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DELEC1 deleted in esophageal cancer 1 [ Homo sapiens (human) ]

Gene ID: 50514, updated on 11-Jun-2021

Summary

Official Symbol
DELEC1provided by HGNC
Official Full Name
deleted in esophageal cancer 1provided by HGNC
Primary source
HGNC:HGNC:23658
See related
Ensembl:ENSG00000173077 MIM:604767
Gene type
ncRNA
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CTS9; DEC1
Summary
The function of this gene is not known. This gene is located in a region commonly deleted in esophageal squamous cell carcinomas. Gene expression is reduced or absent in these carcinomas and thus this is a candidate tumor suppressor gene for esophageal squamous cell carcinomas. [provided by RefSeq, Jul 2008]
Annotation information
Note: DEC1 (Gene ID: 50514) and BHLHE40 (Gene ID: 8553) share the DEC1 symbol/alias in common. DEC1 (differentially expressed in chondrocytes 1) is a widely used alternative name for basic helix-loop-helix family member e40 (BHLHE40), which can be confused with the official symbol for deleted in esophageal cancer 1 (DEC1). [23 May 2018]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See DELEC1 in Genome Data Viewer
Location:
9q33.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (115141818..115402644)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (117904097..118164923)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene tenascin C Neighboring gene uncharacterized LOC101928748 Neighboring gene uncharacterized LOC105376233 Neighboring gene uncharacterized LOC105376232 Neighboring gene VISTA enhancer hs1625 Neighboring gene uncharacterized LOC105376235

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
GeneReviews: Not available
Discovery of six new susceptibility loci and analysis of pleiotropic effects in leprosy.
GeneReviews: Not available
Genome-wide association study of survival in patients with pancreatic adenocarcinoma.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Other Names

  • candidate tumor suppressor 9
  • candidate tumor suppressor CTS9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_163556.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AB022761
    Related
    ENST00000374016.5

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    115141818..115402644
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_027530.1: Suppressed sequence

    Description
    NG_027530.1: This RefSeq was removed because it is now thought that this gene does not encode a protein.
  2. NM_017418.2: Suppressed sequence

    Description
    NM_017418.2: This RefSeq was removed because it is now thought that this gene does not encode a protein.
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