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Dmrt1 doublesex and mab-3 related transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 50796, updated on 24-Jan-2023

Summary

Official Symbol
Dmrt1provided by MGI
Official Full Name
doublesex and mab-3 related transcription factor 1provided by MGI
Primary source
MGI:MGI:1354733
See related
Ensembl:ENSMUSG00000024837 AllianceGenome:MGI:1354733
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; identical protein binding activity; and transcription cis-regulatory region binding activity. Involved in several processes, including male germ cell proliferation; regulation of nuclear division; and regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including gamete generation; positive regulation of male gonad development; and positive regulation of meiosis I. Located in cytoplasm and nucleus. Is expressed in several structures, including early conceptus; gonad; gonad primordium; and mesonephros. Orthologous to human DMRT1 (doublesex and mab-3 related transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 2.8) See more
Orthologs
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Genomic context

See Dmrt1 in Genome Data Viewer
Location:
19; 19 B
Exon count:
5
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (25482982..25581692)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (25505618..25604328)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26207 Neighboring gene predicted gene 5249 Neighboring gene doublesex and mab-3 related transcription factor 3 Neighboring gene RIKEN cDNA 2610016A17 gene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
acts_upstream_of_or_within Sertoli cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Sertoli cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Sertoli cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within developmental process involved in reproduction IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within germ cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in male germ cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male sex determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in male sex differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of meiotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within oocyte development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of meiosis I IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within regulation of nodal signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in sex differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in female germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
doublesex- and mab-3-related transcription factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015826.5NP_056641.2  doublesex- and mab-3-related transcription factor 1

    See identical proteins and their annotated locations for NP_056641.2

    Status: VALIDATED

    Source sequence(s)
    AC132140
    Consensus CDS
    CCDS29717.1
    UniProtKB/Swiss-Prot
    Q9QZ59, Q9QZA4
    Related
    ENSMUSP00000025755.5, ENSMUST00000025755.11
    Conserved Domains (2) summary
    pfam00751
    Location:70116
    DM; DM DNA binding domain
    pfam12374
    Location:128200
    Dmrt1; Double-sex mab3 related transcription factor 1

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    25482982..25581692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250985.1XP_030106845.1  doublesex- and mab-3-related transcription factor 1 isoform X1

    Related
    ENSMUST00000160814.2
    Conserved Domains (2) summary
    pfam00751
    Location:70116
    DM; DM DNA binding domain
    pfam12374
    Location:128200
    Dmrt1; Double-sex mab3 related transcription factor 1