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ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [ Homo sapiens (human) ]

Gene ID: 50807, updated on 2-Oct-2018

Summary

Official Symbol
ASAP1provided by HGNC
Official Full Name
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1provided by HGNC
Primary source
HGNC:HGNC:2720
See related
Ensembl:ENSG00000153317 MIM:605953; Vega:OTTHUMG00000164772
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAP; PAG2; AMAP1; DDEF1; ZG14P; CENTB4
Summary
This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 18.3), spleen (RPKM 15.5) and 24 other tissues See more
Orthologs

Genomic context

See ASAP1 in Genome Data Viewer
Location:
8q24.21-q24.22
Exon count:
37
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 8 NC_000008.11 (130052104..130443848, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (131064350..131455906, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 49 member B Neighboring gene RNA, U7 small nuclear 181 pseudogene Neighboring gene microRNA 5194 Neighboring gene RNA, U6 small nuclear 1255, pseudogene Neighboring gene ASAP1 intronic transcript 2 Neighboring gene ASAP1 intronic transcript 1 Neighboring gene uncharacterized LOC105375758 Neighboring gene NFE2L2 motif-containing MPRA enhancer 239

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
NHGRI GWA Catalog

Pathways from BioSystems

  • Arf1 pathway, organism-specific biosystem (from Pathway Interaction Database)
    Arf1 pathway, organism-specific biosystem
    Arf1 pathway
  • Cargo trafficking to the periciliary membrane, organism-specific biosystem (from REACTOME)
    Cargo trafficking to the periciliary membrane, organism-specific biosystemProteomic studies suggest that the cilium is home to approximately a thousand proteins, and has a unique protein and lipid make up relative to the bulk cytoplasm and plasma membrane (Pazour et al, 20...
  • Cilium Assembly, organism-specific biosystem (from REACTOME)
    Cilium Assembly, organism-specific biosystemCilia are membrane covered organelles that extend from the surface of eukaryotic cells. Cilia may be motile, such as respiratory cilia) or non-motile (such as the primary cilium) and are distinguishe...
  • EGF/EGFR Signaling Pathway, organism-specific biosystem (from WikiPathways)
    EGF/EGFR Signaling Pathway, organism-specific biosystemEpidermal growth factor receptor (EGFR) also known as ErbB1/HER1 is a member of the ErbB family of receptor tyrosine kinases which also includes ErbB2 (Neu, HER2), ErbB3 (HER3) and ErbB4 (HER4). Sev...
  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Fc gamma R-mediated phagocytosis, organism-specific biosystem (from KEGG)
    Fc gamma R-mediated phagocytosis, organism-specific biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
  • Fc gamma R-mediated phagocytosis, conserved biosystem (from KEGG)
    Fc gamma R-mediated phagocytosis, conserved biosystemPhagocytosis plays an essential role in host-defense mechanisms through the uptake and destruction of infectious pathogens. Specialized cell types including macrophages, neutrophils, and monocytes ta...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...
  • Signaling events mediated by focal adhesion kinase, organism-specific biosystem (from Pathway Interaction Database)
    Signaling events mediated by focal adhesion kinase, organism-specific biosystem
    Signaling events mediated by focal adhesion kinase
  • VxPx cargo-targeting to cilium, organism-specific biosystem (from REACTOME)
    VxPx cargo-targeting to cilium, organism-specific biosystemA number of membrane proteins destined for the ciliary membrane are recognized by ARF4 in the trans-Golgi network, initiating the formation of a ciliary targeting complex that directs the passage of ...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1249

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
cadherin binding HDA PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-3,4,5-trisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
phosphatidylserine binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of dendritic spine development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 
positive regulation of membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of podosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cell projection membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
dendritic spine IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
podosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Names
130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein
130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein
ADP-ribosylation factor-directed GTPase-activating protein 1
ARF GTPase-activating protein 1
DEF-1
PIP2-dependent ARF1 GAP
centaurin, beta 4
development and differentiation-enhancing factor 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030354.1 RefSeqGene

