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H1f2 H1.2 linker histone, cluster member [ Mus musculus (house mouse) ]

Gene ID: 50708, updated on 8-Jan-2023

Summary

Official Symbol
H1f2provided by MGI
Official Full Name
H1.2 linker histone, cluster memberprovided by MGI
Primary source
MGI:MGI:1931526
See related
Ensembl:ENSMUSG00000036181 AllianceGenome:MGI:1931526
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
H1c; H1-2; H1.2; His1a; H1var1; Hist1h1c; 0610008C09Rik
Summary
Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Feb 2014]
Orthologs
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Genomic context

See H1f2 in Genome Data Viewer
Location:
13; 13 A3.1
Exon count:
1
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (23922790..23923514)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (23738807..23739531)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene homeostatic iron regulator Neighboring gene Hist1h1cR1 erythroid cis-regulatory module Neighboring gene family with sequence similarity 113, member A pseudogene Neighboring gene H2A clustered histone 5, pseudogene Neighboring gene H3 clustered histone 3

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC107646

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables chromatin DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables double-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables nucleosomal DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural constituent of chromatin IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in euchromatin IDA
Inferred from Direct Assay
more info
PubMed 
located_in euchromatin ISO
Inferred from Sequence Orthology
more info
 
part_of nucleosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
histone H1.2
Names
H1 VAR.1
H1 histone family, member 2
histone 1, H1c
histone H1
histone cluster 1, H1c

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015786.3NP_056601.1  histone H1.2

    See identical proteins and their annotated locations for NP_056601.1

    Status: REVIEWED

    Source sequence(s)
    AL590388
    Consensus CDS
    CCDS26361.1
    UniProtKB/Swiss-Prot
    P15864
    UniProtKB/TrEMBL
    Q5SZA3
    Related
    ENSMUSP00000045816.2, ENSMUST00000040914.3
    Conserved Domains (1) summary
    cd00073
    Location:34114
    H15; linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated ...

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    23922790..23923514
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)