polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
lamellipodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
lamellipodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
mesodermal cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
notochord development IMP
Inferred from Mutant Phenotype
more info
PubMed 
notochord morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
paraxial mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
paraxial mesoderm morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of Arp2/3 complex-mediated actin nucleation ISO
Inferred from Sequence Orthology
more info
 
positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of lamellipodium assembly IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of lamellipodium assembly ISO
Inferred from Sequence Orthology
more info
 
protein stabilization IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
somitogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
zygotic determination of anterior/posterior axis, embryo IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
SCAR complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SCAR complex ISO
Inferred from Sequence Orthology
more info
 
cell projection IEA
Inferred from Electronic Annotation
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
filamentous actin IDA
Inferred from Direct Assay
more info
PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
lamellipodium IDA
Inferred from Direct Assay
more info
PubMed 
membrane IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 
postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
ruffle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nck-associated protein 1
Names
brain protein H19
membrane-associated protein HEM-2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290745.1NP_001277674.1  nck-associated protein 1 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC060197, BC127067, BP764873, BU055892
    Consensus CDS
    CCDS71082.1
    UniProtKB/TrEMBL
    A1L0U6, A2AS98
    Related
    ENSMUSP00000107390.2, OTTMUSP00000014352, ENSMUST00000111760.2, OTTMUST00000032325
    Conserved Domains (1) summary
    pfam09735
    Location:131128
    Nckap1; Membrane-associated apoptosis protein
  2. NM_001355410.1NP_001342339.1  nck-associated protein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice junction in the 5' end compared to variant 1, resulting in an isoform (c) that is shorter compared to isoform a.
    Source sequence(s)
    AL928578
    Conserved Domains (1) summary
    pfam09735
    Location:131126
    Nckap1; Membrane-associated apoptosis protein
  3. NM_001355411.1NP_001342340.1  nck-associated protein 1 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and uses an alternate in-frame splice junction in the 5' end compared to variant 1, resulting in an isoform (d) that is shorter compared to isoform a.
    Source sequence(s)
    AL928578
    Conserved Domains (1) summary
    pfam09735
    Location:131120
    Nckap1; Membrane-associated apoptosis protein
  4. NM_016965.3NP_058661.1  nck-associated protein 1 isoform b

    See identical proteins and their annotated locations for NP_058661.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' end compared to variant 1, resulting in an isoform (b) that is shorter compared to isoform a.
    Source sequence(s)
    AJ534525, BC060197, BP764873, BU055892
    Consensus CDS
    CCDS16177.1
    UniProtKB/Swiss-Prot
    P28660
    Related
    ENSMUSP00000028386.5, OTTMUSP00000014351, ENSMUST00000028386.11, OTTMUST00000032324
    Conserved Domains (1) summary
    pfam09735
    Location:131122
    Nckap1; Membrane-associated apoptosis protein

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm38.p4 C57BL/6J

Genomic

  1. NC_000068.7 Reference GRCm38.p4 C57BL/6J

    Range
    80500512..80581299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499882.2XP_006499945.1  nck-associated protein 1 isoform X2

    Conserved Domains (1) summary
    pfam09735
    Location:131120
    Nckap1; Membrane-associated apoptosis protein
  2. XM_006499881.3XP_006499944.1  nck-associated protein 1 isoform X1

    Conserved Domains (1) summary
    pfam09735
    Location:131126
    Nckap1; Membrane-associated apoptosis protein
Support Center