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HDGFL3 HDGF like 3 [ Homo sapiens (human) ]

Gene ID: 50810, updated on 7-Dec-2018

Summary

Official Symbol
HDGFL3provided by HGNC
Official Full Name
HDGF like 3provided by HGNC
Primary source
HGNC:HGNC:24937
See related
Ensembl:ENSG00000166503 MIM:616643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HDGF2; HRP-3; HDGF-2; CGI-142; HDGFRP3
Expression
Broad expression in testis (RPKM 18.5), brain (RPKM 17.0) and 22 other tissues See more
Orthologs

Genomic context

See HDGFL3 in Genome Data Viewer
Location:
15q25.2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 15 NC_000015.10 (83112738..83208018, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (83806804..83876770, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene BTB domain containing 1 Neighboring gene fatty acid binding protein 5 pseudogene 8 Neighboring gene microRNA 4515 Neighboring gene transmembrane 6 superfamily member 1 Neighboring gene uncharacterized LOC105370932 Neighboring gene basonuclin 1 Neighboring gene uncharacterized LOC105370933

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
growth factor activity IEA
Inferred from Electronic Annotation
more info
 
microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
tubulin binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cell proliferation NAS
Non-traceable Author Statement
more info
PubMed 
microtubule polymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of microtubule depolymerization ISS
Inferred from Sequence or Structural Similarity
more info
 
neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
extracellular region HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
hepatoma-derived growth factor-related protein 3
Names
hepatoma-derived growth factor 2
hepatoma-derived growth factor, related protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016073.4NP_057157.1  hepatoma-derived growth factor-related protein 3

    See identical proteins and their annotated locations for NP_057157.1

    Status: VALIDATED

    Source sequence(s)
    AA725615, AC024270, AC103876, BC015483, BC040554
    Consensus CDS
    CCDS32314.1
    UniProtKB/Swiss-Prot
    Q9Y3E1
    UniProtKB/TrEMBL
    A0A024R216
    Related
    ENSP00000299633.4, ENST00000299633.6
    Conserved Domains (1) summary
    cd05834
    Location:791
    HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p12 Primary Assembly

    Range
    83112738..83208018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006720554.4XP_006720617.1  hepatoma-derived growth factor-related protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006720617.1

    Conserved Domains (1) summary
    cd05834
    Location:791
    HDGF_related; The PWWP domain is an essential part of the Hepatoma Derived Growth Factor (HDGF) family of proteins, and is necessary for DNA binding by HDGF. This family of endogenous nuclear-targeted mitogens includes HRP (HDGF-related proteins 1, 2, 3, 4, or HPR1, ...

RNA

  1. XR_001751298.2 RNA Sequence

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