U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Hs6st1 heparan sulfate 6-O-sulfotransferase 1 [ Mus musculus (house mouse) ]

Gene ID: 50785, updated on 25-Dec-2022

Summary

Official Symbol
Hs6st1provided by MGI
Official Full Name
heparan sulfate 6-O-sulfotransferase 1provided by MGI
Primary source
MGI:MGI:1354958
See related
Ensembl:ENSMUSG00000045216 AllianceGenome:MGI:1354958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6Ost1
Summary
Enables heparan sulfate 6-O-sulfotransferase activity. Acts upstream of or within blood vessel development; heparan sulfate proteoglycan biosynthetic process, enzymatic modification; and lung alveolus development. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 15 with or without anosmia. Orthologous to human HS6ST1 (heparan sulfate 6-O-sulfotransferase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 91.8), kidney adult (RPKM 52.1) and 27 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Hs6st1 in Genome Data Viewer
Location:
1; 1 B
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (36107481..36145527)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (36068400..36106446)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39623 Neighboring gene predicted gene, 39624 Neighboring gene predicted gene, 53548 Neighboring gene predicted gene, 33280 Neighboring gene microRNA 6897 Neighboring gene UDP-glucose glycoprotein glucosyltransferase 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heparan sulfate 6-O-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables heparan sulfate 6-O-sulfotransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
heparan-sulfate 6-O-sulfotransferase 1
Names
HS6ST-1
mHS6ST-1
NP_056633.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015818.2NP_056633.2  heparan-sulfate 6-O-sulfotransferase 1

    See identical proteins and their annotated locations for NP_056633.2

    Status: VALIDATED

    Source sequence(s)
    AI182294, BC052316
    Consensus CDS
    CCDS48237.1
    UniProtKB/Swiss-Prot
    Q3TZT5, Q9QYK5
    UniProtKB/TrEMBL
    A0A6P5PRQ8
    Related
    ENSMUSP00000085499.4, ENSMUST00000088174.4
    Conserved Domains (2) summary
    pfam03567
    Location:85350
    Sulfotransfer_2; Sulfotransferase family
    pfam14878
    Location:328402
    DLD; Death-like domain of SPT6

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    36107481..36145527
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)