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ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 [ Homo sapiens (human) ]

Gene ID: 50807, updated on 4-Jan-2024

Summary

Official Symbol
ASAP1provided by HGNC
Official Full Name
ArfGAP with SH3 domain, ankyrin repeat and PH domain 1provided by HGNC
Primary source
HGNC:HGNC:2720
See related
Ensembl:ENSG00000153317 MIM:605953; AllianceGenome:HGNC:2720
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAP; PAG2; AMAP1; DDEF1; ZG14P; CENTB4
Summary
This gene encodes an ADP-ribosylation factor (ARF) GTPase-activating protein. The GTPase-activating activity is stimulated by phosphatidylinositol 4,5-biphosphate (PIP2), and is greater towards ARF1 and ARF5, and lesser for ARF6. This gene maybe involved in regulation of membrane trafficking and cytoskeleton remodeling. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Ubiquitous expression in bone marrow (RPKM 18.3), spleen (RPKM 15.5) and 24 other tissues See more
Orthologs
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Genomic context

See ASAP1 in Genome Data Viewer
Location:
8q24.21-q24.22
Exon count:
41
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (130052104..130443674, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (131178779..131571038, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (131064350..131455920, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene CYFIP related Rac1 interactor B Neighboring gene uncharacterized LOC124902025 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19542 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19543 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19544 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19545 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:131054337-131055152 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27979 Neighboring gene RNA, U7 small nuclear 181 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr8:131067248-131067450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:131081877-131082759 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27980 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131098365-131098897 Neighboring gene microRNA 5194 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:131110363-131110520 Neighboring gene RNA, U6 small nuclear 1255, pseudogene Neighboring gene ASAP1 intronic transcript 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27981 Neighboring gene small nucleolar RNA SNORA12 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:131216140-131217109 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27982 Neighboring gene uncharacterized LOC124902027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27984 Neighboring gene NANOG hESC enhancer GRCh37_chr8:131323031-131323532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27985 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27986 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19546 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131345596-131346175 Neighboring gene ASAP1 intronic transcript 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131370073-131371035 Neighboring gene uncharacterized LOC124902026 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:131380037-131380536 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131388200-131388776 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:131431296-131431799 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19552 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19553 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19554 Neighboring gene Sharpr-MPRA regulatory region 3250 Neighboring gene uncharacterized LOC105375758 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:131540148-131541347 Neighboring gene NFE2L2 motif-containing MPRA enhancer 239 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27987 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27988 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_101181 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr8:131739458-131740657 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:131759497-131759683 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19555 Neighboring gene uncharacterized LOC105375762 Neighboring gene adenylate cyclase 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • KIAA1249

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cadherin binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-3,4,5-trisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylinositol-4,5-bisphosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables phosphatidylserine binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of dendritic spine development IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of membrane tubulation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein localization to cilium IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of postsynapse organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in dendritic spine IEA
Inferred from Electronic Annotation
more info
 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in podosome IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in trans-Golgi network membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Names
130 kDa phosphatidylinositol 4,5-biphosphate-dependent ARF1 GTPase-activating protein
130 kDa phosphatidylinositol 4,5-bisphosphate-dependent ARF1 GTPase-activating protein
ADP-ribosylation factor-directed GTPase-activating protein 1
ARF GTPase-activating protein 1
DEF-1
PIP2-dependent ARF1 GAP
centaurin, beta 4
development and differentiation-enhancing factor 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030354.1 RefSeqGene

