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VILL villin like [ Homo sapiens (human) ]

Gene ID: 50853, updated on 5-May-2019

Summary

Official Symbol
VILLprovided by HGNC
Official Full Name
villin likeprovided by HGNC
Primary source
HGNC:HGNC:30906
See related
Ensembl:ENSG00000136059
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
The protein encoded by this gene belongs to the villin/gelsolin family. It contains 6 gelsolin-like repeats and a headpiece domain. It may play a role in actin-bundling. [provided by RefSeq, Jul 2008]
Expression
Broad expression in stomach (RPKM 21.1), small intestine (RPKM 13.2) and 17 other tissues See more
Orthologs

Genomic context

See VILL in Genome Data Viewer
Location:
3p22.2
Exon count:
23
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (37987974..38007188)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (38032217..38048676)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene CTD small phosphatase like Neighboring gene HNF1 motif-containing MPRA enhancer 248 Neighboring gene microRNA 26a-1 Neighboring gene phospholipase C delta 1 Neighboring gene protein phosphatase 2 regulatory subunit Bdelta pseudogene 1 Neighboring gene DLEC1 cilia and flagella associated protein

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
actin filament binding IEA
Inferred from Electronic Annotation
more info
 
structural constituent of cytoskeleton TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
actin filament capping IEA
Inferred from Electronic Annotation
more info
 
cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
actin cytoskeleton TAS
Traceable Author Statement
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001370264.1NP_001357193.1  villin-like protein isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC105752, AC144536
  2. NM_001370265.1NP_001357194.1  villin-like protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC105752, AC144536
  3. NM_015873.3NP_056957.3  villin-like protein

    See identical proteins and their annotated locations for NP_056957.3

    Status: REVIEWED

    Source sequence(s)
    BC000243, BC004300, D88154
    Consensus CDS
    CCDS2670.2
    UniProtKB/Swiss-Prot
    O15195
    Related
    ENSP00000373266.2, ENST00000383759.6
    Conserved Domains (7) summary
    smart00153
    Location:821856
    VHP; Villin headpiece domain
    cd11288
    Location:506596
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135228
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:6119
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:611706
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:248346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:385485
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

RNA

  1. NR_163266.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC105752, AC144536
  2. NR_163267.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC105752, AC144536

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    37987974..38007188
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533773.2XP_011532075.1  villin-like protein isoform X3

    Conserved Domains (4) summary
    cd11289
    Location:135228
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:6119
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:248346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:385485
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  2. XM_011533770.2XP_011532072.1  villin-like protein isoform X1

    See identical proteins and their annotated locations for XP_011532072.1

    UniProtKB/Swiss-Prot
    O15195
    Related
    ENSP00000283713.6, ENST00000283713.10
    Conserved Domains (7) summary
    smart00153
    Location:821856
    VHP; Villin headpiece domain
    cd11288
    Location:506596
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135228
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:6119
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:611706
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:248346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:385485
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  3. XM_011533771.1XP_011532073.1  villin-like protein isoform X2

    Conserved Domains (6) summary
    cd11288
    Location:506596
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135228
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:6119
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:248346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:385485
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    cl15697
    Location:611650
    ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains
  4. XM_005265191.3XP_005265248.1  villin-like protein isoform X1

    See identical proteins and their annotated locations for XP_005265248.1

    UniProtKB/Swiss-Prot
    O15195
    Conserved Domains (7) summary
    smart00153
    Location:821856
    VHP; Villin headpiece domain
    cd11288
    Location:506596
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135228
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:6119
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:611706
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:248346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:385485
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  5. XM_006713184.3XP_006713247.1  villin-like protein isoform X1

    See identical proteins and their annotated locations for XP_006713247.1

    UniProtKB/Swiss-Prot
    O15195
    Conserved Domains (7) summary
    smart00153
    Location:821856
    VHP; Villin headpiece domain
    cd11288
    Location:506596
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135228
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:6119
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:611706
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:248346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:385485
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
  6. XM_005265192.4XP_005265249.1  villin-like protein isoform X1

    See identical proteins and their annotated locations for XP_005265249.1

    UniProtKB/Swiss-Prot
    O15195
    Conserved Domains (7) summary
    smart00153
    Location:821856
    VHP; Villin headpiece domain
    cd11288
    Location:506596
    gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
    cd11289
    Location:135228
    gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
    cd11290
    Location:6119
    gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
    cd11291
    Location:611706
    gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
    cd11292
    Location:248346
    gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
    cd11293
    Location:385485
    gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

RNA

  1. XR_940431.3 RNA Sequence

  2. XR_001740160.1 RNA Sequence

  3. XR_001740161.1 RNA Sequence

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