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REG3A regenerating family member 3 alpha [ Homo sapiens (human) ]

Gene ID: 5068, updated on 13-Jan-2019

Summary

Official Symbol
REG3Aprovided by HGNC
Official Full Name
regenerating family member 3 alphaprovided by HGNC
Primary source
HGNC:HGNC:8601
See related
Ensembl:ENSG00000172016 MIM:167805
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HIP; PAP; PAP1; REG3; INGAP; PAP-H; PBCGF; HIP/PAP; REG-III
Summary
This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014]
Expression
Biased expression in small intestine (RPKM 2111.4) and duodenum (RPKM 1539.8) See more
Orthologs

Genomic context

See REG3A in Genome Data Viewer
Location:
2p12
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 2 NC_000002.12 (79157006..79159754, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (79384132..79386880, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene regenerating family member 1 alpha Neighboring gene regenerating family member 1 gamma, pseudogene Neighboring gene uncharacterized LOC107985902 Neighboring gene uncharacterized LOC105374823 Neighboring gene uncharacterized LOC101927987

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Antimicrobial peptides, organism-specific biosystem (from REACTOME)
    Antimicrobial peptides, organism-specific biosystemAntimicrobial peptides (AMPs) are small molecular weight proteins with broad spectrum of antimicrobial activity against bacteria, viruses, and fungi (Zasloff M 2002; Radek K & Gallo R 2007). The majo...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ18565

Gene Ontology Provided by GOA

Function Evidence Code Pubs
carbohydrate binding TAS
Traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
oligosaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidoglycan binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acute-phase response IEA
Inferred from Electronic Annotation
more info
 
antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
antimicrobial humoral response TAS
Traceable Author Statement
more info
 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cell wall disruption in other organism IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules TAS
Traceable Author Statement
more info
PubMed 
multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
negative regulation of keratinocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of keratinocyte proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of wound healing ISS
Inferred from Sequence or Structural Similarity
more info
 
response to peptide hormone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
regenerating islet-derived protein 3-alpha
Names
PAP homologous protein
REG-3-alpha
hepatocarcinoma-intestine-pancreas
hepatointestinal pancreatic protein
human proislet peptide
pancreatic beta cell growth factor
pancreatitis-associated protein 1
proliferation-inducing protein 34
proliferation-inducing protein 42
reg III-alpha
regenerating islet-derived 3 alpha
regenerating islet-derived protein III-alpha

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029902.1 RefSeqGene

    Range
    5001..7749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002580.2NP_002571.1  regenerating islet-derived protein 3-alpha precursor

    See identical proteins and their annotated locations for NP_002571.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the functional protein. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    BC036776, BQ777112
    Consensus CDS
    CCDS1965.1
    UniProtKB/Swiss-Prot
    Q06141
    UniProtKB/TrEMBL
    Q53S56
    Related
    ENSP00000304311.2, ENST00000305165.2
    Conserved Domains (1) summary
    cd03594
    Location:40173
    CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)
  2. NM_138937.2NP_620354.1  regenerating islet-derived protein 3-alpha precursor

    See identical proteins and their annotated locations for NP_620354.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AK291973, BC036776, BQ777112
    Consensus CDS
    CCDS1965.1
    UniProtKB/Swiss-Prot
    Q06141
    UniProtKB/TrEMBL
    Q53S56
    Related
    ENSP00000386630.3, ENST00000409839.7
    Conserved Domains (1) summary
    cd03594
    Location:40173
    CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)
  3. NM_138938.2NP_620355.1  regenerating islet-derived protein 3-alpha precursor

    See identical proteins and their annotated locations for NP_620355.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
    Source sequence(s)
    AY544128, BC036776, DC300833
    Consensus CDS
    CCDS1965.1
    UniProtKB/Swiss-Prot
    Q06141
    UniProtKB/TrEMBL
    Q53S56
    Related
    ENSP00000377456.1, ENST00000393878.5
    Conserved Domains (1) summary
    cd03594
    Location:40173
    CLECT_REG-1_like; C-type lectin-like domain (CTLD) of the type found in Human REG-1 (lithostathine), REG-4, and avian eggshell-specific proteins: ansocalcin, structhiocalcin-1(SCA-1), and -2(SCA-2)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p12 Primary Assembly

    Range
    79157006..79159754 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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