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REG3A regenerating family member 3 alpha [ Homo sapiens (human) ]

Gene ID: 5068, updated on 5-Mar-2024

Summary

Official Symbol
REG3Aprovided by HGNC
Official Full Name
regenerating family member 3 alphaprovided by HGNC
Primary source
HGNC:HGNC:8601
See related
Ensembl:ENSG00000172016 MIM:167805; AllianceGenome:HGNC:8601
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; HIP/PAP; REG-III
Summary
This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]
Expression
Biased expression in small intestine (RPKM 2111.4) and duodenum (RPKM 1539.8) See more
Orthologs
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Genomic context

Location:
2p12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (79157006..79159753, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (79157332..79160079, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (79384132..79386879, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene regenerating family member 1 gamma, pseudogene Neighboring gene regenerating family member 1 alpha Neighboring gene uncharacterized LOC105374823 Neighboring gene catenin alpha 2 Neighboring gene NANOG hESC enhancer GRCh37_chr2:79620883-79621450 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_59361 Neighboring gene CTNNA2 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ18565

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding TAS
Traceable Author Statement
more info
PubMed 
enables hormone activity IDA
Inferred from Direct Assay
more info
PubMed 
enables hormone activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables oligosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptidoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in acute-phase response IEA
Inferred from Electronic Annotation
more info
 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules TAS
Traceable Author Statement
more info
PubMed 
involved_in negative regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in negative regulation of inflammatory response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of keratinocyte differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of keratinocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell population proliferation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of detection of glucose ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in positive regulation of keratinocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in response to symbiotic bacterium ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in response to wounding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
regenerating islet-derived protein 3-alpha
Names
PAP homologous protein
REG-3-alpha
hepatocarcinoma-intestine-pancreas
hepatointestinal pancreatic protein
human proislet peptide
pancreatic beta cell growth factor
pancreatitis-associated protein 1
proliferation-inducing protein 34
proliferation-inducing protein 42
reg III-alpha
regenerating islet-derived 3 alpha
regenerating islet-derived protein III-alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029902.1 RefSeqGene

    Range
    5002..7749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002580.3NP_002571.1  regenerating islet-derived protein 3-alpha precursor

    See identical proteins and their annotated locations for NP_002571.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the functional protein. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC036776, BQ777112
    Consensus CDS
    CCDS1965.1
    UniProtKB/Swiss-Prot
    Q06141
    UniProtKB/TrEMBL
    D6W5K0, Q53S56
    Related
    ENSP00000304311.2, ENST00000305165.3
    Conserved Domains (1) summary
    cd03594
    Location:40173
    CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)
  2. NM_138937.3NP_620354.1  regenerating islet-derived protein 3-alpha precursor

    See identical proteins and their annotated locations for NP_620354.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK291973, BC036776
    Consensus CDS
    CCDS1965.1
    UniProtKB/Swiss-Prot
    Q06141
    UniProtKB/TrEMBL
    D6W5K0, Q53S56
    Related
    ENSP00000386630.3, ENST00000409839.7
    Conserved Domains (1) summary
    cd03594
    Location:40173
    CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)
  3. NM_138938.3NP_620355.1  regenerating islet-derived protein 3-alpha precursor

    See identical proteins and their annotated locations for NP_620355.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AY544128, BC036776, DC300833
    Consensus CDS
    CCDS1965.1
    UniProtKB/Swiss-Prot
    Q06141
    UniProtKB/TrEMBL
    D6W5K0, Q53S56
    Related
    ENSP00000377456.1, ENST00000393878.5
    Conserved Domains (1) summary
    cd03594
    Location:40173
    CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    79157006..79159753 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    79157332..79160079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)