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TRAT1 T cell receptor associated transmembrane adaptor 1 [ Homo sapiens (human) ]

Gene ID: 50852, updated on 9-Jun-2025
Official Symbol
TRAT1provided by HGNC
Official Full Name
T cell receptor associated transmembrane adaptor 1provided by HGNC
Primary source
HGNC:HGNC:30698
See related
Ensembl:ENSG00000163519 MIM:604962; AllianceGenome:HGNC:30698
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRIM; TCRIM; HSPC062; pp29/30
Summary
Predicted to enable transmembrane receptor protein tyrosine kinase adaptor activity. Acts upstream of or within negative regulation of receptor recycling; negative regulation of transport; and positive regulation of signal transduction. Located in centriolar satellite; mitotic spindle; and plasma membrane. Part of T cell receptor complex. [provided by Alliance of Genome Resources, Jun 2025]
Expression
Biased expression in lymph node (RPKM 11.9), appendix (RPKM 6.4) and 9 other tissues See more
Orthologs
mouse all
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See TRAT1 in Genome Data Viewer
Location:
3q13.13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (108822786..108855005)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (111543021..111575233)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108541633..108573852)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374034 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:108462949-108464148 Neighboring gene resistin like beta Neighboring gene guanylate cyclase activator 1C Neighboring gene MORC family CW-type zinc finger 1 Neighboring gene small nucleolar RNA U3

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. The Roles and Mechanisms of TRAT1 in the Progression of Non-Small Cell Lung Cancer. Guo Q, et al. Curr Med Sci, 2022 Dec. PMID 36184729
  2. Genomic organization and chromosomal localization of the human gene encoding the T-cell receptor-interacting molecule (TRIM). Hübener C, et al. Immunogenetics, 2000 Feb. PMID 10663578
  3. The role of membrane-associated adaptors in T cell receptor signalling. Zhang W, et al. Semin Immunol, 2000 Feb. PMID 10723796
  4. Human leukocyte antigen class I-restricted immunosuppression by human CD8+ regulatory T cells requires CTLA-4-mediated interaction with dendritic cells. Jarvis LB, et al. Hum Immunol, 2008 Nov. PMID 18817831
  5. TRIM proteins in therapeutic membrane repair of muscular dystrophy. Alloush J, et al. JAMA Neurol, 2013 Jul. PMID 23699904, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Roles and Mechanisms of TRAT1 in the Progression of Non-Small Cell Lung Cancer.
    Title: The Roles and Mechanisms of TRAT1 in the Progression of Non-Small Cell Lung Cancer.
  2. TRIM acts to chaperone CTLA-4 transport to the cell surface; this function would be required to account for the phenotypic and functional properties of CD8(+) Tregs.
    Title: Human leukocyte antigen class I-restricted immunosuppression by human CD8+ regulatory T cells requires CTLA-4-mediated interaction with dendritic cells.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
  
enables transmembrane receptor protein tyrosine kinase adaptor activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular defense response TAS
Traceable Author Statement
more info
 PubMed 
involved_in immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of receptor recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of receptor recycling IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of T cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of T cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of calcium-mediated signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of T cell receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of T cell receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in centriolar satellite IDA
Inferred from Direct Assay
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitotic spindle IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
Preferred Names
T-cell receptor-associated transmembrane adapter 1
Names
T cell receptor interacting molecule

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317747.2 → NP_001304676.1  T-cell receptor-associated transmembrane adapter 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AJ240085, AK291991, AV735609, BC025713
    Consensus CDS
    CCDS82814.1
    UniProtKB/TrEMBL
    C9JF66
    Related
    ENSP00000410097.1, ENST00000426646.1
    Conserved Domains (1) summary
    pfam15330
    Location:3 → 83
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

  2. NM_016388.4 → NP_057472.2  T-cell receptor-associated transmembrane adapter 1 isoform 1

    See identical proteins and their annotated locations for NP_057472.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK291991, AV735609, BC025713
    Consensus CDS
    CCDS33813.1
    UniProtKB/Swiss-Prot
    Q6PIZ9, Q9NZX5
    Related
    ENSP00000295756.6, ENST00000295756.11
    Conserved Domains (1) summary
    pfam15330
    Location:23 → 120
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    108822786..108855005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    111543021..111575233
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PIZ9.1 GenPept UniProtKB/Swiss-Prot:Q6PIZ9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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