Format

Send to:

Choose Destination

TRAT1 T cell receptor associated transmembrane adaptor 1 [ Homo sapiens (human) ]

Gene ID: 50852, updated on 7-Jun-2020

Summary

Official Symbol
TRAT1provided by HGNC
Official Full Name
T cell receptor associated transmembrane adaptor 1provided by HGNC
Primary source
HGNC:HGNC:30698
See related
Ensembl:ENSG00000163519 MIM:604962
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRIM; TCRIM; HSPC062; pp29/30
Expression
Biased expression in lymph node (RPKM 11.9), appendix (RPKM 6.4) and 9 other tissues See more
Orthologs

Genomic context

See TRAT1 in Genome Data Viewer
Location:
3q13.13
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (108822786..108855005)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108541631..108573714)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374034 Neighboring gene resistin like beta Neighboring gene guanylate cyclase activator 1C Neighboring gene MORC family CW-type zinc finger 1 Neighboring gene MORC1 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
transmembrane receptor protein tyrosine kinase adaptor activity TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
T cell receptor complex IDA
Inferred from Direct Assay
more info
PubMed 
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
T-cell receptor-associated transmembrane adapter 1
Names
T cell receptor interacting molecule

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317747.2NP_001304676.1  T-cell receptor-associated transmembrane adapter 1 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AJ240085, AK291991, AV735609, BC025713
    Consensus CDS
    CCDS82814.1
    UniProtKB/Swiss-Prot
    Q6PIZ9
    UniProtKB/TrEMBL
    C9JF66
    Related
    ENSP00000410097.1, ENST00000426646.1
    Conserved Domains (1) summary
    pfam15330
    Location:383
    SIT; SHP2-interacting transmembrane adaptor protein, SIT
  2. NM_016388.4NP_057472.2  T-cell receptor-associated transmembrane adapter 1 isoform 1

    See identical proteins and their annotated locations for NP_057472.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK291991, AV735609, BC025713
    Consensus CDS
    CCDS33813.1
    UniProtKB/Swiss-Prot
    Q6PIZ9
    Related
    ENSP00000295756.6, ENST00000295756.11
    Conserved Domains (1) summary
    pfam15330
    Location:23120
    SIT; SHP2-interacting transmembrane adaptor protein, SIT

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    108822786..108855005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center