    Range
    5001..396557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001247996.1NP_001234925.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001234925.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional exon (with an in-frame AUG) in the 5' region compared to variant 1. This results in translation initiation from an alternate start site, and a shorter isoform (2) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB033075, AI494058, BC144493, DA319233
    Consensus CDS
    CCDS75788.1
    UniProtKB/Swiss-Prot
    Q9ULH1
    UniProtKB/TrEMBL
    A0A0A0MRE5
    Related
    ENSP00000350297.2, ENST00000357668.2
    Conserved Domains (8) summary
    cd07641
    Location:47261
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10641120
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:594682
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:309415
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:319404
    PH; PH domain
    pfam01412
    Location:432548
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:575660
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:594627
    ANK; ANK repeat [structural motif]
  2. NM_001362924.1NP_001349853.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AB033075, AI494058, BC144493, BQ645913, DA315979, DA319233, DA416332
    Conserved Domains (7) summary
    cd07641
    Location:54268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10741130
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:604692
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:319425
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:604637
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:442558
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:7271063
    Atrophin-1; Atrophin-1 family
  3. NM_001362925.1NP_001349854.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AB033075, AI494058, BC144493, BG748866, DA315979, DA319233, DA416332
    Conserved Domains (7) summary
    cd07641
    Location:54268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10171073
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:604692
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:319425
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:604637
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:442558
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:7301006
    Atrophin-1; Atrophin-1 family
  4. NM_001362926.1NP_001349855.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AB033075, AI494058, BC144493, BG118567, BG748866, DA315979, DA319233, DA416332
    Conserved Domains (7) summary
    cd07641
    Location:54268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10141070
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:601689
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:316422
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:601634
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:439555
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:7271003
    Atrophin-1; Atrophin-1 family
  5. NM_018482.3NP_060952.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_060952.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
    Source sequence(s)
    AB033075, AI494058, BC137135, DA319233
    Consensus CDS
    CCDS6362.1
    UniProtKB/Swiss-Prot
    Q9ULH1
    Related
    ENSP00000429900.1, OTTHUMP00000227440, ENST00000518721.5, OTTHUMT00000380170
    Conserved Domains (8) summary
    cd07641
    Location:54268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10711127
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:601689
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:316422
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:326411
    PH; PH domain
    pfam01412
    Location:439555
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:582667
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:601634
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p12 Primary Assembly

    Range
    130052104..130443848 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013468.1XP_016868957.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X6

    Conserved Domains (8) summary
    cd11965
    Location:10151071
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:545633
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:260366
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:270355
    PH; PH domain
    pfam01412
    Location:383499
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:526611
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:545578
    ANK; ANK repeat [structural motif]
    cl12013
    Location:1209
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  2. XM_017013469.1XP_016868958.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X7

    Conserved Domains (7) summary
    cd07641
    Location:54268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10141070
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:601689
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:316422
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:601634
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:439555
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:7271003
    Atrophin-1; Atrophin-1 family
  3. XM_006716566.1XP_006716629.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X5

    Conserved Domains (7) summary
    cd07641
    Location:54268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10171073
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:604692
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:319425
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:604637
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:442558
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:7301006
    Atrophin-1; Atrophin-1 family
  4. XM_005250925.1XP_005250982.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9ULH1
    Conserved Domains (7) summary
    cd07641
    Location:54268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10741130
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:604692
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:319425
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:604637
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:442558
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:7271063
    Atrophin-1; Atrophin-1 family
  5. XM_006716564.1XP_006716627.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_006716627.1

    Conserved Domains (8) summary
    cd07641
    Location:47261
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10671123
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:597685
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:312418
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:322407
    PH; PH domain
    pfam01412
    Location:435551
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:578663
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:597630
    ANK; ANK repeat [structural motif]
  6. XM_006716563.3XP_006716626.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_006716626.1

    UniProtKB/Swiss-Prot
    Q9ULH1
    Conserved Domains (7) summary
    cd07641
    Location:54268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10741130
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:604692
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:319425
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:604637
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:442558
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:7271063
    Atrophin-1; Atrophin-1 family
  7. XM_011517052.2XP_011515354.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011515354.1

    UniProtKB/Swiss-Prot
    Q9ULH1
    Conserved Domains (7) summary
    cd07641
    Location:54268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10741130
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:604692
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:319425
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:604637
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:442558
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:7271063
    Atrophin-1; Atrophin-1 family
  8. XM_011517053.1XP_011515355.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2

    See identical proteins and their annotated locations for XP_011515355.1

    Conserved Domains (8) summary
    cd07641
    Location:47261
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10671123
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:597685
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:312418
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:322407
    PH; PH domain
    pfam01412
    Location:435551
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:578663
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:597630
    ANK; ANK repeat [structural motif]
  9. XM_006716565.3XP_006716628.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X4

    Conserved Domains (8) summary
    cd11965
    Location:10181074
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:548636
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:263369
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:273358
    PH; PH domain
    pfam01412
    Location:386502
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:529614
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:548581
    ANK; ANK repeat [structural motif]
    cl12013
    Location:1212
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  10. XM_017013467.2XP_016868956.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3

    Related
    ENSP00000429391.1, OTTHUMP00000227438, ENST00000524124.5
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