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PCA3 prostate cancer associated 3 [ Homo sapiens (human) ]

Gene ID: 50652, updated on 2-Mar-2021

Summary

Official Symbol
PCA3provided by HGNC
Official Full Name
prostate cancer associated 3provided by HGNC
Primary source
HGNC:HGNC:8637
See related
Ensembl:ENSG00000225937 MIM:604845
Gene type
ncRNA
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DD3; PCAT3; NCRNA00019; PRUNE2-AS1
Summary
This gene produces a spliced, long non-coding RNA that is highly overexpressed in most types of prostate cancer cells and is used as a specific biomarker for this type of cancer. This gene is embedded in an intronic region of the prune2 gene on the opposite DNA strand. The transcript regulates prune2 levels through formation of a double-stranded RNA that undergoes adenosine deaminase acting on RNA-dependent adenosine-to-inosine RNA editing. In prostate cancer derived cells, overexpression of PCA induced downregulation of prune2, leading to decreased cell proliferation. Conversely, silencing in prostate cancer cells resulted in increased proliferation. Regulation of this gene appears to be sensitive to androgen-receptor activation, a molecular signature of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2017]
Expression
Restricted expression toward prostate (RPKM 4.9) See more
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Genomic context

See PCA3 in Genome Data Viewer
Location:
9q21.2
Exon count:
4
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (76764436..76787569)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (79379352..79402485)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376093 Neighboring gene peptidylprolyl isomerase A pseudogene 87 Neighboring gene uncharacterized LOC105376095 Neighboring gene prune homolog 2 with BCH domain Neighboring gene LYPLA2 pseudogene 3 Neighboring gene forkhead box B2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Other Names

  • PRUNE2 antisense RNA 1
  • prostate cancer antigen 3 (non-protein coding)
  • prostate cancer associated 3 (non-protein coding)
  • prostate cancer associated transcript 3 (non-protein coding)
  • prostate-specific gene DD3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_015342.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an internal exon compared to variant 1.
    Source sequence(s)
    AF103907, AY894120
    Related
    ENST00000645809.1
  2. NR_132312.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript.
    Source sequence(s)
    AF103907, AY894120
    Related
    ENST00000412654.1
  3. NR_132313.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an internal exon and uses an alternate splice site, which results in a shorter transcript compared to variant 1.
    Source sequence(s)
    AF103907, AY894120, DQ374661

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    76764436..76787569
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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