    Range
    4987..396557
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001247996.2NP_001234925.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001234925.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional exon (with an in-frame AUG) in the 5' region compared to variant 1. This results in translation initiation from an alternate start site, and a shorter isoform (2) with a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AB033075, AI494058, AP005856, BC144493, DA319233
    Consensus CDS
    CCDS75788.1
    UniProtKB/TrEMBL
    A0A0A0MRE5, H0YBF7
    Related
    ENSP00000350297.2, ENST00000357668.2
    Conserved Domains (8) summary
    cd07641
    Location:47261
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10641120
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:594682
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:309415
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:319404
    PH; PH domain
    pfam01412
    Location:432548
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:575660
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:594627
    ANK; ANK repeat [structural motif]
  2. NM_001362924.1NP_001349853.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AB033075, AI494058, BC144493, BQ645913, DA315979, DA319233, DA416332
    UniProtKB/TrEMBL
    H0YBF7
    Conserved Domains (7) summary
    cd07641
    Location:54268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10741130
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:604692
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:319425
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:604637
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:442558
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:7271063
    Atrophin-1; Atrophin-1 family
  3. NM_001362925.2NP_001349854.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AB033075, AI494058, AP005856, BC144493, BG748866, DA315979, DA319233, DA416332
    UniProtKB/TrEMBL
    H0YBF7
    Conserved Domains (7) summary
    cd07641
    Location:54268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10171073
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:604692
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:319425
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:604637
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:442558
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:7301006
    Atrophin-1; Atrophin-1 family
  4. NM_001362926.2NP_001349855.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AB033075, AI494058, AP005856, BC144493, BG118567, BG748866, DA315979, DA319233, DA416332
    UniProtKB/TrEMBL
    H0YBF7
    Conserved Domains (7) summary
    cd07641
    Location:54268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10141070
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:601689
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:316422
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:601634
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:439555
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:7271003
    Atrophin-1; Atrophin-1 family
  5. NM_018482.4NP_060952.2  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 1

    See identical proteins and their annotated locations for NP_060952.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes isoform 1.
    Source sequence(s)
    AB033075, AI494058, AP005856, BC137135, DA319233
    Consensus CDS
    CCDS6362.1
    UniProtKB/Swiss-Prot
    B2RNV3, Q9ULH1
    UniProtKB/TrEMBL
    H0YBF7
    Related
    ENSP00000429900.1, ENST00000518721.6
    Conserved Domains (8) summary
    cd07641
    Location:54268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10711127
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:601689
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:316422
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:326411
    PH; PH domain
    pfam01412
    Location:439555
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:582667
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:601634
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    130052104..130443674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047421810.1XP_047277766.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X14

    UniProtKB/TrEMBL
    H0YBF7
  2. XM_047421806.1XP_047277762.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X11

    UniProtKB/TrEMBL
    H0YBF7
  3. XM_017013468.2XP_016868957.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X9

    UniProtKB/TrEMBL
    H0YBF7
    Conserved Domains (8) summary
    cd11965
    Location:10151071
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:545633
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:260366
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:270355
    PH; PH domain
    pfam01412
    Location:383499
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:526611
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:545578
    ANK; ANK repeat [structural motif]
    cl12013
    Location:1209
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  4. XM_047421804.1XP_047277760.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X10

    UniProtKB/TrEMBL
    H0YBF7
  5. XM_047421800.1XP_047277756.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2

    UniProtKB/Swiss-Prot
    B2RNV3, Q9ULH1
    UniProtKB/TrEMBL
    H0YBF7
  6. XM_047421799.1XP_047277755.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    H0YBF7
  7. XM_047421805.1XP_047277761.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X10

    UniProtKB/TrEMBL
    H0YBF7
  8. XM_011517052.3XP_011515354.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

    See identical proteins and their annotated locations for XP_011515354.1

    UniProtKB/TrEMBL
    H0YBF7
    Conserved Domains (7) summary
    cd07641
    Location:54268
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10741130
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:604692
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:319425
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:604637
    ANK; ANK repeat [structural motif]
    pfam01412
    Location:442558
    ArfGap; Putative GTPase activating protein for Arf
    cl26464
    Location:7271063
    Atrophin-1; Atrophin-1 family
  9. XM_047421807.1XP_047277763.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X11

