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CALY calcyon neuron specific vesicular protein [ Homo sapiens (human) ]

Gene ID: 50632, updated on 9-Jun-2025
Official Symbol
CALYprovided by HGNC
Official Full Name
calcyon neuron specific vesicular proteinprovided by HGNC
Primary source
HGNC:HGNC:17938
See related
Ensembl:ENSG00000130643 MIM:604647; AllianceGenome:HGNC:17938
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NSG3; DRD1IP
Summary
The protein encoded by this gene is a type II single transmembrane protein. It is required for maximal stimulated calcium release after stimulation of purinergic or muscarinic but not beta-adrenergic receptors. The encoded protein interacts with D1 dopamine receptor and may interact with other DA receptor subtypes and/or GPCRs. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 10.6), adrenal (RPKM 3.4) and 1 other tissue See more
Orthologs
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See CALY in Genome Data Viewer
Location:
10q26.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (133324072..133336896, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (134278597..134292046, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (135137576..135150400, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene tubulin gamma complex component 2 Neighboring gene uncharacterized LOC124902562 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:135106330-135107529 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4243 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135122506-135123201 Neighboring gene ZNF511-PRAP1 readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135127847-135128348 Neighboring gene zinc finger protein 511 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4245 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4246 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135148655-135149330 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135160243-135160902 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:135160903-135161562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:135161563-135162222 Neighboring gene BANF1 pseudogene 2 Neighboring gene proline rich acidic protein 1

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables clathrin light chain binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables clathrin light chain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables clathrin light chain binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in clathrin coat assembly IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in clathrin coat assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in clathrin coat assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in endosomal transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynaptic neurotransmitter receptor internalization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasmic vesicle membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic endocytic zone IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic endocytic zone IMP
Inferred from Mutant Phenotype
more info
PubMed 
Preferred Names
neuron-specific vesicular protein calcyon
Names
D1 dopamine receptor-interacting protein
calcyon D1 dopamine receptor-interacting protein (CALCYON)
calcyon protein
dopamine receptor D1 interacting protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001321617.2NP_001308546.1  neuron-specific vesicular protein calcyon isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL360181
    Conserved Domains (1) summary
    pfam06387
    Location:3899
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)
  2. NM_015722.4NP_056537.1  neuron-specific vesicular protein calcyon isoform 1

    See identical proteins and their annotated locations for NP_056537.1

    Status: VALIDATED

    Source sequence(s)
    AL360181, BC038978, BI914942, BP392207
    Consensus CDS
    CCDS7678.1
    UniProtKB/Swiss-Prot
    Q5VWX3, Q5VWY5, Q5VWY6, Q9NYX4
    Related
    ENSP00000252939.4, ENST00000252939.9
    Conserved Domains (1) summary
    pfam06387
    Location:1181
    Calcyon; D1 dopamine receptor-interacting protein (calcyon)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    133324072..133336896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    134278597..134292046 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)