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COPS7A COP9 signalosome subunit 7A [ Homo sapiens (human) ]

Gene ID: 50813, updated on 1-Aug-2020

Summary

Official Symbol
COPS7Aprovided by HGNC
Official Full Name
COP9 signalosome subunit 7Aprovided by HGNC
Primary source
HGNC:HGNC:16758
See related
Ensembl:ENSG00000111652 MIM:616009
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CSN7; CSN7A; SGN7a
Summary
This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]
Expression
Ubiquitous expression in brain (RPKM 27.2), thyroid (RPKM 23.7) and 25 other tissues See more
Orthologs

Genomic context

See COPS7A in Genome Data Viewer
Location:
12p13.31
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (6724046..6731868)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (6833150..6841041)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene PILR alpha associated neural protein Neighboring gene RNA, U6 small nuclear 781, pseudogene Neighboring gene myeloid leukemia factor 2 Neighboring gene parathymosin

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC110877

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
COP9 signalosome assembly IEA
Inferred from Electronic Annotation
more info
 
nucleotide-excision repair, DNA damage recognition TAS
Traceable Author Statement
more info
 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein deneddylation IDA
Inferred from Direct Assay
more info
PubMed 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
COP9 signalosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
COP9 signalosome IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
COP9 signalosome complex subunit 7a
Names
COP9 complex subunit 7a
COP9 constitutive photomorphogenic homolog subunit 7A
JAB1-containing signalosome subunit 7a
dermal papilla-derived protein 10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034023.1 RefSeqGene

    Range
    5063..12882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001164093.2NP_001157565.1  COP9 signalosome complex subunit 7a

    See identical proteins and their annotated locations for NP_001157565.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AK292621, BC011789, BQ008460, DC355036
    Consensus CDS
    CCDS8558.1
    UniProtKB/Swiss-Prot
    Q9UBW8
    Related
    ENSP00000446039.1, ENST00000534947.5
    Conserved Domains (1) summary
    smart00753
    Location:87177
    PAM; PCI/PINT associated module
  2. NM_001164094.2NP_001157566.1  COP9 signalosome complex subunit 7a

    See identical proteins and their annotated locations for NP_001157566.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    BC011789, BQ008460, DA043679
    Consensus CDS
    CCDS8558.1
    UniProtKB/Swiss-Prot
    Q9UBW8
    Related
    ENSP00000438115.1, ENST00000543155.6
    Conserved Domains (1) summary
    smart00753
    Location:87177
    PAM; PCI/PINT associated module
  3. NM_001164095.3NP_001157567.1  COP9 signalosome complex subunit 7a

    See identical proteins and their annotated locations for NP_001157567.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AB014764, AC125494, BC011789, BQ008460, HY087807
    Consensus CDS
    CCDS8558.1
    UniProtKB/Swiss-Prot
    Q9UBW8
    Related
    ENSP00000441852.1, ENST00000539735.5
    Conserved Domains (1) summary
    smart00753
    Location:87177
    PAM; PCI/PINT associated module
  4. NM_016319.4NP_057403.1  COP9 signalosome complex subunit 7a

    See identical proteins and their annotated locations for NP_057403.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC125494, AF210052, BC011789, BQ008460
    Consensus CDS
    CCDS8558.1
    UniProtKB/Swiss-Prot
    Q9UBW8
    Related
    ENSP00000229251.3, ENST00000229251.7
    Conserved Domains (1) summary
    smart00753
    Location:87177
    PAM; PCI/PINT associated module

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    6724046..6731868
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005253694.2XP_005253751.1  COP9 signalosome complex subunit 7a isoform X1

    See identical proteins and their annotated locations for XP_005253751.1

    UniProtKB/Swiss-Prot
    Q9UBW8
    Related
    ENSP00000438363.1, ENST00000534877.5
    Conserved Domains (1) summary
    smart00753
    Location:87177
    PAM; PCI/PINT associated module
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