    UniProtKB/TrEMBL
    H0YBF7
  10. XM_047421808.1XP_047277764.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X12

    UniProtKB/TrEMBL
    H0YBF7
  11. XM_047421801.1XP_047277757.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    A0A0A0MRE5, H0YBF7
  12. XM_011517053.2XP_011515355.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3

    See identical proteins and their annotated locations for XP_011515355.1

    UniProtKB/TrEMBL
    H0YBF7
    Conserved Domains (8) summary
    cd07641
    Location:47261
    BAR_ASAP1; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 1
    cd11965
    Location:10671123
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:597685
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:312418
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:322407
    PH; PH domain
    pfam01412
    Location:435551
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:578663
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:597630
    ANK; ANK repeat [structural motif]
  13. XM_006716565.3XP_006716628.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    H0YBF7
    Conserved Domains (8) summary
    cd11965
    Location:10181074
    SH3_ASAP1; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 1
    cd00204
    Location:548636
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:263369
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:273358
    PH; PH domain
    pfam01412
    Location:386502
    ArfGap; Putative GTPase activating protein for Arf
    pfam12796
    Location:529614
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:548581
    ANK; ANK repeat [structural motif]
    cl12013
    Location:1212
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  14. XM_017013467.3XP_016868956.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    H0YBF7
  15. XM_047421809.1XP_047277765.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X13

    UniProtKB/TrEMBL
    H0YBF7
  16. XM_047421802.1XP_047277758.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    H0YBF7
  17. XM_047421803.1XP_047277759.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    H0YBF7
  18. XM_047421811.1XP_047277767.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X15

    UniProtKB/TrEMBL
    H0YBF7
    Related
    ENSP00000429391.1, ENST00000524124.5
  19. XM_047421812.1XP_047277768.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X16

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    131178779..131571038 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054360532.1XP_054216507.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X14

    UniProtKB/TrEMBL
    H0YBF7
  2. XM_054360528.1XP_054216503.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X11

    UniProtKB/TrEMBL
    H0YBF7
  3. XM_054360525.1XP_054216500.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X9

    UniProtKB/TrEMBL
    H0YBF7
  4. XM_054360526.1XP_054216501.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X10

    UniProtKB/TrEMBL
    H0YBF7
  5. XM_054360517.1XP_054216492.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X2

    UniProtKB/TrEMBL
    H0YBF7
  6. XM_054360515.1XP_054216490.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    H0YBF7
  7. XM_054360527.1XP_054216502.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X10

    UniProtKB/TrEMBL
    H0YBF7
  8. XM_054360516.1XP_054216491.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X1

    UniProtKB/TrEMBL
    H0YBF7
  9. XM_054360529.1XP_054216504.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X11

    UniProtKB/TrEMBL
    H0YBF7
  10. XM_054360518.1XP_054216493.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X3

    UniProtKB/TrEMBL
    H0YBF7
  11. XM_054360519.1XP_054216494.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X4

    UniProtKB/TrEMBL
    H0YBF7
  12. XM_054360530.1XP_054216505.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X12

    UniProtKB/TrEMBL
    H0YBF7
  13. XM_054360520.1XP_054216495.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X17

    UniProtKB/TrEMBL
    H0YBF7
  14. XM_054360523.1XP_054216498.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X7

    UniProtKB/TrEMBL
    H0YBF7
  15. XM_054360521.1XP_054216496.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X5

    UniProtKB/TrEMBL
    H0YBF7
  16. XM_054360531.1XP_054216506.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X13

    UniProtKB/TrEMBL
    H0YBF7
  17. XM_054360522.1XP_054216497.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X6

    UniProtKB/TrEMBL
    H0YBF7
  18. XM_054360524.1XP_054216499.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X8

    UniProtKB/TrEMBL
    H0YBF7
  19. XM_054360533.1XP_054216508.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X15

    UniProtKB/TrEMBL
    H0YBF7
  20. XM_054360534.1XP_054216509.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform X16