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HEBP1 heme binding protein 1 [ Homo sapiens (human) ]

Gene ID: 50865, updated on 5-Jan-2020

Summary

Official Symbol
HEBP1provided by HGNC
Official Full Name
heme binding protein 1provided by HGNC
Primary source
HGNC:HGNC:17176
See related
Ensembl:ENSG00000013583 MIM:605826
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HBP; HEBP
Summary
The full-length protein encoded by this gene is an intracellular tetrapyrrole-binding protein. This protein includes a natural chemoattractant peptide of 21 amino acids at the N-terminus, which is a natural ligand for formyl peptide receptor-like receptor 2 (FPRL2) and promotes calcium mobilization and chemotaxis in monocytes and dendritic cells. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in duodenum (RPKM 103.7), small intestine (RPKM 72.8) and 25 other tissues See more
Orthologs

Genomic context

See HEBP1 in Genome Data Viewer
Location:
12p13.1
Exon count:
4
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (12974870..13000265, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (13127798..13153243, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene G protein-coupled receptor class C group 5 member A Neighboring gene microRNA 614 Neighboring gene GPRC5D and HEBP1 antisense RNA 1 Neighboring gene G protein-coupled receptor class C group 5 member D Neighboring gene 5-hydroxytryptamine receptor 7 pseudogene 1 Neighboring gene ribosomal protein S26 pseudogene 46

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heme binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heme binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
circadian rhythm TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
heme-binding protein 1
Names
p22HBP

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015987.5NP_057071.2  heme-binding protein 1

    See identical proteins and their annotated locations for NP_057071.2

    Status: REVIEWED

    Source sequence(s)
    AC007688, AW452041, CF126276
    Consensus CDS
    CCDS31749.1
    UniProtKB/Swiss-Prot
    Q9NRV9
    UniProtKB/TrEMBL
    A0A024RAS8
    Related
    ENSP00000014930.4, ENST00000014930.9
    Conserved Domains (1) summary
    pfam04832
    Location:13187
    SOUL; SOUL heme-binding protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    12974870..13000265 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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