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Stag3 STAG3 cohesin complex component [ Mus musculus (house mouse) ]

Gene ID: 50878, updated on 5-Mar-2024

Summary

Official Symbol
Stag3provided by MGI
Official Full Name
STAG3 cohesin complex componentprovided by MGI
Primary source
MGI:MGI:1355311
See related
Ensembl:ENSMUSG00000036928 AllianceGenome:MGI:1355311
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
SA-2
Summary
Predicted to enable chromatin binding activity. Acts upstream of or within homologous chromosome pairing at meiosis and protein localization to chromosome. Located in lateral element; male germ cell nucleus; and transverse filament. Part of nuclear meiotic cohesin complex. Is expressed in bone marrow; brain; and genitourinary system. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 8. Orthologous to human STAG3 (stromal antigen 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 51.9), CNS E18 (RPKM 4.9) and 3 other tissues See more
Orthologs
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Genomic context

See Stag3 in Genome Data Viewer
Location:
5 G2; 5 77.01 cM
Exon count:
35
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138270757..138310659)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138272514..138312397)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E532 Neighboring gene RIKEN cDNA 6330418K02 gene Neighboring gene STARR-positive B cell enhancer ABC_E4800 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 Neighboring gene trafficking protein particle complex 14 Neighboring gene galactose-3-O-sulfotransferase 4 Neighboring gene STARR-positive B cell enhancer ABC_E3630 Neighboring gene glypican 2 cerebroglycan Neighboring gene poliovirus receptor related immunoglobulin domain containing, pseudogene Neighboring gene poliovirus receptor related immunoglobulin domain containing Neighboring gene glutamatic-oxaloacetic transaminase 2, mitochondrial, pseudogene 1 Neighboring gene predicted gene 10874

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transgenic (1) 
  • Targeted (4) 
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
part_of chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
 
located_in condensed nuclear chromosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in lateral element IDA
Inferred from Direct Assay
more info
PubMed 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
part_of meiotic cohesin complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of meiotic cohesin complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of meiotic cohesin complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
located_in synaptonemal complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in transverse filament IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
cohesin subunit SA-3
Names
SCC3 homolog 3
stromal antigen 3
stromalin-3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016964.2NP_058660.2  cohesin subunit SA-3

    See identical proteins and their annotated locations for NP_058660.2

    Status: VALIDATED

    Source sequence(s)
    AJ005678, BC060184
    Consensus CDS
    CCDS39344.1
    UniProtKB/Swiss-Prot
    B2RSV0, O70576
    Related
    ENSMUSP00000040945.9, ENSMUST00000048028.15
    Conserved Domains (1) summary
    pfam08514
    Location:188296
    STAG; STAG domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    138270757..138310659
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011240948.4XP_011239250.1  cohesin subunit SA-3 isoform X1

    See identical proteins and their annotated locations for XP_011239250.1

    UniProtKB/Swiss-Prot
    B2RSV0, O70576
    Conserved Domains (1) summary
    pfam08514
    Location:188296
    STAG; STAG domain
  2. XM_006504596.4XP_006504659.1  cohesin subunit SA-3 isoform X1

    See identical proteins and their annotated locations for XP_006504659.1

    UniProtKB/Swiss-Prot
    B2RSV0, O70576
    Conserved Domains (1) summary
    pfam08514
    Location:188296
    STAG; STAG domain
  3. XM_017320971.3XP_017176460.1  cohesin subunit SA-3 isoform X3

    Conserved Domains (1) summary
    pfam08514
    Location:188296
    STAG; STAG domain
  4. XM_017320972.3XP_017176461.1  cohesin subunit SA-3 isoform X3

    Conserved Domains (1) summary
    pfam08514
    Location:188296
    STAG; STAG domain
  5. XM_006504601.1XP_006504664.1  cohesin subunit SA-3 isoform X2

    See identical proteins and their annotated locations for XP_006504664.1

  6. XM_006504600.1XP_006504663.1  cohesin subunit SA-3 isoform X2

    See identical proteins and their annotated locations for XP_006504663.1

RNA

  1. XR_004942532.1 RNA Sequence

  2. XR_377146.4 RNA Sequence